TRIM28 and PHF13

Number of citations of the paper that reports this interaction (PubMedID 23034801)
75

Data Source:
BioGRID (pull down)

		TRIM28	PHF13
Description		tripartite motif containing 28	PHD finger protein 13
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GO Annotations	Cellular Component	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Ligase Activity Chromo Shadow Domain Binding Promoter-specific Chromatin Binding	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity Chromatin-protein Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Epithelial To Mesenchymal Transition DNA Repair Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Embryo Implantation Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Protein Import Into Nucleus Epigenetic Programming Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Genomic Imprinting	Mitotic Cell Cycle Chromatin Organization DNA Damage Response Chromosome Segregation Mitotic Chromosome Condensation Chromosome Condensation Cell Division
Pathways		Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Peak expiratory flow ( 30804560)
Interacting Genes		90 interacting genes: CBX1 CBX3 CBX5 CCAR2 CDC34 CDC42 CDCA4 CDKN2A CEBPB CHAF1A CHD3 EAF1 ESR1 FBP1 FES H4C1 HDAC10 HTRA2 IRF1 IRF7 LIN28A LINC00624 LYN MAGEA2 MAGEA2B MAGEA6 MAGEC2 MAGED1 MAPKAPK2 MCM3 MCM5 MORC2 MYB NR3C1 NR4A1 NR4A3 NSMCE3 OGT PFDN5 PHF13 PPP2CA PRKAA1 PTEN RB1 RFC4 RNF4 SERTAD1 SERTAD2 SETDB1 SIN3A SIRT1 SKI SMARCAD1 SMURF2 SPG7 STAT3 SUMO2 TP73 TRIM24 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2L6 UBE2N UBE2U UBE3D URI1 VHL VIM YWHAQ ZBTB33 ZNF10 ZNF133 ZNF197 ZNF274 ZNF354A ZNF354C ZNF382 ZNF420 ZNF496 ZNF689 ZNF74 ZNF93	2 interacting genes: CPTP TRIM28
Entrez ID		10155	148479
HPRD ID		03445	10150
Ensembl ID		ENSG00000130726	ENSG00000116273
Uniprot IDs		Q13263	A0A158RFV6 Q86YI8
PDB IDs		1FP0 2RO1 2YVR 6H3A 6I9H 6QAJ 6QU1 7Z36	3O70 3O7A
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Ubiquitin Conjugating Enzyme Activity Nucleoplasm Cellular Response To Stress DNA Damage Response Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein-containing Complex PML Body DNA Binding Positive Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Protein Ubiquitination Macromolecule Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Response To Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Binding Protein Catabolic Process Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein K48-linked Ubiquitination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific	Convergent Extension Involved In Axis Elongation Ubiquitin-like Protein Ligase Activity Krueppel-associated Box Domain Binding Embryonic Placenta Morphogenesis Chromo Shadow Domain Binding Ceramide 1-phosphate Transport Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity Glycolipid Transport Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Convergent Extension Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Lipid Transfer Activity Suppression Of Viral Release By Host Ceramide Transport Negative Regulation Of NLRP3 Inflammasome Complex Assembly SUMO Transferase Activity Genomic Imprinting Epigenetic Programming Of Gene Expression Positive Regulation Of Protein Import Into Nucleus DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-1 Beta Production Intermembrane Lipid Transfer Nuclear Outer Membrane Embryo Implantation Negative Regulation Of Viral Genome Replication Regulation Of NLRP3 Inflammasome Complex Assembly Protein Sumoylation Heterochromatin Constitutive Heterochromatin Formation Euchromatin Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport
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