FHL1 and PDLIM3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		FHL1	PDLIM3
Description		four and a half LIM domains 1	PDZ and LIM domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Stress Fiber Cytoplasm Cytosol Adherens Junction Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Protein Binding Zinc Ion Binding Transmembrane Transporter Binding Metal Ion Binding Channel Activator Activity Potassium Channel Activator Activity	Actin Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Actin Filament Organization Heart Development Actin Cytoskeleton Organization Muscle Structure Development
Pathways
Drugs
Diseases		X-linked myopathy with postural muscle atrophy (XMPMA) Scapuloperoneal myopathy (SPM) Reducing body myopathy (RBM) Emery-Dreifuss muscular dystrophy
GWAS
Interacting Genes		30 interacting genes: APP CBX4 CHEK2 CLMN CSRP3 DBN1 DEAF1 DOCK9 EED ENO1 FHL2 HES1 HIVEP3 IGFBP5 LAMA4 MACF1 MYBPC1 NFIL3 PAX7 PDE4DIP PDLIM3 RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE ZBTB40	11 interacting genes: ABCA1 ACTN2 FHL1 MYOT MYOZ2 MYOZ3 MYPN PALLD RANBP2 RHOU RYR1
Entrez ID		2273	27295
HPRD ID		02157	08388
Ensembl ID		ENSG00000022267	ENSG00000154553
Uniprot IDs		B7Z9A1 Q13642 Q5JXI2	A0A087WYF8 A0A2U3TZH4 Q53GG5
PDB IDs		1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Sarcomere Organization Structural Constituent Of Muscle Negative Regulation Of RNA Metabolic Process Cardiac Myofibril Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus M Band Aorta Morphogenesis Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Supramolecular Fiber Organization Myofibril Assembly Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Actin Binding Actomyosin Structure Organization Negative Regulation Of Biosynthetic Process Sex Chromatin Detection Of Muscle Stretch Telethonin Binding Cell Differentiation Negative Regulation Of Metabolic Process Transcription Corepressor Binding Z Disc Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Negative Regulation Of Macromolecule Metabolic Process Artery Morphogenesis Cadherin Binding Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Cytoskeleton Organization Heart Trabecula Formation Regulation Of Development, Heterochronic Actinin Binding Muscle Tissue Morphogenesis Muscle Alpha-actinin Binding	Z Disc FATZ Binding Actin Binding Actin Cytoskeleton Actin Cytoskeleton Organization Sarcomere Organization Actin Filament-based Process Sarcomere Channel Activator Activity Telethonin Binding Muscle Alpha-actinin Binding Actomyosin Structure Organization Dendrite Self-avoidance Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules I Band Focal Adhesion Positive Regulation Of Potassium Ion Transport Cell-cell Adhesion Mediator Activity Sarcoplasmic Reticulum Membrane Structural Constituent Of Muscle Cytoskeleton Organization Axon Guidance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Neuron Projection Guidance Podosome Neuron Recognition Organelle Organization Sphingolipid Floppase Activity Actin Filament Uncapping Regulation Of Intracellular Transport Cytoskeletal Protein Binding Sarcoplasmic Reticulum Striated Muscle Cell Development Response To Vitamin B3 Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Titin Z Domain Binding Cytoplasmic Periphery Of The Nuclear Pore Complex Ryanodine Receptor Complex Regulation Of Potassium Ion Transport Actin Filament Regulation Of High-density Lipoprotein Particle Assembly Muscle Cell Development Phospholipase C-activating Angiotensin-activated Signaling Pathway Ryanodine-sensitive Calcium-release Channel Activity Skeletal Muscle Fiber Adaptation Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Axon Phosphatidylserine Floppase Activity
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