LZTS2 and CDKL3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		LZTS2	CDKL3
Description		leucine zipper tumor suppressor 2	cyclin dependent kinase like 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Midbody Vesicle	Nucleus Cytoplasm
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Mitotic Cytokinesis Kidney Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Microtubule Severing Nuclear Export Spindle Midzone Assembly Cell Division Primary Ureteric Bud Growth Ureter Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus	Negative Regulation Of Axon Extension Protein Modification Process Positive Regulation Of Dendrite Morphogenesis Regulation Of Cell Cycle Dendrite Extension
Pathways
Drugs
Diseases
GWAS		Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Regular attendance at a pub or social club ( 29970889)	Eosinophil count ( 27863252) Moderate-to-late spontaneous preterm birth ( 31194736)
Interacting Genes		220 interacting genes: ABI2 ABT1 AEN AIRIM ANKRD11 ANKRD36BP1 AP1M1 ARMC7 ARNT2 ATOSB ATPAF2 BAHD1 BEX2 BMS1P1 BYSL C8orf33 CABP5 CARD9 CATSPER1 CATSPERT CBX8 CCDC187 CCDC198 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CDKN1A CEP57L1 CFAP206 CHCHD3 CHIC2 CLIP4 CNNM3 COPB1 CWF19L2 DCUN1D1 DGCR6 DGCR6L DLG4 DUSP4 DYRK2 EHHADH EIF3D EIF4E2 EXOSC5 FAM107A FAM124B FAM161A FAM221B FAM50B FAM74A4 FAM90A1 FANCL FEM1C FGF12 FKBP6 FNDC11 FRG1 FRMD6 FXR1 GADD45GIP1 GATA1 GCC1 GEM GFI1B GIPC2 GLIDR GLYCTK GMCL2 GNL3L GPANK1 GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HOXB9 HSPD1 IGFN1 INO80B IQCE IQCN KAT5 KAZN KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 LMO3 MAB21L3 MAGEB4 MAPK1 MEMO1 MID2 MORF4L1 MORF4L2 MORN3 MOS MTA1 MYOZ1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 NTAQ1 OTUB2 PAK5 PATZ1 PHF1 PHF19 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R16A PPP1R18 PQBP1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRR35 PSMA1 QARS1 RAC1 RAD51D RAMAC RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3KBP1 SH3RF2 SHANK3 SHFL SLC15A3 SLC25A6 SLC39A14 SLU7 SMARCB1 SMARCD1 SMIM3 SNHG11 SNW1 SNX31 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 SYT17 TBC1D7 TCEA2 TEAD4 THAP10 THAP7 TLE5 TNIP3 TRAF2 TRIM29 TRIM42 TSC1 TSNAX TSSK2 TSSK3 TTC23 TTLL10 TXNL4A UBASH3A UBASH3B USF2 USP2 UTP14C VEZF1 WT1-AS YTHDC1 ZBTB25 ZBTB38 ZC2HC1C ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF124 ZNF20 ZNF250 ZNF408 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581 ZNF648	31 interacting genes: APP ATG4A CYSRT1 DISC1 DNAAF6 FXR1 FXR2 GGA1 GOLGA2 IKZF1 KANK2 KASH5 KRTAP10-9 LRP2BP LRRK2 LZTS2 MCC MDFI MTUS2 PICK1 PIH1D2 RABEP1 SNRNP70 SRPK1 TRIM27 TRIM37 TTF2 ZBTB14 ZBTB43 ZBTB8A ZRANB1
Entrez ID		84445	51265
HPRD ID		14341	09766
Ensembl ID		ENSG00000107816	ENSG00000006837
Uniprot IDs		B4DP66 Q9BRK4	B4DX41 Q8IVW4
PDB IDs			3ZDU
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Nucleoplasm Zinc Ion Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Nuclear Speck RNA Processing RNA Splicing, Via Transesterification Reactions RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II MRNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process DNA Binding Nucleic Acid Metabolic Process Alternative MRNA Splicing, Via Spliceosome MRNA Metabolic Process Transcription Coactivator Activity Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process TSC1-TSC2 Complex Cellular Response To Nutrient Levels	Regulation Of Wnt Signaling Pathway Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Autophagy Positive Regulation Of Catabolic Process Protein Localization To Ciliary Membrane Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Wnt Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Cellular Component Assembly Negative Regulation Of Long-term Synaptic Potentiation Identical Protein Binding Negative Regulation Of Wnt Signaling Pathway Modulation Of Chemical Synaptic Transmission Protein Homodimerization Activity Cellular Localization Response To Manganese Ion Neuron Projection Regulation Of Receptor Internalization Cytoplasm Regulation Of Synaptic Transmission, Glutamatergic Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Translation Regulator Activity Regulation Of Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Response To Catecholamine Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Postsynapse Presynapse Regulation Of Primary Metabolic Process Dentate Gyrus Development Regulation Of Canonical Wnt Signaling Pathway Intracellular Transport Positive Regulation Of Receptor Internalization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Macromolecule Metabolic Process Organelle Assembly Aggresome
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