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FHL1 and HES1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
FHL1
HES1
Description
four and a half LIM domains 1
hes family bHLH transcription factor 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
Protein-containing Complex
Molecular Function
Protein Binding
Zinc Ion Binding
Transmembrane Transporter Binding
Metal Ion Binding
Channel Activator Activity
Potassium Channel Activator Activity
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity
Transcription Corepressor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Protein Binding
JUN Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
Protein Dimerization Activity
Protein-folding Chaperone Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
N-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Muscle Organ Development
Animal Organ Morphogenesis
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cell Differentiation
Negative Regulation Of Cell Growth
Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization
Positive Regulation Of Potassium Ion Transmembrane Transport
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Cell Fate Determination
Liver Development
Inhibition Of Neuroepithelial Cell Differentiation
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Pancreatic A Cell Differentiation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Pattern Specification Process
Nervous System Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Virus
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Neuron Projection Development
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Cajal-Retzius Cell Differentiation
Neural Tube Development
Central Nervous System Neuron Differentiation
Pituitary Gland Development
Adenohypophysis Development
Neuron Differentiation
Lung Development
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Hair Cell Differentiation
Amacrine Cell Differentiation
Aorta Morphogenesis
Ascending Aorta Morphogenesis
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Protein-containing Complex Assembly
Response To Alkaloid
Positive Regulation Of DNA Binding
Cell Fate Commitment
Negative Regulation Of Cell Differentiation
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Regulation Of Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Glial Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Maturation
Regulation Of Timing Of Cell Differentiation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Negative Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Neuroendocrine Cell Differentiation
Stomach Neuroendocrine Cell Differentiation
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Fatty Acid
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Negative Regulation Of Calcium Ion Import
Response To Thyroid Hormone
Vascular Associated Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Amacrine Cell Differentiation
Response To Aroclor 1254
Negative Regulation Of Cell Fate Determination
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Negative Regulation Of Inner Ear Receptor Cell Differentiation
Pathways
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
X-linked myopathy with postural muscle atrophy (XMPMA)
Scapuloperoneal myopathy (SPM)
Reducing body myopathy (RBM)
Emery-Dreifuss muscular dystrophy
GWAS
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Interacting Genes
30 interacting genes:
APP
CBX4
CHEK2
CLMN
CSRP3
DBN1
DEAF1
DOCK9
EED
ENO1
FHL2
HES1
HIVEP3
IGFBP5
LAMA4
MACF1
MYBPC1
NFIL3
PAX7
PDE4DIP
PDLIM3
RBPJ
RING1
SRF
SRPK1
TTN
TXNIP
USP15
YWHAE
ZBTB40
36 interacting genes:
ALK
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
RUNX2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
Entrez ID
2273
3280
HPRD ID
02157
00770
Ensembl ID
ENSG00000022267
ENSG00000114315
Uniprot IDs
B7Z9A1
Q13642
Q5JXI2
Q14469
PDB IDs
1X63
2CUP
2CUR
2EGQ
2MH3
7C4O
Enriched GO Terms of Interacting Partners
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Regulation Of RNA Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Sarcomere Organization
Structural Constituent Of Muscle
Negative Regulation Of RNA Metabolic Process
Cardiac Myofibril Assembly
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cellular Developmental Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Nucleus
M Band
Aorta Morphogenesis
Chromatin Binding
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Supramolecular Fiber Organization
Myofibril Assembly
Developmental Process
Negative Regulation Of Macromolecule Biosynthetic Process
Actin Binding
Actomyosin Structure Organization
Negative Regulation Of Biosynthetic Process
Sex Chromatin
Detection Of Muscle Stretch
Telethonin Binding
Cell Differentiation
Negative Regulation Of Metabolic Process
Transcription Corepressor Binding
Z Disc
Dorsal Aorta Morphogenesis
Cardiac Muscle Cell Myoblast Differentiation
Negative Regulation Of Macromolecule Metabolic Process
Artery Morphogenesis
Cadherin Binding
Regulation Of Timing Of Cell Differentiation
Cardioblast Differentiation
Cytoskeleton Organization
Heart Trabecula Formation
Regulation Of Development, Heterochronic
Actinin Binding
Muscle Tissue Morphogenesis
Muscle Alpha-actinin Binding
Fanconi Anaemia Nuclear Complex
Regulation Of Cell Differentiation
Transcription Regulator Inhibitor Activity
Nucleus
Protein Dimerization Activity
Transcription Corepressor Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Population Proliferation
Interstrand Cross-link Repair
Animal Organ Development
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Population Proliferation
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cell Differentiation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Chromatin
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Cellular Developmental Process
Developmental Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Epithelial Cell Proliferation
Nucleoplasm
Cell Differentiation
Regulation Of Developmental Process
Circadian Rhythm
Regulation Of Primary Metabolic Process
Regulation Of Multicellular Organismal Development
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Development
Transcription Regulator Complex
Neuron Differentiation
Rhythmic Process
Animal Organ Morphogenesis
Positive Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Apoptotic Process
Response To Stress
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Gene Expression
Anatomical Structure Morphogenesis
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Tagcloud (Intersection)
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