LZTS2 and USF2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		LZTS2	USF2
Description		leucine zipper tumor suppressor 2	upstream transcription factor 2, c-fos interacting
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Midbody Vesicle	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cytokinesis Kidney Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Microtubule Severing Nuclear Export Spindle Midzone Assembly Cell Division Primary Ureteric Bud Growth Ureter Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus	Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription By RNA Polymerase II Lactation Glucose Mediated Signaling Pathway Late Viral Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lipid Homeostasis Cellular Response To Glucose Stimulus
Pathways			Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Regular attendance at a pub or social club ( 29970889)	Adverse response to drug ( 30420678) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		220 interacting genes: ABI2 ABT1 AEN AIRIM ANKRD11 ANKRD36BP1 AP1M1 ARMC7 ARNT2 ATOSB ATPAF2 BAHD1 BEX2 BMS1P1 BYSL C8orf33 CABP5 CARD9 CATSPER1 CATSPERT CBX8 CCDC187 CCDC198 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CDKN1A CEP57L1 CFAP206 CHCHD3 CHIC2 CLIP4 CNNM3 COPB1 CWF19L2 DCUN1D1 DGCR6 DGCR6L DLG4 DUSP4 DYRK2 EHHADH EIF3D EIF4E2 EXOSC5 FAM107A FAM124B FAM161A FAM221B FAM50B FAM74A4 FAM90A1 FANCL FEM1C FGF12 FKBP6 FNDC11 FRG1 FRMD6 FXR1 GADD45GIP1 GATA1 GCC1 GEM GFI1B GIPC2 GLIDR GLYCTK GMCL2 GNL3L GPANK1 GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HOXB9 HSPD1 IGFN1 INO80B IQCE IQCN KAT5 KAZN KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 LMO3 MAB21L3 MAGEB4 MAPK1 MEMO1 MID2 MORF4L1 MORF4L2 MORN3 MOS MTA1 MYOZ1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 NTAQ1 OTUB2 PAK5 PATZ1 PHF1 PHF19 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R16A PPP1R18 PQBP1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRR35 PSMA1 QARS1 RAC1 RAD51D RAMAC RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3KBP1 SH3RF2 SHANK3 SHFL SLC15A3 SLC25A6 SLC39A14 SLU7 SMARCB1 SMARCD1 SMIM3 SNHG11 SNW1 SNX31 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 SYT17 TBC1D7 TCEA2 TEAD4 THAP10 THAP7 TLE5 TNIP3 TRAF2 TRIM29 TRIM42 TSC1 TSNAX TSSK2 TSSK3 TTC23 TTLL10 TXNL4A UBASH3A UBASH3B USF2 USP2 UTP14C VEZF1 WT1-AS YTHDC1 ZBTB25 ZBTB38 ZC2HC1C ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF124 ZNF20 ZNF250 ZNF408 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581 ZNF648	10 interacting genes: BRCA1 EP300 FOS LZTS2 MAF NFYA PPARGC1A RELA TEAD2 USF1
Entrez ID		84445	7392
HPRD ID		14341	02668
Ensembl ID		ENSG00000107816	ENSG00000105698
Uniprot IDs		B4DP66 Q9BRK4	Q15853
PDB IDs			8IA3
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Nucleoplasm Zinc Ion Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Nuclear Speck RNA Processing RNA Splicing, Via Transesterification Reactions RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II MRNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process DNA Binding Nucleic Acid Metabolic Process Alternative MRNA Splicing, Via Spliceosome MRNA Metabolic Process Transcription Coactivator Activity Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process TSC1-TSC2 Complex Cellular Response To Nutrient Levels	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Response To Nutrient Levels Nucleobase-containing Compound Biosynthetic Process DNA Binding Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-DNA Complex Nucleic Acid Metabolic Process Transcription Coactivator Binding Response To Radiation RNA Metabolic Process Sequence-specific DNA Binding Cellular Response To Oxygen-containing Compound Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleobase-containing Compound Metabolic Process Cellular Response To Tumor Necrosis Factor Response To Light Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Glucose Metabolic Process Double-stranded DNA Binding RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Core Promoter Sequence-specific DNA Binding Response To Nutrient Response To UV DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Muscle Stretch Hexose Metabolic Process Response To Insulin Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production
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