TRIM28 and SMARCAD1

Number of citations of the paper that reports this interaction (PubMedID 37761933)
99

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TRIM28	SMARCAD1
Description		tripartite motif containing 28	SNF2 related chromatin remodeling ATPase with DExD box 1
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GO Annotations	Cellular Component	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Site Of Double-strand Break Nuclear Replication Fork
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Ligase Activity Chromo Shadow Domain Binding Promoter-specific Chromatin Binding	Nucleotide Binding DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Epithelial To Mesenchymal Transition DNA Repair Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Embryo Implantation Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Protein Import Into Nucleus Epigenetic Programming Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Genomic Imprinting	Regulation Of DNA Recombination DNA Double-strand Break Processing DNA Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Positive Regulation Of Transcription By RNA Polymerase II Chromosome Separation
Pathways		Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Capecitabine sensitivity ( 22864933) Colorectal cancer or advanced adenoma ( 30510241) Cortical surface area (MOSTest) ( 32665545) Hand grip strength ( 29691431) Heel bone mineral density ( 28869591 30598549) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 25231870) QT interval ( 24952745 29874175) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604732 28604728 23666239) Type 2 diabetes ( 30297969)
Interacting Genes		90 interacting genes: CBX1 CBX3 CBX5 CCAR2 CDC34 CDC42 CDCA4 CDKN2A CEBPB CHAF1A CHD3 EAF1 ESR1 FBP1 FES H4C1 HDAC10 HTRA2 IRF1 IRF7 LIN28A LINC00624 LYN MAGEA2 MAGEA2B MAGEA6 MAGEC2 MAGED1 MAPKAPK2 MCM3 MCM5 MORC2 MYB NR3C1 NR4A1 NR4A3 NSMCE3 OGT PFDN5 PHF13 PPP2CA PRKAA1 PTEN RB1 RFC4 RNF4 SERTAD1 SERTAD2 SETDB1 SIN3A SIRT1 SKI SMARCAD1 SMURF2 SPG7 STAT3 SUMO2 TP73 TRIM24 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2L6 UBE2N UBE2U UBE3D URI1 VHL VIM YWHAQ ZBTB33 ZNF10 ZNF133 ZNF197 ZNF274 ZNF354A ZNF354C ZNF382 ZNF420 ZNF496 ZNF689 ZNF74 ZNF93	7 interacting genes: CBS GTF3C3 PCNA SUMO1 SUMO2 TOPBP1 TRIM28
Entrez ID		10155	56916
HPRD ID		03445	11586
Ensembl ID		ENSG00000130726	ENSG00000163104
Uniprot IDs		Q13263	Q9H4L7
PDB IDs		1FP0 2RO1 2YVR 6H3A 6I9H 6QAJ 6QU1 7Z36	6H3A 6QU1 7Z36
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Ubiquitin Conjugating Enzyme Activity Nucleoplasm Cellular Response To Stress DNA Damage Response Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein-containing Complex PML Body DNA Binding Positive Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Protein Ubiquitination Macromolecule Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Response To Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Binding Protein Catabolic Process Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein K48-linked Ubiquitination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific	Nucleic Acid Metabolic Process Protein Sumoylation DNA Metabolic Process Ubiquitin Protein Ligase Binding Nucleobase-containing Compound Metabolic Process PML Body Protein Tag Activity Macromolecule Metabolic Process SUMO Transferase Activity DNA Repair Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Response To Cadmium Ion DNA Damage Response Male Germ Cell Nucleus Cellular Response To Stress PCNA Complex Replisome Regulation Of Protein Import Into Nucleus Leukocyte Adhesion To Arterial Endothelial Cell Mitochondrial Manganese Ion Transmembrane Transport Zinc:bicarbonate Symporter Activity Iron Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Mercury Ion Transport Nuclear Body Enzyme Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cysteine Biosynthetic Process From Serine Cystathionine Beta-synthase Activity PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Krueppel-associated Box Domain Binding Broken Chromosome Clustering Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Carbon Monoxide Binding Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport Protein Localization To Nuclear Pore Ubiquitin-like Protein Ligase Activity Cellular Detoxification Of Cadmium Ion Cysteine Biosynthetic Process L-serine Catabolic Process Transsulfuration Homocysteine Catabolic Process
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