CRYBB2 and CRYAA

Number of citations of the paper that reports this interaction (PubMedID 11700327)
0

Data Source:
HPRD (in vitro)

		CRYBB2	CRYAA
Description		crystallin beta B2	crystallin alpha A
Image
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Lens Development In Camera-type Eye Visual Perception Camera-type Eye Development	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis
Pathways
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678)	Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		9 interacting genes: CRYAA CRYAB CRYBA1 CRYBA2 CRYBA4 CRYGC HSPB1 LMO4 MIP	134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20
Entrez ID		1415	1409
HPRD ID		00430	00427
Ensembl ID		ENSG00000244752	ENSG00000160202
Uniprot IDs		P43320 R4UMM2	A0A8C8KJZ9 P02489
PDB IDs		1YTQ 7K7U	6T1R
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Protein Refolding System Process Nervous System Process Tubulin Complex Assembly Response To Heat Camera-type Eye Development Contractile Muscle Fiber Unfolded Protein Binding Eye Development Response To Temperature Stimulus Apoptotic Process Involved In Morphogenesis Sensory Organ Development Apoptotic Process Involved In Development Protein Folding Negative Regulation Of Intracellular Transport Developmental Process Homotypic Cell-cell Adhesion Negative Regulation Of Protein Kinase C Signaling Identical Protein Binding Response To Hydrogen Peroxide Protein Kinase C Inhibitor Activity Ventral Spinal Cord Interneuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Z Disc Regulation Of Protein Kinase C Signaling Response To Reactive Oxygen Species Gap Junction-mediated Intercellular Transport Structural Molecule Activity Lens Fiber Cell Morphogenesis Cardiac Myofibril Positive Regulation Of Anoikis Spinal Cord Motor Neuron Cell Fate Specification Regulation Of Apoptotic Process Animal Organ Development Maintenance Of Lens Transparency Actin Filament Bundle Anterograde Axonal Protein Transport Regulation Of Programmed Cell Death Intercellular Transport Spinal Cord Association Neuron Differentiation	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye
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