DDX6 and EDC3

Number of citations of the paper that reports this interaction (PMID 16364915)
154

Data Source:
HPRD (in vivo, in vitro)

		DDX6	EDC3
Gene Name		DEAD (Asp-Glu-Ala-Asp) box helicase 6	enhancer of mRNA decapping 3
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane RISC Complex Intracellular Membrane-bounded Organelle	Cytoplasmic MRNA Processing Body Cytosol Membrane
	Molecular Function	RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Protein Domain Specific Binding Poly(A) RNA Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression Cytoplasmic MRNA Processing Body Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967) Vitiligo ( 22951725)	Caffeine consumption ( 21490707)
Protein-Protein Interactions		24 interactors: AES BEND7 BIRC7 CALCOCO2 CEP70 EDC3 EIF4ENIF1 GOLGA2 IKZF1 KRT40 KRTAP10-3 KRTAP10-8 NONO PNMA5 RUNDC3A SDCCAG3 SRPK2 TCF4 TRIM27 TRIM37 U2AF2 VPS52 ZBTB8A ZNF24	7 interactors: ANXA10 DCP1B DDX6 EFHC2 YWHAB YWHAG ZFP36
Entrez ID		1656	80153
HPRD ID		02638	07954
Ensembl ID			ENSG00000179151
Uniprot IDs		B2R858 P26196	Q96F86
PDB IDs		1VEC 2WAX 2WAY	2VC8 2WAX 2WAY 3D3J 3D3K
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Protein Binding Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Embryonic Digestive Tract Development Regulation Of Nitrogen Compound Metabolic Process MRNA Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Neutrophil Differentiation Nuclear Speck Organization Regulation Of Natural Killer Cell Apoptotic Process Negative Regulation Of Protein Binding Regulation Of Cell Death Regulation Of Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Negative Regulation Of Interleukin-2 Secretion Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Embryonic Ectodermal Digestive Tract Development Negative Regulation Of Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Histone H2A-K119 Monoubiquitination Regulation Of MRNA Processing RNA Splicing Regulation Of Gene Expression Negative Regulation Of Binding Regulation Of RNA Splicing Maintenance Of DNA Repeat Elements Positive Regulation Of Anoikis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Ectodermal Cell Differentiation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Aromatic Compound Catabolic Process MRNA Metabolic Process Regulation Of Mitochondrion Organization Negative Regulation Of Cellular Protein Metabolic Process Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Cellular Macromolecule Catabolic Process Negative Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Intracellular Transport Negative Regulation Of Protein Dephosphorylation Response To Insulin Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cellular Response To Peptide Gene Expression Apoptotic Signaling Pathway Cytoplasmic MRNA Processing Body Assembly 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Destabilization Positive Regulation Of Organelle Organization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Protein Targeting Positive Regulation Of MRNA 3'-end Processing Regulation Of Intracellular Transport Regulation Of MRNA 3'-end Processing Response To Peptide Hormone Cellular Response To Organonitrogen Compound Catabolic Process Response To Peptide Positive Regulation Of MRNA Catabolic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Cytoplasmic Sequestering Of Protein Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Stabilization Cellular Response To Hormone Stimulus
Tagcloud ?		concerted contain continuum cpeb dendritic dormant engaged fmrp foci fus granules hud masked messengers mrnas polysomes pumilio rbps repressed smaug stalled staufen synapse thousands tls transcriptome translational trapped zbp1	bodies bottom build calorimetry clustering combines crystallography dcp1 dcp2 decapping details foci helical interferes intermolecular isothermal leucine lsm machinery pdc1 pombe prime reconstitute scaffolding schizosaccharomyces titration transitions undergo undetermined
Tagcloud (Difference) ?		concerted contain continuum cpeb dendritic dormant engaged fmrp fus granules hud masked messengers mrnas polysomes pumilio rbps repressed smaug stalled staufen synapse thousands tls transcriptome translational trapped zbp1	bodies bottom build calorimetry clustering combines crystallography dcp1 dcp2 decapping details helical interferes intermolecular isothermal leucine lsm machinery pdc1 pombe prime reconstitute scaffolding schizosaccharomyces titration transitions undergo undetermined
Tagcloud (Intersection) ?		foci