FHL1 and CHEK2

Number of citations of the paper that reports this interaction (PubMedID 28094252)
51

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology, unspecified method)

		FHL1	CHEK2
Description		four and a half LIM domains 1	checkpoint kinase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus PML Body
	Molecular Function	Protein Binding Zinc Ion Binding Transmembrane Transporter Binding Metal Ion Binding Channel Activator Activity Potassium Channel Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Autophagosome Assembly DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle DNA Repair Double-strand Break Repair Regulation Of DNA-templated Transcription Protein Phosphorylation Apoptotic Process DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Stress Regulation Of Protein Catabolic Process Response To Starvation Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Protein Stabilization Cell Division Thymocyte Apoptotic Process Protein K63-linked Ubiquitination Cellular Response To Xenobiotic Stimulus Cellular Response To Gamma Radiation Mitotic Spindle Assembly Replicative Senescence Regulation Of Signal Transduction By P53 Class Mediator Response To Glycoside Cellular Response To Bisphenol A Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Anoikis Regulation Of Autophagosome Assembly Positive Regulation Of Autophagosome Assembly
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs			XL844 Enzastaurin Fostamatinib
Diseases		X-linked myopathy with postural muscle atrophy (XMPMA) Scapuloperoneal myopathy (SPM) Reducing body myopathy (RBM) Emery-Dreifuss muscular dystrophy	Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
GWAS			Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874) Breast cancer ( 23535729 29059683) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Essential hypertension (time to event) ( 32589924) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Immature fraction of reticulocytes ( 32888494) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung cancer ( 24880342) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Menopause (age at onset) ( 26414677) Myeloproliferative neoplasms ( 33057200) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Optic disc size ( 31809533) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29117387) Red cell distribution width ( 28957414 32888494) Smoking initiation ( 33082346) Vertical cup-disc ratio ( 25241763 20548946 31798171 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		30 interacting genes: APP CBX4 CHEK2 CLMN CSRP3 DBN1 DEAF1 DOCK9 EED ENO1 FHL2 HES1 HIVEP3 IGFBP5 LAMA4 MACF1 MYBPC1 NFIL3 PAX7 PDE4DIP PDLIM3 RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE ZBTB40	85 interacting genes: AATF APP ARHGAP1 ASF1A ATM ATR BAALC BEX1 BRCA1 BRCA2 CALM1 CCL5 CDC25A CDC25C CDH13 CDK11B CDKN1A CYP17A1 DAPK3 DBF4 DIRAS3 E2F1 ELAVL1 ENO1 ERCC6 FHL1 FHL3 FOXM1 GNAS HMGN1 HOXC6 ITIH5 KLK7 KLK9 KPNA2 LATS2 LYPD3 MAPT MDC1 MDM2 MDM4 MED1 MRC1 MSH2 MUS81 NBN NR4A1 NSD3 PLK1 PLK3 PML POLR2L PPM1D PPP1R12A PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM14 PRKDC PRMT2 PSMC3IP PSME3 RAD9A RCHY1 REV3L RHOBTB2 RNF8 SIAH2 SLC25A6 SRPK1 SRPK2 ST14 STMN1 STRAP TLR3 TP53 TSSK1B USP39 VHL XRCC1
Entrez ID		2273	11200
HPRD ID		02157	05084
Ensembl ID		ENSG00000022267	ENSG00000183765
Uniprot IDs		B7Z9A1 Q13642 Q5JXI2	A0A7P0MUT5 O96017
PDB IDs		1X63 2CUP 2CUR 2EGQ	1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Sarcomere Organization Structural Constituent Of Muscle Negative Regulation Of RNA Metabolic Process Cardiac Myofibril Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus M Band Aorta Morphogenesis Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Supramolecular Fiber Organization Myofibril Assembly Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Actin Binding Actomyosin Structure Organization Negative Regulation Of Biosynthetic Process Sex Chromatin Detection Of Muscle Stretch Telethonin Binding Cell Differentiation Negative Regulation Of Metabolic Process Transcription Corepressor Binding Z Disc Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Negative Regulation Of Macromolecule Metabolic Process Artery Morphogenesis Cadherin Binding Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Cytoskeleton Organization Heart Trabecula Formation Regulation Of Development, Heterochronic Actinin Binding Muscle Tissue Morphogenesis Muscle Alpha-actinin Binding	Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Cycle Process Nucleoplasm Protein Phosphatase Type 2A Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Nucleus Regulation Of Primary Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Response To Ionizing Radiation Double-strand Break Repair DNA Repair Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process DNA Metabolic Process Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway Response To Gamma Radiation Regulation Of DNA Metabolic Process Response To Radiation Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Signal Transduction Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Chromatin Organization Regulation Of DNA Repair G2/M Transition Of Mitotic Cell Cycle Protein Phosphatase Activator Activity Regulation Of Double-strand Break Repair DNA Recombination Mitotic Cell Cycle Phase Transition
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