LZTS2 and TBC1D7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		LZTS2	TBC1D7
Description		leucine zipper tumor suppressor 2	TBC1 domain family member 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Midbody Vesicle	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cytoplasmic Vesicle TSC1-TSC2 Complex Ciliary Basal Body
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Small GTPase Binding TSC1-TSC2 Complex Binding
	Biological Process	Mitotic Cytokinesis Kidney Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Microtubule Severing Nuclear Export Spindle Midzone Assembly Cell Division Primary Ureteric Bud Growth Ureter Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus	Cellular Response To Starvation Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of GTPase Activity Response To Growth Factor Activation Of GTPase Activity Negative Regulation Of Cilium Assembly Negative Regulation Of TORC1 Signaling
Pathways			TBC/RABGAPs
Drugs
Diseases
GWAS		Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Regular attendance at a pub or social club ( 29970889)	Migraine ( 23793025) Migraine without aura ( 23793025)
Interacting Genes		220 interacting genes: ABI2 ABT1 AEN AIRIM ANKRD11 ANKRD36BP1 AP1M1 ARMC7 ARNT2 ATOSB ATPAF2 BAHD1 BEX2 BMS1P1 BYSL C8orf33 CABP5 CARD9 CATSPER1 CATSPERT CBX8 CCDC187 CCDC198 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CDKN1A CEP57L1 CFAP206 CHCHD3 CHIC2 CLIP4 CNNM3 COPB1 CWF19L2 DCUN1D1 DGCR6 DGCR6L DLG4 DUSP4 DYRK2 EHHADH EIF3D EIF4E2 EXOSC5 FAM107A FAM124B FAM161A FAM221B FAM50B FAM74A4 FAM90A1 FANCL FEM1C FGF12 FKBP6 FNDC11 FRG1 FRMD6 FXR1 GADD45GIP1 GATA1 GCC1 GEM GFI1B GIPC2 GLIDR GLYCTK GMCL2 GNL3L GPANK1 GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HOXB9 HSPD1 IGFN1 INO80B IQCE IQCN KAT5 KAZN KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 LMO3 MAB21L3 MAGEB4 MAPK1 MEMO1 MID2 MORF4L1 MORF4L2 MORN3 MOS MTA1 MYOZ1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 NTAQ1 OTUB2 PAK5 PATZ1 PHF1 PHF19 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R16A PPP1R18 PQBP1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRR35 PSMA1 QARS1 RAC1 RAD51D RAMAC RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3KBP1 SH3RF2 SHANK3 SHFL SLC15A3 SLC25A6 SLC39A14 SLU7 SMARCB1 SMARCD1 SMIM3 SNHG11 SNW1 SNX31 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 SYT17 TBC1D7 TCEA2 TEAD4 THAP10 THAP7 TLE5 TNIP3 TRAF2 TRIM29 TRIM42 TSC1 TSNAX TSSK2 TSSK3 TTC23 TTLL10 TXNL4A UBASH3A UBASH3B USF2 USP2 UTP14C VEZF1 WT1-AS YTHDC1 ZBTB25 ZBTB38 ZC2HC1C ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF124 ZNF20 ZNF250 ZNF408 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581 ZNF648	30 interacting genes: AKT1 ALOX5 APP BAG4 BLZF1 GABARAPL1 HOOK1 IKBKG INCA1 KEAP1 KRT19 KRT35 LDOC1 LNX2 LZTS1 LZTS2 MAP1LC3A MIPOL1 MMADHC NEDD4 NEDD4L PICK1 RPGRIP1 SH3GLB2 SSNA1 TRAF4 TRIM62 TSC1 XPA YWHAZ
Entrez ID		84445	51256
HPRD ID		14341	18165
Ensembl ID		ENSG00000107816	ENSG00000145979
Uniprot IDs		B4DP66 Q9BRK4	Q9P0N9 U3KPY5
PDB IDs			3QWL 4Z6Y 5EJC 5ULO 7DL2 9CE3
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Nucleoplasm Zinc Ion Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Nuclear Speck RNA Processing RNA Splicing, Via Transesterification Reactions RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II MRNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process DNA Binding Nucleic Acid Metabolic Process Alternative MRNA Splicing, Via Spliceosome MRNA Metabolic Process Transcription Coactivator Activity Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process TSC1-TSC2 Complex Cellular Response To Nutrient Levels	Cytosol Cellular Response To Starvation Identical Protein Binding Ubiquitin Protein Ligase Binding Response To Starvation Regulation Of Autophagy Cellular Response To Nutrient Levels Regulation Of Synapse Organization Cytoplasm Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macroautophagy Negative Regulation Of Protein Localization Protein Domain Specific Binding Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Protein Localization To Nucleus Sodium Channel Inhibitor Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Maternal Placenta Development Cellular Response To Decreased Oxygen Levels Protein Polyubiquitination Regulation Of Protein Localization Cytoskeleton Potassium Channel Inhibitor Activity Cellular Response To Nitrogen Starvation Regulation Of Protein Localization To Nucleus Cellular Response To Oxygen Levels Response To Nutrient Levels Nuclear Envelope Lumen Anoikis TORC1 Signaling Protein Localization To Membrane Regulation Of Dendrite Morphogenesis Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of TORC1 Signaling Cellular Response To Stress Regulation Of Sodium Ion Transport Vacuole Organization Negative Regulation Of Sodium Ion Transport Phosphatidylethanolamine Binding Positive Regulation Of Catabolic Process Response To Stress Positive Regulation Of Fibroblast Migration Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis TOR Signaling Regulation Of Protein Catabolic Process Cell Projection Organization
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