ZNF564 and ALAS1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ZNF564	ALAS1
Gene Name		zinc finger protein 564	5-aminolevulinate synthase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	DNA Binding Metal Ion Binding	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process
Pathways		Generic Transcription Pathway	PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs			Pyridoxal Phosphate Glycine
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		23 interactors: ALAS1 CALCOCO2 CCDC136 CCDC85B CCNDBP1 GOPC KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LDOC1 MAGEA1 MDFI MEOX2 MID2 PNMA1 REL RPGRIP1 SPERT TADA2A TRAF1 TRIM23 TRIM41	40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		163050	211
HPRD ID		10338	00505
Ensembl ID		ENSG00000249709	ENSG00000023330
Uniprot IDs		Q8TBZ8	P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasmic Sequestering Of Protein Cytoplasmic Sequestering Of CFTR Protein Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Biosynthetic Process	Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity
Tagcloud ?			adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Difference) ?			adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Intersection) ?