PCM1 and DENND1A

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PCM1	DENND1A
Description		pericentriolar material 1	DENN domain containing 1A
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GO Annotations	Cellular Component	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Non-motile Cilium	Cytosol Plasma Membrane Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cell Projection Organization Cytoplasmic Microtubule Organization Protein Localization To Organelle Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Regulation Of Protein Complex Stability Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Protein-containing Complex Localization To Centriolar Satellite Non-motile Cilium Assembly	Endocytosis Protein Transport Endocytic Recycling Regulation Of Rab Protein Signal Transduction
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)	Adventurousness ( 30643258) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Body mass index ( 26426971) Body mass index in non-asthmatics ( 23517042) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Depression ( 29700475) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Major depressive disorder ( 27479909) Myopia (pathological) ( 23049088) Personality dimensions ( 20691247) Polycystic ovary syndrome ( 21151128 30566500 26416764 26284813) Polycystic ovary syndrome (adjusted for age and BMI) ( 34791234) Polycystic ovary syndrome (adjusted for age) ( 34791234) Rheumatoid arthritis ( 30891314) Self-reported risk-taking behaviour ( 30271922) Suffering from nerves ( 29500382) Tea consumption ( 31046077) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)
Interacting Genes		57 interacting genes: ABI1 ABI2 AKAP9 ALG13 APP BACE2 BBS4 BICD2 CASK CCHCR1 CDC42 CDK1 CEBPA CEP72 CYTH4 DDIT3 DDX23 DENND1A DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FXR2 GABARAP GOLGA2 GRN HAP1 ING5 INTS4 KAT5 KLC1 KLC4 KRT15 KRT19 KRT24 LARP4 LSM2 MCRS1 MORF4L1 NDUFA9 PCNT PPIE PRC1 PRKCI PRPF6 RALBP1 RBM11 RBM5 RINT1 RPA2 TFIP11 TTC8 VPS26C WASHC3 ZNF830	4 interacting genes: ARF1 ARF4 ARF5 PCM1
Entrez ID		5108	57706
HPRD ID		02624	17221
Ensembl ID		ENSG00000078674	ENSG00000119522
Uniprot IDs		A0A4W8VX11 A0A5H1ZRS1 A2RUU9 B9EIS5 E9PGW9 Q15154	A0A0A0MS48 Q8TEH3 Q9HCG4
PDB IDs		6HYL 6HYM 7Q46	6EKK
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organelle Organization Cytoskeleton Organization Microtubule-based Process Centrosome Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Cytosol Spliceosomal Complex Microtubule Cytoskeleton Organization Centriolar Satellite Regulation Of Supramolecular Fiber Organization Growth Cone Microtubule Organizing Center Organization Regulation Of Organelle Organization Catalytic Step 2 Spliceosome Cellular Component Assembly Regulation Of Cell Cycle Cellular Response To Stress Microtubule Intracellular Protein Localization Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization CHOP-C/EBP Complex Regulation Of Actin Filament Organization RNA Splicing Cytoplasm Cellular Localization Astrocyte Activation Involved In Immune Response Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Sensory Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex Epithelial Cell Differentiation Protein Transport Mitotic DNA Damage Checkpoint Signaling Regulation Of Cytoskeleton Organization RNA Splicing, Via Transesterification Reactions Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Mitotic Spindle Microtubule Nucleation MRNA Processing Golgi Disassembly Nuclear DNA Replication Organelle Disassembly	GTPase Activity Cellular Localization GTP Binding Establishment Of Localization In Cell Intracellular Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intracellular Protein Localization Intracellular Protein Transport Mitotic Cleavage Furrow Ingression Cleavage Furrow Ingression Phospholipase D Activator Activity Protein-containing Complex Localization To Centriolar Satellite Plasma Membrane Bounded Cell Projection Organization Protein Transport Cell Projection Organization Interkinetic Nuclear Migration Vesicle-mediated Transport Establishment Of Protein Localization NAD+-protein-arginine ADP-ribosyltransferase Activity Cilium Assembly Golgi Vesicle Transport Intraciliary Transport Involved In Cilium Assembly Golgi Apparatus Cilium Organization Plasma Membrane Bounded Cell Projection Assembly Microtubule Anchoring At Centrosome Cell Projection Assembly Microtubule Anchoring At Microtubule Organizing Center Nucleotide Binding Intracellular Copper Ion Homeostasis Long-term Synaptic Depression Apical Protein Localization Dendritic Spine Development Regulation Of Protein Complex Stability Copper Ion Homeostasis Pericentriolar Material Neuronal Stem Cell Population Maintenance Mitotic Cytokinetic Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Extracellular Exosome Microtubule Anchoring Protein Localization To Centrosome Nuclear Migration Nucleus Localization Non-motile Cilium Golgi Membrane Dendritic Spine Organization Epidermal Growth Factor Receptor Binding Protein Localization To Organelle Ciliary Transition Zone
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