DGKA and IL21

Number of citations of the paper that reports this interaction (PubMedID 8626603)
0

Data Source:
HPRD (in vivo)

		DGKA	IL21
Description		diacylglycerol kinase alpha	interleukin 21
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity Calcium Ion Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding Alkylglycerol Kinase Activity	Cytokine Activity Cytokine Receptor Binding Interleukin-2 Receptor Binding Protein Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation	Natural Killer Cell Differentiation Positive Regulation Of Cytokine Production Germinal Center B Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cell Population Proliferation Response To Virus Positive Regulation Of B Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Development Cell Maturation Positive Regulation Of Inflammatory Response Positive Regulation Of Lymphocyte Activation Defense Response To Virus T Follicular Helper Cell Differentiation Defense Response To Other Organism Cellular Response To Virus
Pathways		Effects of PIP2 hydrolysis	Interleukin-21 signaling
Drugs		Vitamin E alpha-Tocopherol succinate
Diseases			Type I diabetes mellitus
GWAS		Anorexia nervosa ( 28494655) Refractive error ( 32231278) Vitiligo ( 22951725)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alopecia areata ( 20596022 25608926) Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23727859 25574825 26482879) Bipolar disorder ( 31043756) Celiac disease ( 22057235 17558408 24999842 20190752 18311140) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mosquito bite size ( 28199695) Night sleep phenotypes ( 27126917) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 23603763 27992413) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 30423114 24390342) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 25751624) Ulcerative colitis ( 21297633) Vaso-occlusive pain in sickle-cell anemia ( 28584135)
Interacting Genes		3 interacting genes: IL21 SRC SREK1	6 interacting genes: ASPH DGKA FBXO25 IL21R S100A6 S100P
Entrez ID		1606	59067
HPRD ID		00517	05650
Ensembl ID		ENSG00000065357	ENSG00000138684
Uniprot IDs		P23743	A0A224B028 Q9HBE4
PDB IDs		1TUZ 6IIE	2OQP 3TGX 8ENT
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Phosphorylation Regulation Of Tissue Remodeling Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Neutrophil Activation Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Caveolin-mediated Endocytosis Regulation Of T Cell Activation Connexin Binding Regulation Of Lamellipodium Morphogenesis Positive Regulation Of Dephosphorylation Positive Regulation Of Cell Activation Cellular Response To Progesterone Stimulus Positive Regulation Of Protein Phosphorylation Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Signal Complex Assembly Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Positive Regulation Of Integrin Activation Osteoclast Development Phospholipase Activator Activity Positive Regulation Of Phosphorylation Protein Phosphorylation Cell Activation Involved In Immune Response Regulation Of Phosphorylation Positive Regulation Of Innate Immune Response Leukocyte Activation Involved In Immune Response Regulation Of Neutrophil Activation Regulation Of Innate Immune Response Progesterone Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Neutrophil Activation Involved In Immune Response BMP Receptor Binding Immune Effector Process Positive Regulation Of Lamellipodium Morphogenesis Signaling Receptor Activator Activity Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Differentiation Interleukin-2 Receptor Binding	Calcium Ion Binding Calcium-dependent Protein Binding Interleukin-21 Receptor Activity Interleukin-21-mediated Signaling Pathway Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Alkylglycerol Kinase Activity
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