TNIK and SYNE1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		TNIK	SYNE1
Gene Name		TRAF2 and NCK interacting kinase	spectrin repeat containing, nuclear envelope 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Vesicular Exosome	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Golgi Apparatus Cytoskeleton Integral Component Of Membrane Sarcomere Nuclear Membrane LINC Complex Postsynaptic Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding	Actin Binding Protein Binding Lamin Binding Protein Homodimerization Activity Poly(A) RNA Binding Actin Filament Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Reorganization Intracellular Signal Transduction Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Nucleus Organization Golgi Organization Establishment Of Nucleus Localization Muscle Cell Differentiation Cytoskeletal Anchoring At Nuclear Membrane Nuclear Matrix Anchoring At Nuclear Membrane
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Meiotic synapsis
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Coronary heart disease ( 21347282)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 21926972 21738484) Bipolar disorder and major depressive disorder (combined) ( 20351715) Tonometry ( 17903302)
Protein-Protein Interactions		38 interactors: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DISC1 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SLC9A1 SMARCE1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	15 interactors: ACTC1 APC CAPN1 CDC42 CDC5L CEP63 DISC1 DTNBP1 EMD KIAA0368 LMNA MUSK NDEL1 SH3BP5 TNIK
Entrez ID		23043	23345
HPRD ID		18206	09762
Ensembl ID		ENSG00000154310	ENSG00000131018
Uniprot IDs		Q9UKE5	Q8NF91
PDB IDs		2X7F	4DXR
Enriched GO Terms of Interacting Partners?		Neurogenesis Nervous System Development Cellular Component Assembly Movement Of Cell Or Subcellular Component Cell Differentiation Organelle Organization Generation Of Neurons Cytoskeleton Organization Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Locomotion Regulation Of Cell Projection Organization System Development Regulation Of Neuron Differentiation Anatomical Structure Development Endomembrane System Organization Regulation Of Cellular Component Size Signaling Multicellular Organismal Development Signal Transduction Cell Projection Organization Cell Communication Regulation Of Neurogenesis Cellular Localization Plasma Membrane Organization Regulation Of Signal Transduction Axonogenesis Developmental Process Positive Regulation Of Signal Transduction Axon Guidance Axon Development Cellular Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Cell Morphogenesis Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Regulation Of Cell Development Regulation Of Signaling Cell Part Morphogenesis Neuron Projection Morphogenesis Neuron Differentiation Golgi To Plasma Membrane Protein Transport Anatomical Structure Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Cell Polarity Cell Development Protein Localization To Organelle Cell Morphogenesis Involved In Differentiation	Cytoskeleton Organization Endomembrane System Organization Microtubule-based Process Nuclear Envelope Disassembly Organelle Organization Microtubule Cytoskeleton Organization Cell Differentiation Membrane Organization Nuclear Envelope Organization Regulation Of Cell Projection Organization Mitotic Nuclear Envelope Reassembly Wnt Signaling Pathway Cell Cycle Process Regulation Of Synapse Organization Nuclear Envelope Reassembly Regulation Of Synapse Structure Or Activity Canonical Wnt Signaling Pathway Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Phosphorylation Striated Muscle Tissue Development Mitotic Cell Cycle Process Muscle Tissue Development Nucleus Organization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cellular Component Organization Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Cell Cycle Multicellular Organismal Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Establishment Or Maintenance Of Cell Polarity Regulation Of Signaling Cardiac Muscle Tissue Development Generation Of Neurons Muscle Structure Development Mitotic Nuclear Envelope Disassembly System Development Regulation Of Cellular Localization Neurogenesis Cellular Localization
Tagcloud ?		a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt	aimed cdna controls correlation distributed encompasses esr1 follicular genotyped genotyping investigating menstrual menstrually migraine mm mrm pgr plink pmm potentially pure qpcr rs3093664 rs9371601 rstudio snps tnf undertaking variants
Tagcloud (Difference) ?		a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt	aimed cdna controls correlation distributed encompasses esr1 follicular genotyped genotyping investigating menstrual menstrually migraine mm mrm pgr plink pmm potentially pure qpcr rs3093664 rs9371601 rstudio snps tnf undertaking variants
Tagcloud (Intersection) ?