DGKA

Description		diacylglycerol kinase alpha
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity Calcium Ion Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding Alkylglycerol Kinase Activity
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation
Pathways		Effects of PIP2 hydrolysis
Drugs		Vitamin E alpha-Tocopherol succinate
Diseases
GWAS		Anorexia nervosa ( 28494655) Refractive error ( 32231278) Vitiligo ( 22951725)
Interacting Genes		3 interacting genes: IL21 SRC SREK1
Entrez ID		1606
HPRD ID		00517
Ensembl ID		ENSG00000065357
Uniprot IDs		P23743
PDB IDs		1TUZ 6IIE
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Phosphorylation Regulation Of Tissue Remodeling Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Neutrophil Activation Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Caveolin-mediated Endocytosis Regulation Of T Cell Activation Connexin Binding Regulation Of Lamellipodium Morphogenesis Positive Regulation Of Dephosphorylation Positive Regulation Of Cell Activation Cellular Response To Progesterone Stimulus Positive Regulation Of Protein Phosphorylation Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Signal Complex Assembly Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Positive Regulation Of Integrin Activation Osteoclast Development Phospholipase Activator Activity Positive Regulation Of Phosphorylation Protein Phosphorylation Cell Activation Involved In Immune Response Regulation Of Phosphorylation Positive Regulation Of Innate Immune Response Leukocyte Activation Involved In Immune Response Regulation Of Neutrophil Activation Regulation Of Innate Immune Response Progesterone Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Neutrophil Activation Involved In Immune Response BMP Receptor Binding Immune Effector Process Positive Regulation Of Lamellipodium Morphogenesis Signaling Receptor Activator Activity Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Differentiation Interleukin-2 Receptor Binding
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