CRYBB2 and CRYAA

Number of citations of the paper that reports this interaction (PMID 11700327)
21

Data Source:
HPRD (in vitro)

		CRYBB2	CRYAA
Gene Name		crystallin, beta B2	crystallin, alpha A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Identical Protein Binding Protein Homodimerization Activity	Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Visual Perception Camera-type Eye Development Response To Stimulus	Visual Perception Negative Regulation Of Intracellular Transport Protein Refolding Negative Regulation Of Apoptotic Process Response To Stimulus Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CRYAA CRYAB CRYBA1 CRYBA2 CRYBA4 CRYGC HSPB1 MIP	17 interactors: ALB BCL2L1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS GORASP2 HSPB1 HSPB2 LALBA MIP SDCBP SPG21 WDYHV1
Entrez ID		1415	1409
HPRD ID		00430	00427
Ensembl ID		ENSG00000244752	ENSG00000160202
Uniprot IDs		P43320 R4UMM2	E9PHE4 P02489
PDB IDs		1YTQ
Enriched GO Terms of Interacting Partners?		Camera-type Eye Development Eye Development Visual Perception Sensory Perception Of Light Stimulus Sensory Organ Development Lens Development In Camera-type Eye Sensory Perception Neurological System Process Organ Development System Development Negative Regulation Of Intracellular Transport Multicellular Organismal Development Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Anatomical Structure Development Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Canalicular Bile Acid Transport Protein Processing Involved In Protein Targeting To Mitochondrion Tubulin Complex Assembly Negative Regulation Of Apoptotic Process Developmental Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Endothelial Cell Chemotaxis Protein Homooligomerization Negative Regulation Of Cell Death Bile Acid Secretion Glycerol Transport Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Mitochondrial Protein Processing Polyol Transport Cellular Water Homeostasis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Transport	Visual Perception Sensory Perception Of Light Stimulus Camera-type Eye Development Eye Development Lens Development In Camera-type Eye Sensory Organ Development Sensory Perception Cellular Response To Gamma Radiation Neurological System Process Bile Acid And Bile Salt Transport Response To Gamma Radiation Cellular Response To Ionizing Radiation Apoptotic Process In Bone Marrow Retina Homeostasis Maintenance Of Mitochondrion Location Lactose Biosynthetic Process Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Stimulus Interaction With Host Organ Development Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Suppression By Virus Of Host Apoptotic Process Anatomical Structure Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Disaccharide Metabolic Process Canalicular Bile Acid Transport Positive Regulation Of Behavior Monocarboxylic Acid Transport Response To Unfolded Protein Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Cell Death Cellular Response To Radiation System Development Response To Ionizing Radiation Protein Processing Involved In Protein Targeting To Mitochondrion Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Mitochondrial Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Tubulin Complex Assembly Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Stress
Tagcloud ?		abnormality acuity adcc adulthood arranged autosomal blindness blue bluish cataract cataracts cerulean concentric congenital cousin crystallin daughter familial lens mapped mating mildly occasional opacifications opacities presumed radially studying termination	aiims beaded bfsp1 cataract congenital cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygs crystallin cx d85n delhi e155k e75k expands filament fourteen gja3 gja8 m1v ophthalmic sciences studio transparency y67n
Tagcloud (Difference) ?		abnormality acuity adcc adulthood arranged autosomal blindness blue bluish cataracts cerulean concentric cousin daughter familial lens mapped mating mildly occasional opacifications opacities presumed radially studying termination	aiims beaded bfsp1 cryab cryba1 cryba4 crybb1 crybb3 crygs cx d85n delhi e155k e75k expands filament fourteen gja3 gja8 m1v ophthalmic sciences studio transparency y67n
Tagcloud (Intersection) ?		cataract congenital crybb2 crystallin