KHDRBS2 and HNRNPA0

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		KHDRBS2	HNRNPA0
Description		KH RNA binding domain containing, signal transduction associated 2	heterogeneous nuclear ribonucleoprotein A0
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Synapse Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding SH2 Domain Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein Kinase Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome	MRNA Processing Inflammatory Response Response To Lipopolysaccharide 3'-UTR-mediated MRNA Stabilization
Pathways		PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Diseases
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Chronotype ( 30696823) Corneal astigmatism ( 30306274) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Esophageal adenocarcinoma ( 27527254) Presence of antiphospholipid antibodies ( 27098658) Protein quantitative trait loci ( 18464913)
Interacting Genes		54 interacting genes: AEN BAHD1 BMP7 CATSPER1 CHTOP CIRBP CNNM3 DALRD3 DOCK2 EWSR1 FOXD4L3 GRAP2 GRB2 HBZ HHEX HNRNPA0 HNRNPK HNRNPLL HNRNPR KHDRBS3 LINC01018 LMNTD2 LNX1 MSI2 MTA1 NABP1 NCOA5 NPDC1 PRMT1 PRPF31 PRR3 PSMF1 PTK6 RBFOX2 RBM10 RBM14 RBM3 RBMX RFC3 RPP30 SDCBP SF1 SF3B4 SPG7 SULT1A3 TMEM14B TYK2 TYMSOS YTHDC1 ZFC3H1 ZNF497 ZNF581 ZNF688 ZNF837	98 interacting genes: CCT3 CEBPA CEP55 CIRBP CLK1 DDX5 FILNC1 HNRNPF HNRNPH2 HNRNPH3 HNRNPK IL7R KHDRBS2 MAPK6 MAPKAPK2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MTNR1A MTNR1B NEIL3 NKX3-1 PRR3 RBM3 SLU7 SNRPA SRSF1 SUMO2 UBC
Entrez ID		202559	10949
HPRD ID		13775	17112
Ensembl ID		ENSG00000112232	ENSG00000177733
Uniprot IDs		Q5VWX1	Q13151
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding RNA Processing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Binding MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleus Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Splicing Factor Binding Negative Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Regulation Of Metabolic Process Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Ionizing Radiation MRNA Stabilization Negative Regulation Of Biosynthetic Process Precatalytic Spliceosome	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of MRNA Stability Negative Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Cytokine Production Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Motility Regulation Of Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Locomotion Regulation Of Vasculature Development Regulation Of Translation Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Migration Extracellular Space Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction
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