SAFB and TJP2

Number of citations of the paper that reports this interaction (PubMedID 12403786)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SAFB	TJP2
Description		scaffold attachment factor B	tight junction protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Midbody	Nucleus Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Cell-cell Contact Zone Tight Junction Anchoring Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding RNA Binding Protein Binding Sequence-specific DNA Binding	GMP Kinase Activity Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Cadherin Binding Cell Adhesion Molecule Binding Protein Tyrosine Kinase Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Estrogen Receptor Signaling Pathway Regulation Of MRNA Processing Regulation Of Androgen Receptor Signaling Pathway	Homotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Cell-cell Junction Organization GMP Metabolic Process GDP Metabolic Process Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Protein Localization To Cell-cell Junction Positive Regulation Of Blood-brain Barrier Permeability
Pathways		SUMOylation of transcription cofactors	Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	Macular thickness ( 30535121) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 23396134 32231278) Renal sinus fat ( 22044751) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		30 interacting genes: ABHD16A CDC37 CEBPA CHD1 CHD3 CLK1 CSNK2A1 CYCS ESR1 HNRNPA1 HNRNPD HNRNPK IL7R LINC00941 MIR199A1 MIR363 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7D NCOR1 POLR2A SAFB2 SREK1 SRPK1 SRPK2 SRSF9 SUMO2 TAF15 TJP2	16 interacting genes: CDK6 CGN CLDN1 CLDN2 CLK1 CTNNA1 EPB41 HGS HSPB1 SAFB SCRIB SH3KBP1 TJP1 YWHAB YWHAG YWHAZ
Entrez ID		6294	9414
HPRD ID		04205	06369
Ensembl ID		ENSG00000160633	ENSG00000119139
Uniprot IDs		B7Z2F6 B7ZLP5 Q15424	A0A3B3IU51 B7Z2R3 B7Z954 Q9UDY2
PDB IDs			2OSG 3E17
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulatory NcRNA-mediated Gene Silencing Regulation Of Metabolic Process Regulation Of RNA Splicing MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of MRNA Processing Post-transcriptional Gene Silencing Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RISC Complex Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression RNA Splicing MRNA Base-pairing Post-transcriptional Repressor Activity Nucleoplasm Negative Regulation Of Metabolic Process Nucleic Acid Binding RNA Binding MRNA Metabolic Process Chromatin RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Interleukin-6-mediated Signaling Pathway Protein Domain Specific Binding Positive Regulation Of Catabolic Process MRNA 3'-UTR Binding Chromatin Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Processing DNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of MRNA Stability Nucleus Nucleic Acid Metabolic Process ATP-dependent Chromatin Remodeler Activity	Cell Junction Anchoring Junction Cadherin Binding Cell-cell Junction Focal Adhesion Protein Kinase C Inhibitor Activity Cell-cell Adhesion Cell-cell Junction Assembly Tight Junction Bicellular Tight Junction Protein Localization To Adherens Junction Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Cell-cell Junction Organization Structural Molecule Activity Protein Targeting Protein Domain Specific Binding Regulation Of Multicellular Organismal Process Basolateral Plasma Membrane Regulation Of Intestinal Absorption Protein Localization To Cell Junction Intracellular Protein Localization Cell Adhesion Cell Junction Assembly Establishment Of Endothelial Intestinal Barrier Regulation Of Developmental Process Regulation Of Translational Initiation Protein Localization To Cell-cell Junction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Bicellular Tight Junction Assembly Epithelial Cell Development Regulation Of Protein Localization To Nucleus Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Phosphoprotein Binding Identical Protein Binding Anatomical Structure Homeostasis Tissue Homeostasis Adherens Junction Establishment Of Protein Localization Endothelial Cell Development Cell Junction Organization Bicellular Tight Junction Assembly Cyclin D2-CDK6 Complex Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Binding Negative Regulation Of Translational Initiation Xenobiotic Transport Across Blood-nerve Barrier Cellular Response To Glucose Starvation
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