PCM1 and TTC8

Number of citations of the paper that reports this interaction (PMID 14520415)
151

Data Source:
HPRD (in vivo)

		PCM1	TTC8
Gene Name		pericentriolar material 1	tetratricopeptide repeat domain 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Cytoplasm Centrosome Cytosol Membrane Nonmotile Primary Cilium Nuclear Membrane Centriolar Satellite Ciliary Basal Body Protein Complex	Centrosome Cytosol Cilium Photoreceptor Connecting Cilium BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	Protein Binding Identical Protein Binding	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Interkinetic Nuclear Migration Cytoplasmic Microtubule Organization Microtubule Anchoring Microtubule Anchoring At Centrosome Intraciliary Transport Involved In Cilium Morphogenesis Cilium Assembly Negative Regulation Of Neurogenesis Centrosome Organization Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Maintenance	Organelle Organization Axon Guidance Sensory Perception Of Smell Protein Transport Olfactory Bulb Development Regulation Of Protein Localization Nonmotile Primary Cilium Assembly Multicellular Organism Growth Cilium Assembly Fat Cell Differentiation Establishment Of Anatomical Structure Orientation Sensory Processing Camera-type Eye Photoreceptor Cell Differentiation Renal Tubule Development
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Economic and political preferences ( 22566634)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		17 interactors: ABI2 BBS4 CASK CCDC53 CEP131 CEP72 E2F4 EPS8 EXOC8 HAP1 ING5 KIAA0368 KRT15 KRT19 PCNT TTC8 YWHAQ	1 interactors: PCM1
Entrez ID		5108	123016
HPRD ID		02624	10484
Ensembl ID		ENSG00000078674	ENSG00000165533
Uniprot IDs		A2RUU9 E7ETA6 Q15154	B3KSL8 Q86U25 Q8TAM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Cilium Organization Cilium Morphogenesis Mitotic Cell Cycle Positive Regulation Of Cilium Assembly Sensory Processing Cell Cycle Process Mitotic Cell Cycle Process Cilium Assembly Cell Projection Organization Microtubule-based Process Organelle Assembly Cell Cycle Regulation Of Organelle Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Projection Assembly Regulation Of Microtubule-based Movement Cellular Protein Complex Localization Rac Protein Signal Transduction Organ Development Nonmotile Primary Cilium Assembly G2/M Transition Of Mitotic Cell Cycle Cytoskeleton Organization Protein Complex Localization Anatomical Structure Development Regulation Of Cilium Assembly Positive Regulation Of Transport Positive Regulation Of Organelle Assembly Brain Development Positive Regulation Of Organelle Organization Cellular Component Assembly Head Development Regulation Of Intracellular Transport Cell Projection Morphogenesis Regulation Of Microtubule-based Process Forebrain Development Cell Part Morphogenesis Developmental Process Movement Of Cell Or Subcellular Component Olfactory Bulb Development Brain Morphogenesis Central Nervous System Development Multicellular Organismal Development Olfactory Lobe Development Eye Photoreceptor Cell Differentiation Positive Regulation Of Intracellular Transport Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Positive Regulation Of Neurotrophin Production	Intraciliary Transport Involved In Cilium Morphogenesis Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Protein Localization To Centrosome Interkinetic Nuclear Migration Protein Localization To Cytoskeleton Neuronal Stem Cell Maintenance Intraciliary Transport Cytoplasmic Microtubule Organization Nucleus Localization Cell Proliferation In Forebrain Microtubule Anchoring Centrosome Organization Neural Precursor Cell Proliferation Microtubule Organizing Center Organization G2/M Transition Of Mitotic Cell Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Maintenance Of Protein Location In Cell Maintenance Of Protein Location Stem Cell Maintenance Maintenance Of Location In Cell Positive Regulation Of Intracellular Protein Transport Cilium Assembly Cilium Organization Cilium Morphogenesis Positive Regulation Of Intracellular Transport Stem Cell Development Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Protein Transport Cell Cycle Phase Transition
Tagcloud ?		9p24 allogeneic asct band bcr bridging cytogenetic discovery encouraging fusion guide hematologic highlight indispensable jak1 jak2 myeloid neoplasms occurring ongoing options p22 p24 q11 rearrangements remission ruxolitinib termed usually
Tagcloud (Difference) ?		9p24 allogeneic asct band bcr bridging cytogenetic discovery encouraging fusion guide hematologic highlight indispensable jak1 jak2 myeloid neoplasms occurring ongoing options p22 p24 q11 rearrangements remission ruxolitinib termed usually
Tagcloud (Intersection) ?