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DDX6 and TRIM37
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
DDX6
TRIM37
Gene Name
DEAD (Asp-Glu-Ala-Asp) box helicase 6
tripartite motif containing 37
Image
Gene Ontology Annotations
Cellular Component
Cytoplasmic MRNA Processing Body
Cytoplasm
Cytosol
Cytoplasmic Stress Granule
Membrane
RISC Complex
Intracellular Membrane-bounded Organelle
Cytoplasm
Peroxisome
Cytosol
Aggresome
ESC/E(Z) Complex
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Helicase Activity
Helicase Activity
Protein Binding
ATP Binding
Protein Domain Specific Binding
Poly(A) RNA Binding
Chromatin Binding
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Binding
Protein Homodimerization Activity
Ubiquitin Protein Ligase Activity
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Gene Expression
Cytoplasmic MRNA Processing Body Assembly
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of NF-kappaB Transcription Factor Activity
Histone H2A Monoubiquitination
Histone H2A-K119 Monoubiquitination
Negative Regulation Of Centriole Replication
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Aggresome Assembly
Pathways
mRNA decay by 5' to 3' exoribonuclease
Deadenylation-dependent mRNA decay
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Celiac disease and Rheumatoid arthritis (
21383967
)
Vitiligo (
22951725
)
Testicular germ cell tumor (
23666239
)
Protein-Protein Interactions
24 interactors:
AES
BEND7
BIRC7
CALCOCO2
CEP70
EDC3
EIF4ENIF1
GOLGA2
IKZF1
KRT40
KRTAP10-3
KRTAP10-8
NONO
PNMA5
RUNDC3A
SDCCAG3
SRPK2
TCF4
TRIM27
TRIM37
U2AF2
VPS52
ZBTB8A
ZNF24
59 interactors:
ANKRD11
APEX2
APTX
ARNT2
BYSL
CCDC33
CDC20B
CDK5RAP2
COPB1
CWF19L2
DDX6
DLGAP5
EWSR1
FAM107A
FAM124B
FAM161A
FAM50B
FXR2
KAT5
KIAA0408
KIF9
LTBR
MAGEB18
MCM10
MCRS1
NGFR
NUDT18
PBK
PNKP
PRC1
RASD1
RHPN1
RIBC2
RPL9
SCNM1
SSX2IP
TANK
TCEB3B
TNFRSF1B
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
UBASH3A
UBB
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2U
ZMAT2
ZNF329
ZNF417
ZNF655
Entrez ID
1656
4591
HPRD ID
02638
05463
Ensembl ID
ENSG00000108395
Uniprot IDs
B2R858
P26196
A8K0V9
A8K8U4
F8WEE6
O94972
PDB IDs
1VEC
2WAX
2WAY
3LRQ
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
RNA Metabolic Process
Gene Expression
Regulation Of Protein Binding
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Embryonic Digestive Tract Development
Regulation Of Nitrogen Compound Metabolic Process
MRNA Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Neutrophil Differentiation
Nuclear Speck Organization
Regulation Of Natural Killer Cell Apoptotic Process
Negative Regulation Of Protein Binding
Regulation Of Cell Death
Regulation Of Binding
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of RNA Metabolic Process
Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Cell Death
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Interleukin-2 Secretion
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Embryonic Ectodermal Digestive Tract Development
Negative Regulation Of Viral Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Histone H2A-K119 Monoubiquitination
Regulation Of MRNA Processing
RNA Splicing
Regulation Of Gene Expression
Negative Regulation Of Binding
Regulation Of RNA Splicing
Maintenance Of DNA Repeat Elements
Positive Regulation Of Anoikis
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Ectodermal Cell Differentiation
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Protein Polyubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Protein K48-linked Ubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Cellular Macromolecule Catabolic Process
Regulation Of Innate Immune Response
Protein K11-linked Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Protein K63-linked Ubiquitination
Cellular Response To Stress
Catabolic Process
Polynucleotide 3' Dephosphorylation
Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Protein Catabolic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of DNA-templated Transcription In Response To Stress
Programmed Cell Death
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Response To DNA Damage Stimulus
Regulation Of Cell Cycle Phase Transition
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteolysis
Cell Death
Death
Activation Of NF-kappaB-inducing Kinase Activity
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of NIK/NF-kappaB Signaling
Cellular Protein Catabolic Process
DNA Repair
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Proteolysis
Regulation Of Stress-activated MAPK Cascade
NIK/NF-kappaB Signaling
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Metabolic Process
Tagcloud
?
concerted
contain
continuum
cpeb
dendritic
dormant
engaged
fmrp
foci
fus
granules
hud
masked
messengers
mrnas
polysomes
pumilio
rbps
repressed
smaug
stalled
staufen
synapse
thousands
tls
transcriptome
translational
trapped
zbp1
Tagcloud (Difference)
?
concerted
contain
continuum
cpeb
dendritic
dormant
engaged
fmrp
foci
fus
granules
hud
masked
messengers
mrnas
polysomes
pumilio
rbps
repressed
smaug
stalled
staufen
synapse
thousands
tls
transcriptome
translational
trapped
zbp1
Tagcloud (Intersection)
?