FHL1 and DOCK9

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		FHL1	DOCK9
Name		four and a half LIM domains 1	dedicator of cytokinesis 9
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Cytosol Endomembrane System Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transmembrane Transporter Binding Metal Ion Binding Channel Activator Activity Potassium Channel Activator Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Cadherin Binding
	Biological Process	Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Small GTPase-mediated Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity
Pathways		None	CDC42 GTPase cycle RAC1 GTPase cycle Factors involved in megakaryocyte development and platelet production
Diseases		X-linked myopathy with postural muscle atrophy (XMPMA) Scapuloperoneal myopathy (SPM) Reducing body myopathy (RBM) Emery-Dreifuss muscular dystrophy	None
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Asthma (childhood onset) ( 31036433 ) Blood urea nitrogen levels ( 29403010 31152163 ) Corneal astigmatism ( 30306274 ) FEV1 ( 30804560 ) Heel bone mineral density ( 28869591 30598549 ) Lung function (FEV1/FVC) ( 30804560 ) Myocardial infarction ( 33532862 ) Nonsyndromic cleft palate ( 31609978 ) Platelet distribution width ( 32888494 ) QRS interval (sulfonylurea treatment interaction) ( 27958378 ) Refractive error ( 32231278 ) White blood cell count ( 32888494 )
Interacting Genes		30 interacting genes: APP CBX4 CHEK2 CLMN CSRP3 DBN1 DEAF1 DOCK9 EED ENO1 FHL2 HES1 HIVEP3 IGFBP5 LAMA4 MACF1 MYBPC1 NFIL3 PAX7 PDE4DIP PDLIM3 RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE ZBTB40	11 interacting genes: ATG12 CDC42 CLK1 FHL1 LNX1 MYOT NEDD9 NUCKS1 PPP2R5E SNAPIN TAF1
Entrez ID		2273	23348
HPRD ID		02157	09542
Ensembl ID		ENSG00000022267	ENSG00000088387
Uniprot IDs		B7Z9A1 Q13642 Q5JXI2	A0A0A0MT38 A0A804HIE8 A6H8Z6 B3KXE2 B7Z2G6 B9EG73 Q9BZ29 X6RGR3
PDB IDs		1X63 2CUP 2CUR 2EGQ	1WG7 2WM9 2WMN 2WMO
GO Terms Enriched among Interactors		Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Sarcomere Organization Structural Constituent Of Muscle Negative Regulation Of RNA Metabolic Process Cardiac Myofibril Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus M Band Aorta Morphogenesis Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Supramolecular Fiber Organization Myofibril Assembly Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Actin Binding Actomyosin Structure Organization Negative Regulation Of Biosynthetic Process Sex Chromatin Detection Of Muscle Stretch Telethonin Binding Cell Differentiation Negative Regulation Of Metabolic Process Transcription Corepressor Binding Z Disc Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Negative Regulation Of Macromolecule Metabolic Process Artery Morphogenesis Cadherin Binding Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Cytoskeleton Organization Heart Trabecula Formation Regulation Of Development, Heterochronic Actinin Binding Muscle Tissue Morphogenesis Muscle Alpha-actinin Binding	None