TNIK and GOLGA4

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		TNIK	GOLGA4
Description		TRAF2 and NCK interacting kinase	golgin A4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Golgi Membrane Nucleoplasm Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Small GTPase Binding GTPase Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cytoskeleton Organization Nervous System Development Wnt Signaling Pathway Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Microvillus Assembly	Vesicle-mediated Transport Golgi To Plasma Membrane Protein Transport Positive Regulation Of Axon Extension Golgi Vesicle Transport
Pathways		Oxidative Stress Induced Senescence	Retrograde transport at the Trans-Golgi-Network Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Drugs		Fostamatinib
Diseases
GWAS		Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458)	Autism spectrum disorder or schizophrenia ( 28540026) Pulse pressure ( 30578418) Subjective response to lithium treatment ( 26503763)
Interacting Genes		39 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 STRIP1 STRN4 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	11 interacting genes: APP ARL1 ARL3 CIP2A EIF4ENIF1 MACF1 RAB6A RNF10 SERPINB5 TNIK TRAF3IP1
Entrez ID		23043	2803
HPRD ID		18206	03941
Ensembl ID		ENSG00000154310	ENSG00000144674
Uniprot IDs		Q9UKE5	A0A8V8TPI8 A0A8V8TQI6 A0A9L9PX25 C9J0Y3 H0Y6I0 Q13439 Q49A56
PDB IDs		2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7 7XZQ 7XZR 8WM0 8X88	1R4A 1UPT
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Regulation Of Cellular Component Organization Cytoplasm Positive Regulation Of Cellular Component Organization Cytoskeleton Organelle Organization Retrograde Axonal Transport Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Cytosol Positive Regulation Of Cell Projection Organization Positive Regulation Of Axon Extension Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Structural Constituent Of Cytoskeleton Positive Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Signal Transduction Axon Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonal Transport Regulation Of Cell Communication Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Axonogenesis Negative Regulation Of Hippo Signaling Axo-dendritic Transport Regulation Of Axon Extension Glutamatergic Synapse Regulation Of Protein-containing Complex Assembly Neurofibrillary Tangle Extrinsic Component Of Postsynaptic Density Membrane Cell Cortex Regulation Of Signaling Microtubule Cytoskeleton Organization Protein Localization To Plasma Membrane Potassium Channel Activator Activity Regulation Of Intracellular Signal Transduction Dihydropyrimidinase Activity Golgi To Plasma Membrane Protein Transport Maintenance Of Centrosome Location Cellular Localization Establishment Of Protein Localization Extracellular Exosome Supramolecular Fiber Organization Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Protein Transport Microtubule Protein-macromolecule Adaptor Activity	Endosome To Plasma Membrane Transport Vesicle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Microtubule-based Transport Cellular Localization Trans-Golgi Network Membrane Ciliary Basal Body Intracellular Transport Microtubule-based Movement Protein Localization To Golgi Apparatus Establishment Of Localization In Cell Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Projection Organization Cytoplasm Organelle Organization Protein Transport Microtubule Binding Intraciliary Transport Cyclin D2-CDK6 Complex Peptidyl-cysteine Methylation Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Vesicle-mediated Transport Protein Localization To Organelle Centrosome Golgi Vesicle Transport Golgi To Plasma Membrane Transport Glial Cell Development Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Cell Projection Golgi Apparatus GTPase Activity Establishment Of Protein Localization Phospholipase D Activator Activity Protein Localization To Membrane Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Broken Chromosome Clustering Serine-type Endopeptidase Inhibitor Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Endothelin Production
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