KHDRBS2 and EWSR1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KHDRBS2	EWSR1
Description		KH RNA binding domain containing, signal transduction associated 2	EWS RNA binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cajal Body Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding SH2 Domain Binding	Nucleic Acid Binding Transcription Coregulator Activity RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome	Regulation Of DNA-templated Transcription
Pathways		PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Diseases			Extraskeletal myxoid chondrosarcoma Myxoid liposarcoma Ewing's sarcoma Clear cell sarcoma of soft tissue
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Chronotype ( 30696823) Corneal astigmatism ( 30306274) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Esophageal adenocarcinoma ( 27527254) Presence of antiphospholipid antibodies ( 27098658) Protein quantitative trait loci ( 18464913)	Breast cancer ( 23535729) Pancreatic cancer ( 25086665) Platelet count ( 27863252) Platelet distribution width ( 32888494)
Interacting Genes		54 interacting genes: AEN BAHD1 BMP7 CATSPER1 CHTOP CIRBP CNNM3 DALRD3 DOCK2 EWSR1 FOXD4L3 GRAP2 GRB2 HBZ HHEX HNRNPA0 HNRNPK HNRNPLL HNRNPR KHDRBS3 LINC01018 LMNTD2 LNX1 MSI2 MTA1 NABP1 NCOA5 NPDC1 PRMT1 PRPF31 PRR3 PSMF1 PTK6 RBFOX2 RBM10 RBM14 RBM3 RBMX RFC3 RPP30 SDCBP SF1 SF3B4 SPG7 SULT1A3 TMEM14B TYK2 TYMSOS YTHDC1 ZFC3H1 ZNF497 ZNF581 ZNF688 ZNF837	164 interacting genes: ACTL6A AGT ANXA11 ARID1A ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BRME1 BTK C11orf16 CALM1 CCDC7 CCDC91 CD177 CDK12 CEACAM5 CEBPA CETP CFAP298 CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EPAS1 ERCC5 FAM131C FASN FLI1 FXR2 GNPDA1 GPBP1L1 H2BC15 HBP1 HDAC3 HERPUD1 HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 OGT PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B PTP4A2 RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SELENOI SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SMARCC1 SMARCC2 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383
Entrez ID		202559	2130
HPRD ID		13775	00592
Ensembl ID		ENSG00000112232	ENSG00000182944
Uniprot IDs		Q5VWX1	A0A0D9SFL3 Q01844
PDB IDs			2CPE
Enriched GO Terms of Interacting Partners?		RNA Binding RNA Processing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Binding MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleus Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Splicing Factor Binding Negative Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Regulation Of Metabolic Process Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Ionizing Radiation MRNA Stabilization Negative Regulation Of Biosynthetic Process Precatalytic Spliceosome	Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Organization RNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Transcription Regulator Complex Chromatin Remodeling MRNA Metabolic Process Brahma Complex NpBAF Complex RNA Metabolic Process Regulation Of Gene Expression Nucleic Acid Binding Chromatin Single-stranded DNA Binding Protein-containing Complex Negative Regulation Of DNA-templated Transcription Cardiac Conduction System Development Chromatin Binding Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Binding MRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Nucleosome Disassembly TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process
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