LZTS2 and SMARCD1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		LZTS2	SMARCD1
Name		leucine zipper tumor suppressor 2	SWI/SNF related BAF chromatin remodeling complex subunit D1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Midbody Vesicle	Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Brahma Complex NpBAF Complex NBAF Complex GBAF Complex
	Molecular Function	Protein Binding	Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Molecular Adaptor Activity
	Biological Process	Mitotic Cytokinesis Kidney Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Microtubule Severing Nuclear Export Spindle Midzone Assembly Cell Division Primary Ureteric Bud Growth Ureter Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Cellular Response To Fatty Acid Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		None	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
GWAS		Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551 ) Regular attendance at a pub or social club ( 29970889 )	Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 )
Interacting Genes		220 interacting genes: ABI2 ABT1 AEN AIRIM ANKRD11 ANKRD36BP1 AP1M1 ARMC7 ARNT2 ATOSB ATPAF2 BAHD1 BEX2 BMS1P1 BYSL C8orf33 CABP5 CARD9 CATSPER1 CATSPERT CBX8 CCDC187 CCDC198 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CDKN1A CEP57L1 CFAP206 CHCHD3 CHIC2 CLIP4 CNNM3 COPB1 CWF19L2 DCUN1D1 DGCR6 DGCR6L DLG4 DUSP4 DYRK2 EHHADH EIF3D EIF4E2 EXOSC5 FAM107A FAM124B FAM161A FAM221B FAM50B FAM74A4 FAM90A1 FANCL FEM1C FGF12 FKBP6 FNDC11 FRG1 FRMD6 FXR1 GADD45GIP1 GATA1 GCC1 GEM GFI1B GIPC2 GLIDR GLYCTK GMCL2 GNL3L GPANK1 GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HOXB9 HSPD1 IGFN1 INO80B IQCE IQCN KAT5 KAZN KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 LMO3 MAB21L3 MAGEB4 MAPK1 MEMO1 MID2 MORF4L1 MORF4L2 MORN3 MOS MTA1 MYOZ1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 NTAQ1 OTUB2 PAK5 PATZ1 PHF1 PHF19 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R16A PPP1R18 PQBP1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRR35 PSMA1 QARS1 RAC1 RAD51D RAMAC RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3KBP1 SH3RF2 SHANK3 SHFL SLC15A3 SLC25A6 SLC39A14 SLU7 SMARCB1 SMARCD1 SMIM3 SNHG11 SNW1 SNX31 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 SYT17 TBC1D7 TCEA2 TEAD4 THAP10 THAP7 TLE5 TNIP3 TRAF2 TRIM29 TRIM42 TSC1 TSNAX TSSK2 TSSK3 TTC23 TTLL10 TXNL4A UBASH3A UBASH3B USF2 USP2 UTP14C VEZF1 WT1-AS YTHDC1 ZBTB25 ZBTB38 ZC2HC1C ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF124 ZNF20 ZNF250 ZNF408 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581 ZNF648	156 interacting genes: ABI1 ABI2 ABI3 ACTMAP ADAT2 AIRIM ANKRD23 ANKRD49 ANKS1A ANP32B APOA5 AR ARMC10 ARRDC3 BCAS2 BEND5 BEX3 BLOC1S5 BRWD1 C4BPA CALCOCO2 CCDC102B CCDC197 CCDC33 CCDC85B CDC5L CDR2 CDSN CDX2 CEACAM6 CFTR CHFR CHN2 CLNK COG6 COL1A2 CORO1A CUEDC1 CYSRT1 DCTN2 DISC1 EGFL7 EIF4G1 ESR1 ESS2 FAM136A FAM161A FBXO7 FEZ1 FOS FUS GATA1 GCC1 GIGYF1 GINS3 GOLGA6L9 GPRASP3 GRAMD4 HES6 HNRNPC HOMEZ HOXD3 HSF2BP HSPB1 IGKC IKBIP IKZF3 INSC IQCB1 JUN KATNBL1 KDM1A KEAP1 KIAA0753 KLF1 KMT5B KRT15 KRT16 KRT18 KRT27 KRT31 KRT34 KRT37 KRT38 KRT75 LDB2 LDOC1 LZTS2 MAGEA2 MAGEA2B MAGEA6 MED4 MKRN3 MTNR1B MTUS2 NAB2 NECAB2 NELFA NME1 NONO NR1H4 NR3C1 NUCB2 NUDT16L1 NUTM1 OGT PACSIN3 PAICS PBX4 PCBD1 PGR PICK1 PIH1D1 PKNOX2 PLAGL2 PPM1J PRDX1 PRMT6 PSTPIP1 RIF1 RORB RPS29 SCARA5 SCHIP1 SCNM1 SERTAD3 SHISA6 SMUG1 SNF8 SPSB2 STH STMN3 SYCE1L TCP10L THOC7 TLE5 TNIP2 TP53 TRIM27 TRIM54 TRIM72 USHBP1 USP54 VPS37B WASHC1 YJU2B YWHAG ZC2HC1C ZMAT5 ZMYND12 ZNF417 ZNF438 ZNF511 ZNF629 ZNF655 ZNF69
Entrez ID		84445	6602
HPRD ID		14341	03438
Ensembl ID		ENSG00000107816	ENSG00000066117
Uniprot IDs		B4DP66 Q9BRK4	Q96GM5
PDB IDs		Not available	6LTH 6LTJ 7VDV 7Y8R
GO Terms Enriched among Interactors		Protein Binding Nucleus Nucleoplasm Zinc Ion Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Nuclear Speck RNA Processing RNA Splicing, Via Transesterification Reactions RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II MRNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process DNA Binding Nucleic Acid Metabolic Process Alternative MRNA Splicing, Via Spliceosome MRNA Metabolic Process Transcription Coactivator Activity Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process TSC1-TSC2 Complex Cellular Response To Nutrient Levels	Protein Binding Identical Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Nucleus Intermediate Filament Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Estrogen Response Element Binding Supramolecular Fiber Organization Cytoskeleton Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity DNA-binding Transcription Factor Activity Intermediate Filament Regulation Of Actin Nucleation Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Structural Molecule Activity Actin-based Cell Projection Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of MiRNA Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Steroid Binding SCAR Complex Positive Regulation Of MiRNA Transcription Cornified Envelope Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Protein Kinase C Inhibitor Activity Cytoskeleton Organization