FHL1 and MYBPC1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		FHL1	MYBPC1
Description		four and a half LIM domains 1	myosin binding protein C1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Cytosol Myofibril M Band Myosin Filament
	Molecular Function	Protein Binding Zinc Ion Binding Transmembrane Transporter Binding Metal Ion Binding Channel Activator Activity Potassium Channel Activator Activity	Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding
	Biological Process	Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Cell Adhesion Sarcomere Organization
Pathways			Striated Muscle Contraction
Drugs
Diseases		X-linked myopathy with postural muscle atrophy (XMPMA) Scapuloperoneal myopathy (SPM) Reducing body myopathy (RBM) Emery-Dreifuss muscular dystrophy
GWAS			Lung function (FEV1) ( 24023788) Memory decline ( 31985465)
Interacting Genes		30 interacting genes: APP CBX4 CHEK2 CLMN CSRP3 DBN1 DEAF1 DOCK9 EED ENO1 FHL2 HES1 HIVEP3 IGFBP5 LAMA4 MACF1 MYBPC1 NFIL3 PAX7 PDE4DIP PDLIM3 RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE ZBTB40	27 interacting genes: ACO1 AMOT ANKRD1 ASH2L C1QTNF9 CALM1 CAPN3 CLIP4 DNAJB5 DNAJB6 DYSF FHL1 FHL2 FHL3 GABARAP GABARAPL1 GABARAPL2 KLHL41 MAP1LC3A MEOX2 MYBPC2 NCF1 RAF1 SGCG TRIM55 TRIM63 TTN
Entrez ID		2273	4604
HPRD ID		02157	01185
Ensembl ID		ENSG00000022267	ENSG00000196091
Uniprot IDs		B7Z9A1 Q13642 Q5JXI2	A8KAB1 B3KPP3 Q00872
PDB IDs		1X63 2CUP 2CUR 2EGQ	1X44 2DAV 2YUV 2YUW 2YUX 2YUZ 2YXM
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Sarcomere Organization Structural Constituent Of Muscle Negative Regulation Of RNA Metabolic Process Cardiac Myofibril Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus M Band Aorta Morphogenesis Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Supramolecular Fiber Organization Myofibril Assembly Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Actin Binding Actomyosin Structure Organization Negative Regulation Of Biosynthetic Process Sex Chromatin Detection Of Muscle Stretch Telethonin Binding Cell Differentiation Negative Regulation Of Metabolic Process Transcription Corepressor Binding Z Disc Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Negative Regulation Of Macromolecule Metabolic Process Artery Morphogenesis Cadherin Binding Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Cytoskeleton Organization Heart Trabecula Formation Regulation Of Development, Heterochronic Actinin Binding Muscle Tissue Morphogenesis Muscle Alpha-actinin Binding	Cellular Response To Nitrogen Starvation Titin Binding Phosphatidylethanolamine Binding Actin Cytoskeleton Organization Z Disc M Band Cytoskeleton Organization Actin Filament-based Process Sarcomere Organization Actomyosin Structure Organization Autophagosome Maturation Phospholipid Binding Autophagosome Membrane Mitophagy GABA Receptor Binding Autophagy Of Mitochondrion Organelle Organization Autophagosome Response To Muscle Stretch Myofibril Assembly Autophagosome Assembly Autophagosome Organization Adenylate Cyclase Activator Activity Beta-tubulin Binding Structural Constituent Of Muscle Muscle Organ Development Response To Iron(II) Ion Muscle Structure Development Protein-containing Complex Disassembly Organelle Assembly Cytoplasm Macroautophagy Response To Metal Ion Vacuole Organization Microtubule Cellular Response To Starvation Pseudopodium Response To Starvation Cellular Response To Nutrient Levels Cytosol I Band Supramolecular Fiber Organization Response To Iron Ion Autophagy Response To Calcium Ion Ubiquitin Protein Ligase Binding Anatomical Structure Formation Involved In Morphogenesis Protein Binding Calcium-dependent Self Proteolysis Monocyte Activation Involved In Immune Response
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