SAFB and MIR98

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		SAFB	MIR98
Description		scaffold attachment factor B	microRNA 98
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Midbody	Extracellular Space RISC Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding RNA Binding Protein Binding Sequence-specific DNA Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Estrogen Receptor Signaling Pathway Regulation Of MRNA Processing Regulation Of Androgen Receptor Signaling Pathway	Negative Regulation Of Cytokine Production Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Extracellular Matrix Assembly Cellular Response To Amyloid-beta Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Endothelial Cell Proliferation
Pathways		SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	Bipolar disorder ( 31043756)
Interacting Genes		30 interacting genes: ABHD16A CDC37 CEBPA CHD1 CHD3 CLK1 CSNK2A1 CYCS ESR1 HNRNPA1 HNRNPD HNRNPK IL7R LINC00941 MIR199A1 MIR363 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7D NCOR1 POLR2A SAFB2 SREK1 SRPK1 SRPK2 SRSF9 SUMO2 TAF15 TJP2	77 interacting genes: ADARB1 APOBEC3B ATXN2L C1QBP CPSF1 DARS1 DDX1 DDX21 DDX3X DDX3Y DHX36 EDC4 EIF2AK2 EPRS1 ESRP1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUFIP2 PDCD11 PLOD1 PTBP1 PTBP3 PUM1 QARS1 RARS1 RBM12B RBM14 RTCB SAFB SF3B1 SF3B2 SF3B3 SFPQ STRBP SYNCRIP TAF15 TRA2A TRA2B TRIM25 TUT4 U2SURP UPF1 YBX1 YBX3 ZFR ZNF346
Entrez ID		6294	407054
HPRD ID		04205
Ensembl ID		ENSG00000160633	ENSG00000271886
Uniprot IDs		B7Z2F6 B7ZLP5 Q15424
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulatory NcRNA-mediated Gene Silencing Regulation Of Metabolic Process Regulation Of RNA Splicing MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of MRNA Processing Post-transcriptional Gene Silencing Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RISC Complex Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression RNA Splicing MRNA Base-pairing Post-transcriptional Repressor Activity Nucleoplasm Negative Regulation Of Metabolic Process Nucleic Acid Binding RNA Binding MRNA Metabolic Process Chromatin RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Interleukin-6-mediated Signaling Pathway Protein Domain Specific Binding Positive Regulation Of Catabolic Process MRNA 3'-UTR Binding Chromatin Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Processing DNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of MRNA Stability Nucleus Nucleic Acid Metabolic Process ATP-dependent Chromatin Remodeler Activity	RNA Binding Nucleic Acid Binding RNA Metabolic Process RNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Binding MRNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Ribonucleoprotein Complex Nucleus Cytoplasmic Stress Granule Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Post-transcriptional Regulation Of Gene Expression Nucleoplasm Negative Regulation Of MRNA Metabolic Process Spliceosomal Complex Catalytic Step 2 Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of Gene Expression MiRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Negative Regulation Of RNA Catabolic Process Regulation Of RNA Stability MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of MRNA Stability MRNA Stabilization Regulation Of Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity P-body Nucleolus TRNA Aminoacylation CRD-mediated MRNA Stabilization MRNA 5'-UTR Binding TRNA Metabolic Process
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