LZTS2 and HSPD1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LZTS2	HSPD1
Gene Name		leucine zipper, putative tumor suppressor 2	heat shock 60kDa protein 1 (chaperonin)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Microtubule Midbody	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Coated Pit Cell Surface Membrane Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Coated Vesicle Secretory Granule Protein Complex Lipopolysaccharide Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Cytokinesis Kidney Development Mitotic Nuclear Division Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Microtubule Severing Nuclear Export Spindle Midzone Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus	B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Viral Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation
Pathways			Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		172 interactors: ABT1 AEN ANKRD11 ANKRD36BP1 AP1M1 ARHGAP32 ARMC7 ARNT2 ATPAF2 BAHD1 BEX2 BMS1P5 BYSL C14orf105 C19orf66 C1orf109 C20orf195 C6orf165 C8orf33 CARD9 CBX8 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CEP57L1 CHCHD3 CLIP4 CNNM3 COPB1 CWF19L2 DCUN1D1 DGCR6 DGCR6L DYRK1A DYRK1B DYRK2 EHHADH EIF3D EIF4E2 FAM103A1 FAM107A FAM124B FAM161A FAM74A4 FANCL FBF1 FEM1C FGF12 FKBP6 FRG1 FRMD6 GCC1 GEM GFI1B GMCL1P1 GNL3L GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HSPD1 IQCE KAT5 KAZN KIAA1683 KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 MAB21L3 MAGEB4 MEMO1 MORF4L1 MORF4L2 MORN3 MOS MTA1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 OTUB2 PAK7 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R18 PQBP1 PRKAB2 PSMA1 QARS RAC1 RAD51D RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3RF2 SLC15A3 SLC25A6 SLU7 SMIM3 SNHG11 SNW1 SNX31 SPATA2 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 TBC1D7 TCEA2 TCHP TEAD4 THAP10 THAP7 TNIP3 TRAF2 TRIM29 TRIM42 TSNAX TTC23 TXNL4A USF2 USP2 UTP14C WDYHV1 WT1-AS YTHDC1 ZBTB25 ZBTB38 ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581	40 interactors: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CLEC7A CLU DHFR ERG FHIT HIST2H2BE HSPE1 ITGA3 ITGB1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LRRK2 LZTS2 MAPK6 NOTCH2NL NR3C1 PLG PPP2R1A PPP2R1B PRKACA PRNP RASA1 RGS20 SAMD3 SIRT3 SUMO4 TLR1 TMCC2 YWHAG
Entrez ID		84445	3329
HPRD ID		14341	00318
Ensembl ID		ENSG00000107816	ENSG00000144381
Uniprot IDs		Q9BRK4	P10809
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Ribonucleoprotein Complex Biogenesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Viral Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Organelle Organization RNA Processing Ribonucleoprotein Complex Assembly Regulation Of Cellular Protein Metabolic Process Cellular Macromolecular Complex Assembly Negative Regulation Of Gene Expression Cellular Response To DNA Damage Stimulus RNA Splicing MRNA Processing Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter MRNA Splicing, Via Spliceosome MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of T Cell Activation Cellular Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process	Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Cell Death Regulation Of Cell Death Death Apoptotic Process Positive Regulation Of Apoptotic Process Programmed Cell Death Developmental Process Response To Organic Substance Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Response To Stimulus Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Signaling Negative Regulation Of Cellular Protein Metabolic Process Cell Communication Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Negative Regulation Of Protein Phosphorylation Regulation Of Proteolysis Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intracellular Signal Transduction Cell Differentiation Cell Cycle Process Negative Regulation Of Phosphorylation Response To Stress Mitotic Cell Cycle Phase Transition Regulation Of Protein Phosphorylation Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Regulation Of Cell Adhesion Positive Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Anatomical Structure Morphogenesis Positive Regulation Of Neuron Death Regulation Of Neuron Death Response To Organic Cyclic Compound
Tagcloud ?		a549 anticancer chemotherapeutic clones credits effectively exposing gltscr2 lats1 making mdr1 nf1 paclitaxel panel predetermined profiling pten regards screen screened shrna shrnas smad4 st14 suppressors tumorigenesis tumorigenic vhl wt1	5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1
Tagcloud (Difference) ?		a549 anticancer chemotherapeutic clones credits effectively exposing gltscr2 lats1 making mdr1 nf1 paclitaxel panel predetermined profiling pten regards screen screened shrna shrnas smad4 st14 suppressors tumorigenesis tumorigenic vhl wt1	5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1
Tagcloud (Intersection) ?