FHL1 and HIVEP3

Number of citations of the paper that reports this interaction (PMID 14999091)
6

Data Source:
BioGRID (affinity chromatography technology, two hybrid, pull down)
HPRD (two hybrid, in vivo, in vitro)

		FHL1	HIVEP3
Gene Name		four and a half LIM domains 1	human immunodeficiency virus type I enhancer binding protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Nucleus Cytoplasm
	Molecular Function	Molecular_function Protein Binding Zinc Ion Binding Ion Channel Binding	DNA Binding Metal Ion Binding
	Biological Process	Regulation Of Membrane Depolarization Muscle Organ Development Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Transcription, DNA-templated Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: AKAP12 CBX4 DBN1 DEAF1 EED FHL2 HES1 HIVEP3 MYBPC1 PDE4DIP PRNP RBPJ RING1 SRF SRPK1 TTN TXNIP UBE2E2 USP15	5 interactors: FHL1 RUNX2 TNFRSF1B TRAF1 TRAF2
Entrez ID		2273	59269
HPRD ID		02157	09442
Ensembl ID		ENSG00000022267	ENSG00000127124
Uniprot IDs		B7Z9A1 Q13642	Q5T1R4
PDB IDs		1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?		Cardiocyte Differentiation Heart Morphogenesis Aorta Morphogenesis Negative Regulation Of Transcription, DNA-templated Heart Trabecula Morphogenesis Aorta Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Muscle Structure Development Transcription, DNA-templated Regulation Of RNA Metabolic Process Striated Muscle Tissue Development Negative Regulation Of Gene Expression RNA Biosynthetic Process Muscle Cell Differentiation Cardiac Chamber Development Negative Regulation Of Biosynthetic Process Muscle Tissue Development Trabecula Morphogenesis RNA Metabolic Process Auditory Receptor Cell Fate Commitment Dorsal Aorta Morphogenesis Regulation Of Gene Expression Muscle Cell Development Artery Morphogenesis Dorsal Aorta Development Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Muscle Tissue Development Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription, DNA-templated Artery Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cardiac Muscle Cell Development Tissue Development Regulation Of Metabolic Process Cardiac Muscle Cell Myoblast Differentiation Nucleobase-containing Compound Metabolic Process Cell Development Heart Development Regulation Of Transcription From RNA Polymerase II Promoter Cardioblast Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Heart Trabecula Formation Cellular Nitrogen Compound Metabolic Process	Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Tumor Necrosis Factor Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Death Death Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Homodimerization Activity Cellular Response To Nitric Oxide Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Osteoblast Fate Commitment Regulation Of Immunoglobulin Secretion RNA Destabilization Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Membrane Protein Ectodomain Proteolysis Response To Nitric Oxide Cytokine-mediated Signaling Pathway Regulation Of Odontogenesis Of Dentin-containing Tooth Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Regulation Of Protein Homodimerization Activity Cellular Response To Organic Substance Cellular Response To Reactive Nitrogen Species Regulation Of T Cell Cytokine Production Cellular Response To BMP Stimulus Activation Of NF-kappaB-inducing Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cytokine Stimulus Osteoblast Development Regulation Of Potassium Ion Transmembrane Transporter Activity Response To Growth Factor Positive Regulation Of Potassium Ion Transport Regulation Of Odontogenesis Positive Regulation Of Chondrocyte Differentiation Immune System Process Positive Regulation Of NIK/NF-kappaB Signaling Protein K63-linked Ubiquitination Negative Regulation Of Smoothened Signaling Pathway Chondrocyte Development Protein Trimerization Regulation Of Proteolysis Positive Regulation Of Interleukin-2 Production Regulation Of Gene Expression Regulation Of Membrane Depolarization
Tagcloud ?		764g atrophy biopsy bodies boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness	alterations attracted candidates cdh13 chip coincided correlations date displaying disturbance epigenome explain h3k4me3 hpse2 il4r immunological inverse mcns microarray mononuclear nephrology nephrotic prkd2 probes q qrt trimethylation validate variations
Tagcloud (Difference) ?		764g atrophy biopsy bodies boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness	alterations attracted candidates cdh13 chip coincided correlations date displaying disturbance epigenome explain h3k4me3 hpse2 il4r immunological inverse mcns microarray mononuclear nephrology nephrotic prkd2 probes q qrt trimethylation validate variations
Tagcloud (Intersection) ?