FHL1 and PDE4DIP

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		FHL1	PDE4DIP
Gene Name		four and a half LIM domains 1	phosphodiesterase 4D interacting protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Nucleus Cytoplasm Golgi Apparatus Centrosome Myofibril
	Molecular Function	Molecular_function Protein Binding Zinc Ion Binding Ion Channel Binding	Protein Binding Enzyme Binding
	Biological Process	Regulation Of Membrane Depolarization Muscle Organ Development Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Cellular Protein Complex Assembly
Pathways
Drugs
Diseases
GWAS			Capecitabine sensitivity ( 22864933)
Protein-Protein Interactions		19 interactors: AKAP12 CBX4 DBN1 DEAF1 EED FHL2 HES1 HIVEP3 MYBPC1 PDE4DIP PRNP RBPJ RING1 SRF SRPK1 TTN TXNIP UBE2E2 USP15	64 interactors: ADH1B AEN ANKRD11 ARNT2 BYSL C14orf105 C19orf66 C1orf109 CCDC146 CDC5L CDKN1A CHCHD3 FAM161A FAM74A4 FCHSD2 FES FHL1 GADD45G GFI1B GOLGA8EP GOLGA8F HAUS1 IMMT ITSN2 KDM1A KLC3 KLC4 KRAS KRT18 KRT31 LAMTOR3 LENG1 LMO4 MAPRE1 MIF4GD MTUS2 NAA10 NEFL NEK2 OSGEP PDE4D PFDN1 PIAS4 PPP1R18 PRNP PRPF31 RTP5 SCNM1 SDCBP SH2D4A SMN1 SNCA TFIP11 TK1 TNIK TRAF4 UTP14C VAC14 ZBTB38 ZFYVE21 ZNF408 ZNF512B ZNF581 ZSCAN26
Entrez ID		2273	9659
HPRD ID		02157	10482
Ensembl ID		ENSG00000022267	ENSG00000178104
Uniprot IDs		B7Z9A1 Q13642	F8WAP3 Q5VU43
PDB IDs		1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?		Cardiocyte Differentiation Heart Morphogenesis Aorta Morphogenesis Negative Regulation Of Transcription, DNA-templated Heart Trabecula Morphogenesis Aorta Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Muscle Structure Development Transcription, DNA-templated Regulation Of RNA Metabolic Process Striated Muscle Tissue Development Negative Regulation Of Gene Expression RNA Biosynthetic Process Muscle Cell Differentiation Cardiac Chamber Development Negative Regulation Of Biosynthetic Process Muscle Tissue Development Trabecula Morphogenesis RNA Metabolic Process Auditory Receptor Cell Fate Commitment Dorsal Aorta Morphogenesis Regulation Of Gene Expression Muscle Cell Development Artery Morphogenesis Dorsal Aorta Development Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Muscle Tissue Development Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription, DNA-templated Artery Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cardiac Muscle Cell Development Tissue Development Regulation Of Metabolic Process Cardiac Muscle Cell Myoblast Differentiation Nucleobase-containing Compound Metabolic Process Cell Development Heart Development Regulation Of Transcription From RNA Polymerase II Promoter Cardioblast Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Heart Trabecula Formation Cellular Nitrogen Compound Metabolic Process	Developmental Process Response To Copper Ion RNA Metabolic Process Anatomical Structure Development Nucleobase-containing Compound Metabolic Process Regulation Of Microtubule Polymerization Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Copper Ion Response To Mineralocorticoid Cellular Nitrogen Compound Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cell Death Regulation Of Phosphorylation Response To Glucocorticoid Regulation Of JNK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Kinase Activity Nitrogen Compound Metabolic Process Response To Corticosteroid Regulation Of Metabolic Process Regulation Of Microtubule-based Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Microtubule Polymerization Or Depolymerization Cellular Response To Epinephrine Stimulus Regulation Of Cellular Component Organization System Development Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Response To Epinephrine RNA Splicing Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Histone H3-K4 Methylation Regulation Of Kinase Activity Embryo Development Ending In Birth Or Egg Hatching MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		764g atrophy biopsy bodies boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness
Tagcloud (Difference) ?		764g atrophy biopsy bodies boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness
Tagcloud (Intersection) ?