FHL1 and RING1

Number of citations of the paper that reports this interaction (PMID 14999091)
6

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (in vivo)

		FHL1	RING1
Gene Name		four and a half LIM domains 1	ring finger protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Sex Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Molecular_function Protein Binding Zinc Ion Binding Ion Channel Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Regulation Of Membrane Depolarization Muscle Organ Development Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Transcription, DNA-templated Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		19 interactors: AKAP12 CBX4 DBN1 DEAF1 EED FHL2 HES1 HIVEP3 MYBPC1 PDE4DIP PRNP RBPJ RING1 SRF SRPK1 TTN TXNIP UBE2E2 USP15	31 interactors: APP BMI1 CBX4 CBX6 CBX7 CBX8 E2F6 ELAC2 FBXO38 FHL1 HIST3H3 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PHC1 PIK3R3 RB1 RNF2 RYBP UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K USP7 YAF2
Entrez ID		2273	6015
HPRD ID		02157	03624
Ensembl ID		ENSG00000022267	ENSG00000204227
Uniprot IDs		B7Z9A1 Q13642	Q06587
PDB IDs		1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?		Cardiocyte Differentiation Heart Morphogenesis Aorta Morphogenesis Negative Regulation Of Transcription, DNA-templated Heart Trabecula Morphogenesis Aorta Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Muscle Structure Development Transcription, DNA-templated Regulation Of RNA Metabolic Process Striated Muscle Tissue Development Negative Regulation Of Gene Expression RNA Biosynthetic Process Muscle Cell Differentiation Cardiac Chamber Development Negative Regulation Of Biosynthetic Process Muscle Tissue Development Trabecula Morphogenesis RNA Metabolic Process Auditory Receptor Cell Fate Commitment Dorsal Aorta Morphogenesis Regulation Of Gene Expression Muscle Cell Development Artery Morphogenesis Dorsal Aorta Development Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Muscle Tissue Development Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription, DNA-templated Artery Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cardiac Muscle Cell Development Tissue Development Regulation Of Metabolic Process Cardiac Muscle Cell Myoblast Differentiation Nucleobase-containing Compound Metabolic Process Cell Development Heart Development Regulation Of Transcription From RNA Polymerase II Promoter Cardioblast Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Heart Trabecula Formation Cellular Nitrogen Compound Metabolic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Histone Ubiquitination Chromatin Modification Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Negative Regulation Of Gene Expression Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process RNA Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Protein Monoubiquitination Nucleobase-containing Compound Metabolic Process Cellular Protein Modification Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone Monoubiquitination Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein K11-linked Ubiquitination Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Histone H2A Monoubiquitination Regulation Of Cell Cycle Phase Transition Cellular Protein Metabolic Process Regulation Of Metabolic Process Histone H2A Ubiquitination Organelle Organization Metabolic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		764g atrophy biopsy bodies boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness	4h accomplish antioxidant ck cmv cortex creatine de dehydrogenase downregulated e3 electrophoresis extremely finger hselm lactate ldh ligase nontg secretase sel selenium selenoprotein selm spots synaptotagmin sytxv tg upregulated
Tagcloud (Difference) ?		764g atrophy biopsy bodies boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness	4h accomplish antioxidant ck cmv cortex creatine de dehydrogenase downregulated e3 electrophoresis extremely finger hselm lactate ldh ligase nontg secretase sel selenium selenoprotein selm spots synaptotagmin sytxv tg upregulated
Tagcloud (Intersection) ?