FHL1 and ZBTB40

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		FHL1	ZBTB40
Description		four and a half LIM domains 1	zinc finger and BTB domain containing 40
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Nucleus
	Molecular Function	Protein Binding Zinc Ion Binding Transmembrane Transporter Binding Metal Ion Binding Channel Activator Activity Potassium Channel Activator Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Transcription By RNA Polymerase II DNA Damage Response Bone Mineralization
Pathways
Drugs
Diseases		X-linked myopathy with postural muscle atrophy (XMPMA) Scapuloperoneal myopathy (SPM) Reducing body myopathy (RBM) Emery-Dreifuss muscular dystrophy
GWAS			Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Birth weight ( 27680694) Bone mineral density ( 21533022 24249740) Bone mineral density (hip) ( 19801982 18445777) Bone mineral density (spine) ( 18445777 19801982) Bone mineral density (total hip) ( 29883787) Dupuytren's disease ( 28886342) Endometriosis ( 23472165) Femoral neck bone mineral density ( 22504420 29499414) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Triglyceride levels ( 34074324)
Interacting Genes		30 interacting genes: APP CBX4 CHEK2 CLMN CSRP3 DBN1 DEAF1 DOCK9 EED ENO1 FHL2 HES1 HIVEP3 IGFBP5 LAMA4 MACF1 MYBPC1 NFIL3 PAX7 PDE4DIP PDLIM3 RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE ZBTB40	1 interacting genes: FHL1
Entrez ID		2273	9923
HPRD ID		02157	11086
Ensembl ID		ENSG00000022267	ENSG00000184677
Uniprot IDs		B7Z9A1 Q13642 Q5JXI2	B3KR52 F8WAI8 Q1RMZ5 Q9NUA8
PDB IDs		1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Sarcomere Organization Structural Constituent Of Muscle Negative Regulation Of RNA Metabolic Process Cardiac Myofibril Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus M Band Aorta Morphogenesis Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Supramolecular Fiber Organization Myofibril Assembly Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Actin Binding Actomyosin Structure Organization Negative Regulation Of Biosynthetic Process Sex Chromatin Detection Of Muscle Stretch Telethonin Binding Cell Differentiation Negative Regulation Of Metabolic Process Transcription Corepressor Binding Z Disc Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Negative Regulation Of Macromolecule Metabolic Process Artery Morphogenesis Cadherin Binding Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Cytoskeleton Organization Heart Trabecula Formation Regulation Of Development, Heterochronic Actinin Binding Muscle Tissue Morphogenesis Muscle Alpha-actinin Binding	Channel Activator Activity Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Channel Activator Activity Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Membrane Depolarization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Potassium Ion Transport Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Potassium Ion Transport Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Muscle Organ Development Transmembrane Transporter Binding Negative Regulation Of Cell Growth Muscle Structure Development Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cation Transmembrane Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Growth Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Cell Cycle Process Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metal Ion Transport Regulation Of Cell Cycle Phase Transition Regulation Of Cell Growth Regulation Of Monoatomic Ion Transport Focal Adhesion Regulation Of Membrane Potential
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?