LZTS2 and SHANK3

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		LZTS2	SHANK3
Description		leucine zipper tumor suppressor 2	SH3 and multiple ankyrin repeat domains 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Midbody Vesicle	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Projection Neuron Projection Dendritic Spine Neuron Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding	Actin Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Mitotic Cytokinesis Kidney Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Microtubule Severing Nuclear Export Spindle Midzone Assembly Cell Division Primary Ureteric Bud Growth Ureter Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus	MAPK Cascade Synapse Assembly Learning Memory Associative Learning Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synapse Organization Neuromuscular Process Controlling Balance Cognition Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			Neurexins and neuroligins Neurexins and neuroligins RET signaling
Drugs
Diseases
GWAS		Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Regular attendance at a pub or social club ( 29970889)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Platelet count ( 32888494)
Interacting Genes		220 interacting genes: ABI2 ABT1 AEN AIRIM ANKRD11 ANKRD36BP1 AP1M1 ARMC7 ARNT2 ATOSB ATPAF2 BAHD1 BEX2 BMS1P1 BYSL C8orf33 CABP5 CARD9 CATSPER1 CATSPERT CBX8 CCDC187 CCDC198 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CDKN1A CEP57L1 CFAP206 CHCHD3 CHIC2 CLIP4 CNNM3 COPB1 CWF19L2 DCUN1D1 DGCR6 DGCR6L DLG4 DUSP4 DYRK2 EHHADH EIF3D EIF4E2 EXOSC5 FAM107A FAM124B FAM161A FAM221B FAM50B FAM74A4 FAM90A1 FANCL FEM1C FGF12 FKBP6 FNDC11 FRG1 FRMD6 FXR1 GADD45GIP1 GATA1 GCC1 GEM GFI1B GIPC2 GLIDR GLYCTK GMCL2 GNL3L GPANK1 GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HOXB9 HSPD1 IGFN1 INO80B IQCE IQCN KAT5 KAZN KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 LMO3 MAB21L3 MAGEB4 MAPK1 MEMO1 MID2 MORF4L1 MORF4L2 MORN3 MOS MTA1 MYOZ1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 NTAQ1 OTUB2 PAK5 PATZ1 PHF1 PHF19 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R16A PPP1R18 PQBP1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRR35 PSMA1 QARS1 RAC1 RAD51D RAMAC RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3KBP1 SH3RF2 SHANK3 SHFL SLC15A3 SLC25A6 SLC39A14 SLU7 SMARCB1 SMARCD1 SMIM3 SNHG11 SNW1 SNX31 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 SYT17 TBC1D7 TCEA2 TEAD4 THAP10 THAP7 TLE5 TNIP3 TRAF2 TRIM29 TRIM42 TSC1 TSNAX TSSK2 TSSK3 TTC23 TTLL10 TXNL4A UBASH3A UBASH3B USF2 USP2 UTP14C VEZF1 WT1-AS YTHDC1 ZBTB25 ZBTB38 ZC2HC1C ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF124 ZNF20 ZNF250 ZNF408 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581 ZNF648	152 interacting genes: ABCC2 ABI1 ABI2 ACE2 ACTN2 ADGRL1 AGAP7P ALDOA ANKRD35 APP ARHGAP44 ARPC2 ARPC5L ATN1 BAIAP2 C1QBP CA10 CALCOCO1 CAMK2B CCT3 CEP72 CIBAR1 CLTA CLU CNKSR2 COPS5 COPS6 COQ5 CPAP CRELD1 CRKL CSNK1D CTTN CYP51A1 CYTIP DBNL DCTN2 DDB1 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJA3 DNM2 EFEMP1 EFEMP2 EID1 ELAVL1 ERI3 FAM13A FBXO7 FKBP8 FRS3 FRYL GAPDH GOT1 GPR162 GRB2 GRN HAGH HECW1 HGS HNRNPK HOMER3 ICA1 IGSF9 ITGBL1 ITSN1 JAG2 KHDRBS1 KIAA0232 LINGO1 LRRC73 LTBP3 LTBP4 LZTS2 LZTS3 MAPK1 MBIP MBOAT7 MCRS1 MDH2 MEGF10 MEGF11 MEGF6 MIPOL1 MRM3 MT-CO2 MT-ND6 MYO5B N4BP3 NCK1 NCKIPSD NEFL NGRN NOTCH1 NOTCH2 NOTCH2NLA NOTCH3 NR1D1 NRBF2 PAX6 PFKL PHF12 PHLDB1 PLEKHA4 PPHLN1 PPP1CC PPP1R13L PPP1R9B PPP2R3B PRMT2 QSOX1 RBM5 RPS6KA1 RTN3 RUNDC3A SCYL3 SETD2 SH3GL2 SH3GL3 SHANK1 SHARPIN SIPA1 SLC48A1 SNRPN SORBS2 SORBS3 SPAG5 SPTAN1 SRSF9 STK32C SYNGAP1 SYT5 TCF25 TDRD7 TFIP11 THRAP3 TMEM14C TNIP2 TRAF3 TRIM27 TRIM9 TRIP10 TSG101 TUBA1C UCHL1 USP8 VIM VPS18 WWP1 ZCCHC2
Entrez ID		84445	85358
HPRD ID		14341	18979
Ensembl ID		ENSG00000107816	ENSG00000251322
Uniprot IDs		B4DP66 Q9BRK4	Q9BYB0
PDB IDs			6CPK 7C7I 7C7J
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Nucleoplasm Zinc Ion Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Nuclear Speck RNA Processing RNA Splicing, Via Transesterification Reactions RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II MRNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process DNA Binding Nucleic Acid Metabolic Process Alternative MRNA Splicing, Via Spliceosome MRNA Metabolic Process Transcription Coactivator Activity Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process TSC1-TSC2 Complex Cellular Response To Nutrient Levels	Synapse Glutamatergic Synapse Postsynaptic Density Protein Domain Specific Binding Cytoplasm Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Supramolecular Fiber Organization Organelle Organization Identical Protein Binding Regulation Of Cellular Component Organization Endocytosis Cytoskeleton Regulation Of Signal Transduction Cytoskeleton Organization SH3 Domain Binding Positive Regulation Of Cytoskeleton Organization Cytosol Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Postsynaptic Specialization Neuron Projection Signal Transduction Dendrite Development Endosome Cell Projection Organization Regulation Of Actin Filament Organization Cell Projection Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Notch Signaling Pathway Lamellipodium Modulation Of Chemical Synaptic Transmission Plasma Membrane Bounded Cell Projection Organization Import Into Cell Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Synapse Organization Regulation Of Cytoskeleton Organization Actin Filament Organization Neuron Projection Development Cadherin Binding Modification Of Postsynaptic Structure Regulation Of Cell Projection Organization Postsynaptic Cytoskeleton Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?