DGKA and SREK1

Number of citations of the paper that reports this interaction (PubMedID 14559993)
73

Data Source:
HPRD (two hybrid)

		DGKA	SREK1
Description		diacylglycerol kinase alpha	splicing regulatory glutamic acid and lysine rich protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity Calcium Ion Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding Alkylglycerol Kinase Activity	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation	MRNA Processing RNA Splicing
Pathways		Effects of PIP2 hydrolysis
Drugs		Vitamin E alpha-Tocopherol succinate
Diseases
GWAS		Anorexia nervosa ( 28494655) Refractive error ( 32231278) Vitiligo ( 22951725)	Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)
Interacting Genes		3 interacting genes: IL21 SRC SREK1	66 interacting genes: ARL6IP4 CD8A CKAP2 CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 MRPL37 NAT10 NCL NPM1 PABPC1 PABPC4 PARP1 PCBP3 PIN1 PRPF40A RAB5C RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRRM4 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2
Entrez ID		1606	140890
HPRD ID		00517	18043
Ensembl ID		ENSG00000065357	ENSG00000153914
Uniprot IDs		P23743	Q8WXA9
PDB IDs		1TUZ 6IIE
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Phosphorylation Regulation Of Tissue Remodeling Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Neutrophil Activation Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Caveolin-mediated Endocytosis Regulation Of T Cell Activation Connexin Binding Regulation Of Lamellipodium Morphogenesis Positive Regulation Of Dephosphorylation Positive Regulation Of Cell Activation Cellular Response To Progesterone Stimulus Positive Regulation Of Protein Phosphorylation Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Signal Complex Assembly Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Positive Regulation Of Integrin Activation Osteoclast Development Phospholipase Activator Activity Positive Regulation Of Phosphorylation Protein Phosphorylation Cell Activation Involved In Immune Response Regulation Of Phosphorylation Positive Regulation Of Innate Immune Response Leukocyte Activation Involved In Immune Response Regulation Of Neutrophil Activation Regulation Of Innate Immune Response Progesterone Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Neutrophil Activation Involved In Immune Response BMP Receptor Binding Immune Effector Process Positive Regulation Of Lamellipodium Morphogenesis Signaling Receptor Activator Activity Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Differentiation Interleukin-2 Receptor Binding	RNA Splicing RNA Binding MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Nuclear Speck Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Ribonucleoprotein Complex Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Gene Expression Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Alternative MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Pre-mRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process
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