NINL and APMAP

		NINL	APMAP
Description		ninein like	adipocyte plasma membrane associated protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule	Cell Surface Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Arylesterase Activity Protein Binding
	Biological Process	Microtubule Anchoring At Centrosome
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Macular thickness ( 30535121) Telomere length ( 30185882) Urate levels ( 31578528)	Blood protein levels ( 30072576)
Interacting Genes		52 interacting genes: AKAP17A APEX2 AURKB CBY2 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 ELOA ERBB2 EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 KRT1 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 PRPF18 PRPF3 RBM41 RCOR3 RGS2 RIBC2 RNF40 SH2D4A SH3BP5L SYT17 TCEANC TNNT1 TSC1 TSPYL4 UTP14A YJU2B ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646	5 interacting genes: FAM209A LOXL3 OGT RASA4 SMAD3
Entrez ID		22981	57136
HPRD ID		11120	09840
Ensembl ID		ENSG00000101004	ENSG00000101474
Uniprot IDs		Q9Y2I6	Q9HDC9
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Pole Nucleus Protein Binding Chromosome, Centromeric Region Positive Regulation Of Mitotic Sister Chromatid Segregation Spindle Pole Regulation Of Metaphase Plate Congression Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone Acetyltransferase Complex Positive Regulation Of Chromosome Segregation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone H4K16 Acetyltransferase Activity Spindle Microtubule Protein Localization To Chromosome Regulation Of Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cytoskeleton Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Negative Regulation Of Cell Cycle Phase Transition Zinc Ion Binding Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation RNA Splicing Centrosome	Chromatin DNA Binding Cellular Response To Carbohydrate Stimulus Negative Regulation Of Lung Blood Pressure Nuclear Inner Membrane Nuclear Mineralocorticoid Receptor Binding Cellular Response To Glucose Stimulus Intracellular Glucose Homeostasis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Sterol Response Element Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Paraxial Mesoderm Morphogenesis Response To Glucose Negative Regulation Of Protein Catabolic Process Response To Monosaccharide Protein O-acetylglucosaminyltransferase Activity Peptidyl-lysine Oxidation Fibronectin Fibril Organization Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Carbohydrate Carbohydrate Homeostasis Glucose Homeostasis Pericardium Development Regulation Of Lung Blood Pressure Mesoderm Morphogenesis Immune System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Protein Oxidation Transdifferentiation SMAD Protein Complex Trophoblast Cell Migration Carbon Catabolite Regulation Of Transcription Negative Regulation Of T-helper 17 Cell Lineage Commitment DEAD/H-box RNA Helicase Binding Heteromeric SMAD Protein Complex Epithelium Development Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of Developmental Process Regulation Of Transcription By Glucose Regulation Of Cell Junction Assembly Positive Regulation Of Extracellular Matrix Assembly Embryonic Foregut Morphogenesis Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress NSL Complex Microtubule Anchoring At Centrosome
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