DDX6 and CNKSR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DDX6	CNKSR3
Description		DEAD-box helicase 6	CNKSR family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Heterochromatin P-body Outer Dense Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Cytoplasmic Stress Granule Membrane RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Concave Side Of Sperm Head Sperm Annulus	Cytoplasm Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Domain Specific Binding Cadherin Binding	Protein Binding
	Biological Process	Spermatogenesis Negative Regulation Of Translation Viral RNA Genome Packaging Stem Cell Population Maintenance Neuron Differentiation P-body Assembly Stress Granule Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation Spermatid Differentiation	Regulation Of Signal Transduction Positive Regulation Of Sodium Ion Transport Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		mRNA decay by 5' to 3' exoribonuclease
Drugs		D-tartaric acid
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 30929738 31619474 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Blood protein levels ( 30072576) Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Diffuse cutaneous systemic sclerosis ( 24387989) Height ( 25429064) Hip minimal joint space width ( 27701424) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 19838195 28714469) Systemic sclerosis ( 31672989 24387989) Vitiligo ( 22951725)	Diabetic kidney disease ( 26305897) Estimated glomerular filtration rate ( 31152163) Lipoprotein (a) levels ( 26377243) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Nontraumatic osteonecrosis of the femoral head ( 32701715) Parkinson's disease ( 22451204) Renal function-related traits (eGRFcrea) ( 22797727) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		75 interacting genes: BEGAIN BEND7 BIRC7 CALCOCO2 CCDC136 CCDC14 CEBPA CEP70 CEP76 CNKSR3 CNOT1 DDX17 DES DISC1 DNAAF11 EDC3 EFHC2 ENTR1 FCHO1 GOLGA2 GPRASP3 HOOK2 IK IKZF1 INKA1 JAKMIP1 JUP KLC4 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LZTS1 MAGED1 MESD MTUS2 NAB2 NONO PAK5 PDLIM7 PICK1 PNMA5 POU6F2 PRDM16 PRPH RAPGEF3 RBM11 RBM14 REL RO60 RUNDC3A SCYL1 SHMT1 SLAIN1 SORBS3 SPATA6 SRPK2 STAT1 TCF12 TCF4 TLE5 TP53BP2 TRAF2 TRIM27 TRIM37 TRIM54 U2AF2 USH1G VPS52 ZBTB10 ZBTB14 ZBTB43 ZBTB8A ZC2HC1C ZNF24	10 interacting genes: AKT1 CDKN2B DDX6 DLL1 EIF4A3 FAM76B GPKOW JRK N4BP3 NMI
Entrez ID		1656	154043
HPRD ID		02638	14349
Ensembl ID		ENSG00000110367	ENSG00000153721
Uniprot IDs		B2R858 P26196	A0A5H1ZRR2 Q6P9H4
PDB IDs		1VEC 2WAX 2WAY 4CRW 4CT4 4CT5 5ANR 6F9S 6S8S
Enriched GO Terms of Interacting Partners?		Cytoskeleton Identical Protein Binding Protein Binding Intermediate Filament Cytoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Microtubule Nuclear Speck Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Centriole Replication Transcription Coactivator Activity Intermediate Filament Organization Regulation Of MRNA Processing Regulation Of RNA Metabolic Process Cytosol Negative Regulation Of Centriole Replication Aggresome Tumor Necrosis Factor Receptor Binding Negative Regulation Of Metabolic Process Regulation Of Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of Organelle Organization Regulation Of MRNA Metabolic Process Centrosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament	Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Gene Expression Response To Nerve Growth Factor Negative Regulation Of Notch Signaling Pathway Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Maintenance Of Protein Location Cell Surface Pattern Recognition Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of TRNA Methylation Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location In Cell Cellular Response To Nerve Growth Factor Stimulus Concave Side Of Sperm Head Nucleic Acid Binding MRNA Binding Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Cerebellar Molecular Layer Formation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Maintenance Of Location In Cell Regulation Of MRNA Metabolic Process RNA Helicase Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Notch Signaling Pathway Negative Regulation Of RNA Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Translation Response To Insulin-like Growth Factor Stimulus Maintenance Of Location Positive Regulation Of Cell Communication Mammalian Oogenesis Stage Positive Regulation Of Signaling Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TRNA (guanine-N7)-methylation Negative Regulation Of Macromolecule Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Signal Transduction RNA Stabilization Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum Cellular Response To Cell-matrix Adhesion Stem Cell Population Maintenance
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