FHL1 and CBX4

Number of citations of the paper that reports this interaction (PubMedID 15710417)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		FHL1	CBX4
Description		four and a half LIM domains 1	chromobox 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transmembrane Transporter Binding Metal Ion Binding Channel Activator Activity Potassium Channel Activator Activity	Transcription Cis-regulatory Region Binding Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding Transferase Activity SUMO Transferase Activity Enzyme Binding SUMO Binding Phosphoprotein Binding SUMO Ligase Activity
	Biological Process	Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases		X-linked myopathy with postural muscle atrophy (XMPMA) Scapuloperoneal myopathy (SPM) Reducing body myopathy (RBM) Emery-Dreifuss muscular dystrophy
GWAS			Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)
Interacting Genes		30 interacting genes: APP CBX4 CHEK2 CLMN CSRP3 DBN1 DEAF1 DOCK9 EED ENO1 FHL2 HES1 HIVEP3 IGFBP5 LAMA4 MACF1 MYBPC1 NFIL3 PAX7 PDE4DIP PDLIM3 RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE ZBTB40	28 interacting genes: ARID3C CBS CHD3 CREBBP CTBP1 CTBP2 FHL1 H3-3A H3-4 H3C1 H3C14 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP STIP1 SUV39H1 TRIM21 UBE2I ZBED1 ZEB2
Entrez ID		2273	8535
HPRD ID		02157	04357
Ensembl ID		ENSG00000022267	ENSG00000141582
Uniprot IDs		B7Z9A1 Q13642 Q5JXI2	A0A0S2Z5B2 O00257
PDB IDs		1X63 2CUP 2CUR 2EGQ	2K28 3I8Z 5EPL
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Sarcomere Organization Structural Constituent Of Muscle Negative Regulation Of RNA Metabolic Process Cardiac Myofibril Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus M Band Aorta Morphogenesis Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Supramolecular Fiber Organization Myofibril Assembly Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Actin Binding Actomyosin Structure Organization Negative Regulation Of Biosynthetic Process Sex Chromatin Detection Of Muscle Stretch Telethonin Binding Cell Differentiation Negative Regulation Of Metabolic Process Transcription Corepressor Binding Z Disc Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Negative Regulation Of Macromolecule Metabolic Process Artery Morphogenesis Cadherin Binding Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Cytoskeleton Organization Heart Trabecula Formation Regulation Of Development, Heterochronic Actinin Binding Muscle Tissue Morphogenesis Muscle Alpha-actinin Binding	Chromatin Remodeling Nucleus Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II PML Body Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process RING-like Zinc Finger Domain Binding DNA Binding Chromosome Structural Constituent Of Chromatin Protein-DNA Complex Assembly Zinc Ion Binding Nucleosome Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Centromere Complex Assembly Nucleosome Transcription Coregulator Binding Identical Protein Binding Sex Chromatin Nucleosome Organization Positive Regulation Of RNA Metabolic Process Heterochromatin Formation Heterochromatin Transcription Coactivator Activity Unmethylated CpG Binding Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Chromatin
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