DGKA

Gene Name		diacylglycerol kinase, alpha 80kDa
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Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane
	Molecular Function	NAD+ Kinase Activity Diacylglycerol Kinase Activity Calcium Ion Binding ATP Binding Phospholipid Binding
	Biological Process	Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Phosphorylation Platelet Activation Intracellular Signal Transduction
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS		Vitiligo ( 22951725)
Protein-protein Interactions		3 interactors: IL21 SRC SREK1
Entrez ID		1606
HPRD ID		00517
Ensembl ID		ENSG00000065357
Uniprot IDs		P23743
PDB IDs		1TUZ
Enriched GO Terms of Interacting Partners?		Regulation Of Tissue Remodeling Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of T Cell Activation Cellular Response To Progesterone Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Podosome Assembly Regulation Of Lymphocyte Activation Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Osteoclast Development Negative Regulation Of Protein Oligomerization Regulation Of Cell Activation Positive Regulation Of Interleukin-17 Production Regulation Of Integrin Activation Positive Regulation Of Interferon-gamma Biosynthetic Process Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cytokine Production Positive Regulation Of Natural Killer Cell Differentiation Transcytosis Signal Complex Assembly Stress Fiber Assembly Negative Regulation Of Anoikis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Adhesion Uterus Development Positive Regulation Of Immune Response Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Anoikis Response To Acidic PH Regulation Of Mitochondrial Depolarization Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Focal Adhesion Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor
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