DDX6

Gene Name		DEAD (Asp-Glu-Ala-Asp) box helicase 6
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Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane RISC Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Protein Domain Specific Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression Cytoplasmic MRNA Processing Body Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967) Vitiligo ( 22951725)
Protein-protein Interactions		24 interactors: AES BEND7 BIRC7 CALCOCO2 CEP70 EDC3 EIF4ENIF1 GOLGA2 IKZF1 KRT40 KRTAP10-3 KRTAP10-8 NONO PNMA5 RUNDC3A SDCCAG3 SRPK2 TCF4 TRIM27 TRIM37 U2AF2 VPS52 ZBTB8A ZNF24
Entrez ID		1656
HPRD ID		02638
Ensembl ID
Uniprot IDs		B2R858 P26196
PDB IDs		1VEC 2WAX 2WAY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Protein Binding Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Embryonic Digestive Tract Development Regulation Of Nitrogen Compound Metabolic Process MRNA Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Neutrophil Differentiation Nuclear Speck Organization Regulation Of Natural Killer Cell Apoptotic Process Negative Regulation Of Protein Binding Regulation Of Cell Death Regulation Of Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Negative Regulation Of Interleukin-2 Secretion Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Embryonic Ectodermal Digestive Tract Development Negative Regulation Of Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Histone H2A-K119 Monoubiquitination Regulation Of MRNA Processing RNA Splicing Regulation Of Gene Expression Negative Regulation Of Binding Regulation Of RNA Splicing Maintenance Of DNA Repeat Elements Positive Regulation Of Anoikis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Ectodermal Cell Differentiation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Tagcloud ?		concerted contain continuum cpeb dendritic dormant engaged fmrp foci fus granules hud masked messengers mrnas polysomes pumilio rbps repressed smaug stalled staufen synapse thousands tls transcriptome translational trapped zbp1