PCM1 and BBS4

Number of citations of the paper that reports this interaction (PubMedID 15107855)
0

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (in vivo, two hybrid, in vitro)

		PCM1	BBS4
Description		pericentriolar material 1	Bardet-Biedl syndrome 4
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GO Annotations	Cellular Component	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Non-motile Cilium	Pericentriolar Material Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Motile Cilium Photoreceptor Connecting Cilium Centriolar Satellite BBSome Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Membrane Non-motile Cilium
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity	Protein Binding Protein-macromolecule Adaptor Activity Dynactin Binding Alpha-tubulin Binding Beta-tubulin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cell Projection Organization Cytoplasmic Microtubule Organization Protein Localization To Organelle Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Regulation Of Protein Complex Stability Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Protein-containing Complex Localization To Centriolar Satellite Non-motile Cilium Assembly	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Neuron Migration Leukocyte Homeostasis B Cell Homeostasis Neural Tube Closure Retina Homeostasis Heart Looping Lymphocyte Homeostasis Myeloid Cell Homeostasis Negative Regulation Of Systemic Arterial Blood Pressure Centrosome Cycle Spermatid Development Sensory Perception Visual Perception Sensory Perception Of Smell Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Protein Transport Wnt Signaling Pathway Dendrite Development Regulation Of Lipid Metabolic Process Ventricular System Development Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Negative Regulation Of Actin Filament Polymerization Melanosome Transport Regulation Of Cytokinesis Leptin-mediated Signaling Pathway Protein Localization To Organelle Erythrocyte Homeostasis Microtubule Anchoring At Centrosome Social Behavior Photoreceptor Cell Outer Segment Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Positive Regulation Of Cilium Assembly Retinal Rod Cell Development Brain Morphogenesis Homeostasis Of Number Of Cells Sensory Processing Maintenance Of Protein Location In Nucleus Regulation Of Stress Fiber Assembly Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Adipose Tissue Development Fat Pad Development Protein Localization To Cilium Protein Localization To Centrosome Sperm Flagellum Assembly Regulation Of Non-motile Cilium Assembly Protein Localization To Photoreceptor Outer Segment Non-motile Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)	Body mass index ( 28448500 29273807) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Mild obesity-related type 2 diabetes ( 34737425) Theory of mind score in adolescence (Emotional Triangles Task) ( 29472613) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		57 interacting genes: ABI1 ABI2 AKAP9 ALG13 APP BACE2 BBS4 BICD2 CASK CCHCR1 CDC42 CDK1 CEBPA CEP72 CYTH4 DDIT3 DDX23 DENND1A DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FXR2 GABARAP GOLGA2 GRN HAP1 ING5 INTS4 KAT5 KLC1 KLC4 KRT15 KRT19 KRT24 LARP4 LSM2 MCRS1 MORF4L1 NDUFA9 PCNT PPIE PRC1 PRKCI PRPF6 RALBP1 RBM11 RBM5 RINT1 RPA2 TFIP11 TTC8 VPS26C WASHC3 ZNF830	23 interacting genes: ACTB BHMT CALCA CATSPERT DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 MYOG OAS1 PAX2 PCM1 RARA RARG REL SPIRE1 TOM1 TOM1L2 ZIC1
Entrez ID		5108	585
HPRD ID		02624	08982
Ensembl ID		ENSG00000078674	ENSG00000140463
Uniprot IDs		A0A4W8VX11 A0A5H1ZRS1 A2RUU9 B9EIS5 E9PGW9 Q15154	A0A0S2Z3A9 B4DQR5 Q96RK4
PDB IDs		6HYL 6HYM 7Q46	6XT9
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organelle Organization Cytoskeleton Organization Microtubule-based Process Centrosome Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Cytosol Spliceosomal Complex Microtubule Cytoskeleton Organization Centriolar Satellite Regulation Of Supramolecular Fiber Organization Growth Cone Microtubule Organizing Center Organization Regulation Of Organelle Organization Catalytic Step 2 Spliceosome Cellular Component Assembly Regulation Of Cell Cycle Cellular Response To Stress Microtubule Intracellular Protein Localization Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization CHOP-C/EBP Complex Regulation Of Actin Filament Organization RNA Splicing Cytoplasm Cellular Localization Astrocyte Activation Involved In Immune Response Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Sensory Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex Epithelial Cell Differentiation Protein Transport Mitotic DNA Damage Checkpoint Signaling Regulation Of Cytoskeleton Organization RNA Splicing, Via Transesterification Reactions Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Mitotic Spindle Microtubule Nucleation MRNA Processing Golgi Disassembly Nuclear DNA Replication Organelle Disassembly	Nucleus Localization Nuclear Migration Trachea Cartilage Development Glandular Epithelial Cell Development Centriolar Satellite DNA-binding Transcription Factor Activity Microtubule Anchoring At Centrosome Embryonic Organ Development Growth Plate Cartilage Development Positive Regulation Of Metabolic Process Cytoplasm Regulation Of Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Cytosol Response To Peptide Vesicle-mediated Transport Response To Cytokine Microtubule Anchoring At Microtubule Organizing Center Surfactant Homeostasis Cis-regulatory Region Sequence-specific DNA Binding Tube Closure Camera-type Eye Development Cellular Response To Retinoic Acid Neural Tube Closure Columnar/cuboidal Epithelial Cell Development Embryonic Camera-type Eye Development Nucleoplasm Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Biosynthetic Process Microtubule Organizing Center Positive Regulation Of Cell Development Positive Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Response To Retinoic Acid Retinoic Acid Receptor Signaling Pathway Face Development Microtubule Anchoring Positive Regulation Of Nucleobase-containing Compound Metabolic Process Organelle Localization Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Establishment Of Organelle Localization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Eye Development Protein-containing Complex Tube Formation Negative Regulation Of Cartilage Development Chromatin
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