TNIK and SOS1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		TNIK	SOS1
Gene Name		TRAF2 and NCK interacting kinase	son of sevenless homolog 1 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Vesicular Exosome	Cytosol Plasma Membrane Postsynaptic Density Neuronal Cell Body
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding	DNA Binding Ras Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Rho GTPase Activator Activity Protein Binding SH3 Domain Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Reorganization Intracellular Signal Transduction Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Positive Regulation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Leukocyte Migration Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade FCERI mediated MAPK activation Platelet Aggregation (Plug Formation) Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Regulation of KIT signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins SHC1 events in ERBB4 signaling Signalling to RAS Downstream signal transduction Signaling by Rho GTPases Signaling by FGFR mutants Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Signalling to ERKs Axon guidance IRS-mediated signalling IGF1R signaling cascade Rho GTPase cycle IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling Activation of Rac Downstream signaling of activated FGFR G alpha (12/13) signalling events NCAM signaling for neurite out-growth Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade Cell death signalling via NRAGE, NRIF and NADE SOS-mediated signalling SHC-mediated signalling Integrin alphaIIb beta3 signaling p75 NTR receptor-mediated signalling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins SHC-related events Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling Signal attenuation NRAGE signals death through JNK Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling FCERI mediated Ca+2 mobilization Constitutive Signaling by EGFRvIII Signaling by Robo receptor
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Coronary heart disease ( 21347282)
Protein-Protein Interactions		38 interactors: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DISC1 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SLC9A1 SMARCE1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	52 interactors: ABI1 ABI3 ANXA2 ATP6V1E1 BIN1 CAV1 CD19 CD2AP CRK CRKL CSF1R EGFR EPS8 EPS8L1 EPS8L2 ERBB2 ERBB3 ESR1 FGFR1 FRS2 FYN GAB1 GRAP GRB2 HCK HDLBP HRAS ITSN1 ITSN2 LAT2 LCK MAPK1 MUC1 NCK1 NCK2 PACSIN1 PACSIN3 PIK3R2 PLCG1 PTPN11 PTPN6 RANBP9 RIT2 RRAS SH3BP5 SH3KBP1 SHC1 SNX18 SNX9 SPTAN1 TNIK ZAP70
Entrez ID		23043	6654
HPRD ID		18206	01681
Ensembl ID		ENSG00000154310	ENSG00000115904
Uniprot IDs		Q9UKE5	G5E9C8 Q07889
PDB IDs		2X7F	1AWE 1BKD 1DBH 1NVU 1NVV 1NVW 1NVX 1Q9C 1XD2 1XD4 1XDV 2II0 3KSY
Enriched GO Terms of Interacting Partners?		Neurogenesis Nervous System Development Cellular Component Assembly Movement Of Cell Or Subcellular Component Cell Differentiation Organelle Organization Generation Of Neurons Cytoskeleton Organization Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Locomotion Regulation Of Cell Projection Organization System Development Regulation Of Neuron Differentiation Anatomical Structure Development Endomembrane System Organization Regulation Of Cellular Component Size Signaling Multicellular Organismal Development Signal Transduction Cell Projection Organization Cell Communication Regulation Of Neurogenesis Cellular Localization Plasma Membrane Organization Regulation Of Signal Transduction Axonogenesis Developmental Process Positive Regulation Of Signal Transduction Axon Guidance Axon Development Cellular Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Cell Morphogenesis Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Regulation Of Cell Development Regulation Of Signaling Cell Part Morphogenesis Neuron Projection Morphogenesis Neuron Differentiation Golgi To Plasma Membrane Protein Transport Anatomical Structure Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Cell Polarity Cell Development Protein Localization To Organelle Cell Morphogenesis Involved In Differentiation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Fc Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Response To Fibroblast Growth Factor Innate Immune Response Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Protein Kinase Activity Locomotion Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Response To Growth Factor Immune System Process Regulation Of Signaling Regulation Of Immune System Process Phosphatidylinositol-mediated Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Immune Response Leukocyte Migration Positive Regulation Of Protein Modification Process Endocytosis Positive Regulation Of Protein Kinase Activity Defense Response Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Metabolic Process
Tagcloud ?		a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt	accordingly antisense b9 cascade cascades distal gp130 il independently jak lines mapk mediates mediating mitogen mm myeloma next occur oligonucleotide proliferated proliferative ras regardless sense shc stat1 stat3 triggered
Tagcloud (Difference) ?		a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt	accordingly antisense b9 cascade cascades distal gp130 il independently jak lines mapk mediates mediating mitogen mm myeloma next occur oligonucleotide proliferated proliferative ras regardless sense shc stat1 stat3 triggered
Tagcloud (Intersection) ?