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CRK and BCAR1
Number of citations of the paper that reports this interaction (PubMedID
22974441
)
124
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, unspecified method)
HPRD
(in vivo)
CRK
BCAR1
Description
CRK proto-oncogene, adaptor protein
BCAR1 scaffold protein, Cas family member
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Actin Cytoskeleton
Membrane
Neuromuscular Junction
Protein-containing Complex
Extracellular Exosome
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Membrane
Lamellipodium
Axon
Cell Projection
Anchoring Junction
Molecular Function
Phosphotyrosine Residue Binding
Signaling Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Cytoskeletal Protein Binding
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Domain Specific Binding
Signaling Receptor Complex Adaptor Activity
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Phosphorylated Amino Acid Binding
Ephrin Receptor Binding
Scaffold Protein Binding
Protein Tyrosine Kinase Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Biological Process
Neuron Migration
Response To Yeast
Regulation Of Leukocyte Migration
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Signal Transduction
Positive Regulation Of Smooth Muscle Cell Migration
Dendrite Development
Cell Migration
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Positive Regulation Of Cell Growth
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Rac Protein Signal Transduction
Positive Regulation Of Rac Protein Signal Transduction
Helper T Cell Diapedesis
Response To Hepatocyte Growth Factor
Reelin-mediated Signaling Pathway
Response To Hydrogen Peroxide
Regulation Of GTPase Activity
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of JNK Cascade
Ephrin Receptor Signaling Pathway
Regulation Of Dendrite Development
Cell Chemotaxis
Regulation Of Wound Healing
Negative Regulation Of Wound Healing
Response To Cholecystokinin
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To Nitric Oxide
Protein Localization To Membrane
Postsynaptic Specialization Assembly
Cerebellar Neuron Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Response To Peptide
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Endothelin
Regulation Of Cell Motility
Negative Regulation Of Cell Motility
Regulation Of T Cell Migration
Regulation Of Cell Growth
Actin Filament Organization
Cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Insulin Receptor Signaling Pathway
Positive Regulation Of Endothelial Cell Migration
Cell Migration
Positive Regulation Of Cell Migration
Cellular Response To Hepatocyte Growth Factor Stimulus
Regulation Of Apoptotic Process
Platelet-derived Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Cell Division
Cell Chemotaxis
Endothelin Receptor Signaling Pathway
Pathways
ARMS-mediated activation
ARMS-mediated activation
Downstream signal transduction
Regulation of actin dynamics for phagocytic cup formation
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
MET receptor recycling
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
Downstream signal transduction
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS
Atrial fibrillation (
30061737
)
Granulocyte count (
27863252
)
Intraocular pressure (
30591961
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
)
Pulse pressure (
27841878
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systolic blood pressure (
27841878
28135244
30578418
)
Advanced age-related macular degeneration (
26691988
)
Alcoholic chronic pancreatitis (
28754779
)
Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) (
30940143
)
Coronary artery disease (
33020668
)
Crohn's disease (time to surgery) (
23665963
)
Intracranial aneurysm (
33199917
)
Myocardial infarction (
33532862
)
Offspring birth weight (
31043758
)
Pancreatic cancer (
25086665
29422604
)
Type 1 diabetes (
25751624
)
Type 2 diabetes (
22885922
29358691
30297969
)
Interacting Genes
189 interacting genes:
ABL1
ABL2
ADGRL3
ANKZF1
ANLN
AR
ARHGAP17
ARHGAP32
ASAP1
ASAP3
ASCL4
ATF3
ATXN1
AVIL
BATF3
BCAR1
BCR
BEX5
BICRA
BUB1
C1orf94
C4orf17
C6orf141
CBL
CBLC
CHTF18
CLNK
CNDP2
CORO6
CRKL
DAB1
DOCK1
DOCK3
DOCK5
DOK1
DOK2
DOK3
DOK4
DOK7
DPPA4
EFS
EGFR
ELK1
ELK3
EPHA3
EPHB2
EPHB3
EPHB6
EPS15
EPYC
ERBB2
ERBB3
ERBB4
ESD
EYA3
FAM110B
FASLG
FER
FGFR1
FLACC1
FLT1
FRS2
FSTL1
FYN
GAB1
GABPB2
GAREM1
GRB2
HABP4
HSH2D
IFT140
IGF1R
IKZF3
INO80E
INPP5D
INSR
IQCE
IRS1
IRS2
IRS4
ISL1
IVL
KCNJ3
KCTD13
KCTD17
KDR
KHDRBS1
KIT
KLF15
KLHL20
KMT2E
LASP1
LHX8
LNX2
MAGEC3
MAP4K1
MAP4K5
MAPK4
MAPK8
MET
MICAL1
MNDA
MPG
MYLIP
MYOZ2
NCK1
NEDD9
NPM3
NTRK1
NUFIP2
OFCC1
PAFAH1B2
PDGFRA
PDGFRB
PHC2
PIK3R1
PIK3R2
PIK3R3
PLSCR1
POT1
PPFIBP2
PPP1CA
PRKACA
PRR14
PRRC2B
PRRG2
PSMC1
PSMC6
PTK2
PTK2B
PTPN1
PTPN22
PTPN4
PTPRH
PTTG1
PXN
RAB2B
RAD54L2
RAPGEF1
REPS1
RET
RTCB
RYBP
SASH1
SAXO1
SEMA4D
SEPTIN6
SETD9
SH2B1
SH2D2A
SH3BP1
SHB
SHC1
SOCS1
SOCS6
SOS1
SPATA31F1
SPEN
SPRR2A
STAT4
STAT5A
STAT5B
STRN4
SYN1
SYNGAP1
TASOR2
TCAP
TCOF1
TDG
TERF2IP
TM4SF19
TP53BP2
TRIM25
TUBA1C
TWIST2
TXK
USP53
VAC14
VAV1
VPS37B
WASF1
WDR83
WEE1
XPO1
ZAP70
ZKSCAN5
ZKSCAN7
ZNF557
ZNF804A
65 interacting genes:
ABL1
AJUBA
ANKS1A
ARHGAP32
BMX
CASP3
CD2AP
COPB1
CRK
CRKL
CSPG4
DOCK1
DOK7
E2F2
EEIG1
EFS
ESR1
FAM90A1
FES
FXYD6
FYB1
FYN
GLIS2
GRB2
GSN
HCK
HSPA5
INPPL1
LCK
LYN
MMP14
NCK1
NCK2
NEDD9
NPHP1
PIK3R1
PKD1
PLPP3
PPP1R15A
PRAM1
PTEN
PTK2
PTK2B
PTPN1
PTPN12
PTPRA
PTPRF
PTPRH
PXN
RAN
RAPGEF1
SH2D3A
SH2D3C
SH3KBP1
SRC
SRCIN1
TNS3
TRIP6
TUBA4A
UHRF2
USP2
VCL
VPS11
YES1
YWHAZ
Entrez ID
1398
9564
HPRD ID
01267
04248
Ensembl ID
ENSG00000167193
ENSG00000050820
Uniprot IDs
A0A0S2Z3K9
A0A0S2Z3Q4
L7RT18
P46108
B3KWE2
P56945
PDB IDs
1JU5
2DVJ
2EYV
2EYW
2EYX
2EYY
2EYZ
2MS4
5UL6
6ATV
1WYX
3T6G
5O2M
5O2P
5O2Q
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
SH3 Domain Binding
Peptidyl-tyrosine Phosphorylation
Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Kinase Activity
Cell Migration
Phosphotyrosine Residue Binding
Regulation Of Intracellular Signal Transduction
Protein Binding
Cell Motility
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Kinase Activity
Insulin Receptor Signaling Pathway
Cytosol
Protein Phosphorylation
Response To Growth Factor
Positive Regulation Of Cellular Component Organization
Regulation Of MAPK Cascade
Positive Regulation Of Cell Migration
ERBB Signaling Pathway
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Motility
Cytoplasm
Protein Autophosphorylation
Regulation Of Cellular Component Organization
Positive Regulation Of Signal Transduction
Positive Regulation Of Locomotion
Regulation Of Signaling
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Positive Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signaling Cassette
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Cell Migration
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Cell Motility
Regulation Of Cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Focal Adhesion
Non-membrane Spanning Protein Tyrosine Kinase Activity
Phosphotyrosine Residue Binding
Regulation Of Cell Adhesion
Cell Migration
Ephrin Receptor Binding
Cell Surface Receptor Signaling Pathway
Signal Transduction
Cell Motility
Regulation Of Cell-substrate Adhesion
Ephrin Receptor Signaling Pathway
Anchoring Junction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Signal Complex Assembly
Regulation Of Immune System Process
Integrin-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Immune System Process
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Protein Tyrosine Kinase Activity
Fc Receptor Mediated Stimulatory Signaling Pathway
Plasma Membrane
Immune Response-activating Signaling Pathway
Regulation Of Cell Motility
Antigen Receptor-mediated Signaling Pathway
SH3 Domain Binding
Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Regulation Of Locomotion
Regulation Of Intracellular Signal Transduction
Immune Response-regulating Signaling Pathway
Regulation Of Cell Migration
Fc Receptor Signaling Pathway
Activation Of Immune Response
Regulation Of Cell-matrix Adhesion
Intracellular Signal Transduction
Cytosol
Regulation Of Cytoskeleton Organization
Cytoplasm
Regulation Of Signal Transduction
Cell Adhesion
Cell-cell Junction
Regulation Of Cell Junction Assembly
Plasma Membrane Bounded Cell Projection Organization
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Cell Adhesion
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Tagcloud (Difference)
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Tagcloud (Intersection)
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