ZRANB2 and YY1

Number of citations of the paper that reports this interaction (PubMedID 11448987)
58

Data Source:
HPRD (in vivo)

		ZRANB2	YY1
Description		zinc finger RANBP2-type containing 2	YY1 transcription factor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromatin Silencing Complex Nuclear Matrix Ino80 Complex PcG Protein Complex
	Molecular Function	Lipopolysaccharide Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding SMAD Binding Metal Ion Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	RNA Processing MRNA Processing RNA Splicing	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Localization DNA Damage Response Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Hemopoiesis Cell Differentiation B Cell Differentiation Negative Regulation Of Interferon-beta Production Regulation Of Chromosome Organization Cellular Response To UV Response To Prostaglandin F Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Camera-type Eye Morphogenesis Chromosome Organization Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Interleukin-1 Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of MiRNA Transcription Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690) Verbal declarative memory ( 25648963)	Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Pulse pressure ( 30224653)
Interacting Genes		17 interacting genes: AKAP17A CEBPA CSNK2A1 EP300 KIF20A LRRK2 OGT SMN1 SNRNP70 SREK1 SRPK1 SRPK2 SRSF2 TRA2B U2AF1 UBC YY1	98 interacting genes: ALOXE3 APP ATF2 ATF6 ATF7 AURKA BAP1 BRCA1 CDKN2A CEBPA CEP76 CREB1 CREBBP CRKL CYSRT1 DNMT3L E2F2 E2F3 EED EP300 ESM1 FHL2 FKBP1A FKBP3 FOXP1 FOXP2 FOXP4 GFER GMCL1 GRN GTF2I HDAC2 HDAC3 HMGB1 HNF1B HOXA11 IL10 ITCH KAT2B KRTAP1-3 KRTAP1-5 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP4-5 KRTAP5-6 KRTAP9-3 KRTAP9-8 MDFI MED20 MTA2 MYC NEDD4L NFIC NFIX NFKB1 NOTCH1 NPM1 NR1H2 PIAS4 PLEKHF2 PPIA PSMD9 RAF1 RYBP SAP30 SF3A2 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 TRIM42 TWIST1 UBE2I UHRF2 USP21 USP7 VWC2 XAGE1A XAGE1B YAF2 ZNF232 ZNF85 ZRANB2
Entrez ID		9406	7528
HPRD ID		09185	02482
Ensembl ID		ENSG00000132485	ENSG00000100811
Uniprot IDs		O95218	P25490
PDB IDs		1N0Z 2K1P 3G9Y	1UBD 1ZNM 4C5I
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Metabolic Process MRNA Processing RNA Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Macromolecule Metabolic Process RNA Binding Regulation Of RNA Splicing RNA Processing Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing Spliceosomal Complex Nucleus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Nucleic Acid Binding Spliceosomal Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process RNA Splicing, Via Transesterification Reactions STAT Family Protein Binding Regulation Of RNA Metabolic Process Chromatin DNA Binding Negative Regulation Of Autophagy Regulation Of Nucleobase-containing Compound Metabolic Process Sin3-type Complex Negative Regulation Of Protein Catabolic Process Regulation Of Gene Expression Histone Acetyltransferase Complex Nuclear Matrix Protein Kinase A Binding Regulation Of Macromolecule Biosynthetic Process PcG Protein Complex Protein Serine Kinase Activity Negative Regulation Of Proteolysis Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macrophage Activation Regulation Of Primary Metabolic Process Positive Regulation Of Viral Genome Replication Regulation Of Autophagy Regulation Of Proteolysis Protein Serine/threonine Kinase Activity Hemopoiesis Positive Regulation Of Proteolysis	Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intermediate Filament Chromatin Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Keratin Filament Epigenetic Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription By RNA Polymerase II Negative Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Identical Protein Binding Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Transcription Regulator Complex Chromatin Remodeling
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