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TNIK and TIAM2
Number of citations of the paper that reports this interaction (PMID
17043677
)
96
Data Source:
BioGRID
(two hybrid)
TNIK
TIAM2
Gene Name
TRAF2 and NCK interacting kinase
T-cell lymphoma invasion and metastasis 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytoskeleton
Apical Plasma Membrane
Recycling Endosome
Extracellular Vesicular Exosome
Cytosol
Membrane
Lamellipodium
Filopodium
Growth Cone
Extracellular Vesicular Exosome
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Small GTPase Regulator Activity
Protein Binding
ATP Binding
Receptor Signaling Protein Activity
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Biological Process
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Cytoskeleton Organization
Activation Of JNKK Activity
Wnt Signaling Pathway
Microvillus Assembly
Actin Cytoskeleton Reorganization
Intracellular Signal Transduction
Protein Autophosphorylation
Regulation Of Dendrite Morphogenesis
Protein Localization To Plasma Membrane
Small GTPase Mediated Signal Transduction
Positive Regulation Of Rho GTPase Activity
Positive Regulation Of Apoptotic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Pathways
Oxidative Stress Induced Senescence
Cellular Senescence
Rho GTPase cycle
PPARA activates gene expression
Signaling by GPCR
GPCR downstream signaling
Signalling by NGF
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Cell death signalling via NRAGE, NRIF and NADE
Signaling by Rho GTPases
NRAGE signals death through JNK
G alpha (12/13) signalling events
p75 NTR receptor-mediated signalling
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Brain imaging in schizophrenia (interaction) (
19023125
)
Coronary heart disease (
21347282
)
Protein-Protein Interactions
38 interactors:
ACTG1
AGTPBP1
AKAP9
ANK2
CLU
CNKSR2
DISC1
DPYSL2
DPYSL3
DST
DYNC1H1
GOLGA4
GSE1
GSN
HARS
MACF1
NCK1
NCOR2
NEDD4
NEFM
PAFAH1B1
PDE4DIP
PPM1E
PPP1R13B
RAP2A
SLC9A1
SMARCE1
SNX6
SOS1
SPTBN1
SRGAP3
SYNE1
TIAM2
TNKS
TRAF2
TRIM2
TUBB2A
WWC1
9 interactors:
ANXA7
DISC1
DNM2
H2AFX
PARD3
SH3GL2
TK1
TNIK
UFD1L
Entrez ID
23043
26230
HPRD ID
18206
05273
Ensembl ID
ENSG00000154310
ENSG00000146426
Uniprot IDs
Q9UKE5
B3KW11
E9PKT1
Q8IVF5
PDB IDs
2X7F
Enriched GO Terms of Interacting Partners
?
Neurogenesis
Nervous System Development
Cellular Component Assembly
Movement Of Cell Or Subcellular Component
Cell Differentiation
Organelle Organization
Generation Of Neurons
Cytoskeleton Organization
Regulation Of Neuron Projection Development
Regulation Of Cellular Component Organization
Locomotion
Regulation Of Cell Projection Organization
System Development
Regulation Of Neuron Differentiation
Anatomical Structure Development
Endomembrane System Organization
Regulation Of Cellular Component Size
Signaling
Multicellular Organismal Development
Signal Transduction
Cell Projection Organization
Cell Communication
Regulation Of Neurogenesis
Cellular Localization
Plasma Membrane Organization
Regulation Of Signal Transduction
Axonogenesis
Developmental Process
Positive Regulation Of Signal Transduction
Axon Guidance
Axon Development
Cellular Response To Stimulus
Cell Morphogenesis Involved In Neuron Differentiation
Neuron Projection Development
Cell Morphogenesis
Protein Localization To Plasma Membrane
Cell Projection Morphogenesis
Membrane Organization
Regulation Of Cell Development
Regulation Of Signaling
Cell Part Morphogenesis
Neuron Projection Morphogenesis
Neuron Differentiation
Golgi To Plasma Membrane Protein Transport
Anatomical Structure Morphogenesis
Establishment Of Protein Localization To Plasma Membrane
Establishment Or Maintenance Of Cell Polarity
Cell Development
Protein Localization To Organelle
Cell Morphogenesis Involved In Differentiation
Membrane Organization
Anatomical Structure Development
Developmental Process
Generation Of Neurons
System Development
Neurogenesis
Multicellular Organismal Development
Regulation Of Neuron Projection Development
Regulation Of Cellular Component Organization
Fetal Process Involved In Parturition
Organelle Localization
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Post-Golgi Vesicle-mediated Transport
Cell Differentiation
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Cell Projection Organization
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Organization
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Nervous System Development
Synaptic Vesicle Transport
Negative Regulation Of Membrane Tubulation
Skeletal Muscle Cell Proliferation
Regulation Of Neuron Differentiation
Cellular Localization
Response To Stimulus
Neuron Projection Morphogenesis
Regulation Of Neurogenesis
Cell Proliferation
Response To Cortisol
Apical Constriction
Thymidine Metabolic Process
Asymmetric Cell Division
Establishment Of Vesicle Localization
Vesicle Localization
Deoxyribonucleoside Monophosphate Biosynthetic Process
Neuron Projection Development
Cell Projection Morphogenesis
Antigen Processing And Presentation Of Peptide Antigen
Regulation Of Cell Development
Cell Part Morphogenesis
Activation Of JNKK Activity
Pyrimidine Nucleoside Salvage
Pyrimidine-containing Compound Salvage
Cellular Component Assembly
Protein Localization
Positive Regulation Of Myelination
Golgi Vesicle Transport
Neuron Development
Wnt Signaling Pathway
Tagcloud
?
a549
attenuation
carboxamide
competition
continuing
crosstalk
docking
efforts
emerging
emt
fak
focal
hinge
ky
methylbenzamido
motility
nck
orchestrated
paxillin
pharmacologic
phenylamino
smad
tgf
thiazole
traf2
transforming
triggers
validate
wnt
Tagcloud (Difference)
?
a549
attenuation
carboxamide
competition
continuing
crosstalk
docking
efforts
emerging
emt
fak
focal
hinge
ky
methylbenzamido
motility
nck
orchestrated
paxillin
pharmacologic
phenylamino
smad
tgf
thiazole
traf2
transforming
triggers
validate
wnt
Tagcloud (Intersection)
?