DGKA and IL21

Number of citations of the paper that reports this interaction (PMID 8626603)
20

Data Source:
HPRD (in vivo)

		DGKA	IL21
Gene Name		diacylglycerol kinase, alpha 80kDa	interleukin 21
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Extracellular Space
	Molecular Function	NAD+ Kinase Activity Diacylglycerol Kinase Activity Calcium Ion Binding ATP Binding Phospholipid Binding	Cytokine Activity Cytokine Receptor Binding Interleukin-2 Receptor Binding
	Biological Process	Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Phosphorylation Platelet Activation Intracellular Signal Transduction	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Maturation Positive Regulation Of Inflammatory Response
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS		Vitiligo ( 22951725)	Alopecia areata ( 20596022) Celiac disease ( 20190752 17558408 18311140) Inflammatory bowel disease ( 23128233) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 20453842) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		3 interactors: IL21 SRC SREK1	3 interactors: DGKA FBXO25 IL21R
Entrez ID		1606	59067
HPRD ID		00517	05650
Ensembl ID		ENSG00000065357	ENSG00000138684
Uniprot IDs		P23743	Q9HBE4
PDB IDs		1TUZ	2OQP 3TGX
Enriched GO Terms of Interacting Partners?		Regulation Of Tissue Remodeling Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of T Cell Activation Cellular Response To Progesterone Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Podosome Assembly Regulation Of Lymphocyte Activation Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Osteoclast Development Negative Regulation Of Protein Oligomerization Regulation Of Cell Activation Positive Regulation Of Interleukin-17 Production Regulation Of Integrin Activation Positive Regulation Of Interferon-gamma Biosynthetic Process Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cytokine Production Positive Regulation Of Natural Killer Cell Differentiation Transcytosis Signal Complex Assembly Stress Fiber Assembly Negative Regulation Of Anoikis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Adhesion Uterus Development Positive Regulation Of Immune Response Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Anoikis Response To Acidic PH Regulation Of Mitochondrial Depolarization Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Focal Adhesion Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor	Interleukin-21-mediated Signaling Pathway Cell Activation
Tagcloud ?			6r adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il6r intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper
Tagcloud (Difference) ?			6r adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il6r intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper
Tagcloud (Intersection) ?