TNIK and DYNC1H1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		TNIK	DYNC1H1
Description		TRAF2 and NCK interacting kinase	dynein cytoplasmic 1 heavy chain 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Extracellular Region Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Filopodium Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding RNA Binding Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Identical Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cytoskeleton Organization Nervous System Development Wnt Signaling Pathway Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Microvillus Assembly	Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly
Pathways		Oxidative Stress Induced Senescence	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs		Fostamatinib
Diseases			Distal hereditary motor neuropathies (dHMN)
GWAS		Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		39 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 STRIP1 STRN4 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	25 interacting genes: BRCA1 BTG3 CEBPA COX20 DISC1 DSCAM DSCR9 DUX4 DYNLL1 EGFR FILNC1 ITSN1 KATNA1 KATNB1 LINC01554 MTNR1B NDEL1 PRKCD RHBDD2 SMAD2 SUMO2 TENT5A TNIK YWHAG YWHAQ
Entrez ID		23043	1778
HPRD ID		18206	02524
Ensembl ID		ENSG00000154310	ENSG00000197102
Uniprot IDs		Q9UKE5	Q14204
PDB IDs		2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7 7XZQ 7XZR 8WM0 8X88	5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A 7Z8F 7Z8G 7Z8H 7Z8I 7Z8J 7Z8K 7Z8L 8DYU 8DYV 8FCY 8FD6 8FDT 8FDU 8PQV 8PQW 8PQY 8PQZ 8PR0 8PR1 8PR2 8PR3 8PTK
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Regulation Of Cellular Component Organization Cytoplasm Positive Regulation Of Cellular Component Organization Cytoskeleton Organelle Organization Retrograde Axonal Transport Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Cytosol Positive Regulation Of Cell Projection Organization Positive Regulation Of Axon Extension Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Structural Constituent Of Cytoskeleton Positive Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Signal Transduction Axon Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonal Transport Regulation Of Cell Communication Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Axonogenesis Negative Regulation Of Hippo Signaling Axo-dendritic Transport Regulation Of Axon Extension Glutamatergic Synapse Regulation Of Protein-containing Complex Assembly Neurofibrillary Tangle Extrinsic Component Of Postsynaptic Density Membrane Cell Cortex Regulation Of Signaling Microtubule Cytoskeleton Organization Protein Localization To Plasma Membrane Potassium Channel Activator Activity Regulation Of Intracellular Signal Transduction Dihydropyrimidinase Activity Golgi To Plasma Membrane Protein Transport Maintenance Of Centrosome Location Cellular Localization Establishment Of Protein Localization Extracellular Exosome Supramolecular Fiber Organization Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Protein Transport Microtubule Protein-macromolecule Adaptor Activity	Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing BRCA1-C Complex Cerebral Cortex Cell Migration Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Telencephalon Cell Migration Signal Transduction Forebrain Cell Migration Microtubule Severing
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