UTP14C and NUDT15

		UTP14C	NUDT15
Description		UTP14C small subunit processome component	nudix hydrolase 15
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytosol Small-subunit Processome	Cytosol
	Molecular Function	Protein Binding	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Hydrolase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity 8-oxo-dGDP Phosphatase Activity Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity
	Biological Process	RRNA Processing Spermatogenesis Cell Differentiation Ribosome Biogenesis Meiotic Cell Cycle	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Response To Stress Purine Deoxyribonucleoside Triphosphate Catabolic Process Xenobiotic Catabolic Process DNA Protection Nucleobase-containing Small Molecule Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Phosphate bond hydrolysis by NUDT proteins Azathioprine ADME
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 31015462) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		33 interacting genes: ALAS1 BICD2 C8orf34 CARD10 CCDC57 CEP70 GCC1 GOLGA2 GOLGA6A HOOK1 HOOK2 JRK KANK2 KRT34 KRT40 LZTS2 MCC MEOX2 MTUS2 NAB2 PDE4DIP PIBF1 PRICKLE1 RABEP1 RINT1 RNF10 TEX11 TRAF1 TRAF2 TRIM27 TRIM54 TXLNA USP7	2 interacting genes: GABARAPL2 SRD5A3
Entrez ID		9724	55270
HPRD ID		12346	14848
Ensembl ID		ENSG00000253797	ENSG00000136159
Uniprot IDs		Q5TAP6	Q9NV35
PDB IDs			5BON 5LPG 6T5J 7AOM 7AOP 7B63 7B64 7B65 7B66 7B67 7B7V 7NR6 7R0D
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Cytoskeleton Organization Cytoskeleton Microtubule-based Process Centrosome Dynein Light Intermediate Chain Binding Cytoplasm Organelle Organization FHF Complex Microtubule Mitotic Spindle Assembly Protein Localization To Perinuclear Region Of Cytoplasm Microtubule Binding Thioesterase Binding Golgi Cis Cisterna Spindle Organization Cytoplasmic Microtubule Organization Regulation Of Microtubule Cytoskeleton Organization Vesicle-mediated Transport HOPS Complex Supramolecular Fiber Organization Cellular Component Assembly Regulation Of Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Microtubule Organizing Center Organization Positive Regulation Of Protein Modification Process Mitotic Spindle Organization Spindle Assembly Microtubule Organizing Center Early Endosome To Late Endosome Transport Negative Regulation Of Autophagy Golgi Organization Microtubule Nucleation Intracellular Transport Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Organelle Organization Tumor Necrosis Factor Receptor Binding TORC2 Complex Disassembly Regulation Of Microtubule-based Process Cilium Assembly Meiotic Gene Conversion Primary Ureteric Bud Growth Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Membraneless Organelle Assembly Golgi Vesicle Transport Microtubule Cytoskeleton Organization Involved In Mitosis	Protein-containing Complex Disassembly Translation Release Factor Activity, Codon Specific Mitochondrial Translational Termination Polyprenol Reductase Activity 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity 3-oxo-5-alpha-steroid 4-dehydrogenase Activity Polyprenol Catabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Polyprenal Reductase Activity DCMP Deaminase Activity Translation Release Factor Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Androgen Biosynthetic Process DNA Cytosine Deamination Translational Termination Cellular Response To Nitrogen Starvation Importin-alpha Family Protein Binding Cytidine Deaminase Activity DNA Deamination Phosphatidylethanolamine Binding Protein Localization To Endoplasmic Reticulum GABA Receptor Binding Sertoli Cell Development Dolichol-linked Oligosaccharide Biosynthetic Process Positive Regulation Of ATP-dependent Activity
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