CRK and STAT5A

Number of citations of the paper that reports this interaction (PMID 11097834)
2

Data Source:
HPRD (in vitro, in vivo)

		CRK	STAT5A
Gene Name		v-crk avian sarcoma virus CT10 oncogene homolog	signal transducer and activator of transcription 5A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Extracellular Vesicular Exosome	Nucleoplasm Cytosol
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding SH2 Domain Binding Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding
	Biological Process	Activation Of MAPKK Activity Regulation Of Transcription From RNA Polymerase II Promoter Blood Coagulation Insulin Receptor Signaling Pathway Platelet Activation Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Rac Protein Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway	Allantoin Metabolic Process Luteinization Natural Killer Cell Differentiation Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process JAK-STAT Cascade Female Pregnancy Lactation Peptidyl-tyrosine Phosphorylation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Positive Regulation Of Natural Killer Cell Differentiation Negative Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Positive Regulation Of Mast Cell Differentiation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Mammary Gland Epithelium Development Positive Regulation Of Mast Cell Proliferation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Pathways		Signalling to ERKs Prolonged ERK activation events Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway Regulation of signaling by CBL Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Signaling by Insulin receptor Innate Immune System Signaling by PDGF Signalling by NGF Insulin receptor signalling cascade p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane ARMS-mediated activation Signaling by Interleukins Signal attenuation Signaling by VEGF Downstream signal transduction Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		84 interactors: ABL1 ABL2 ARHGAP17 ARHGAP32 ASAP1 ATXN1 AVIL BCAR1 BCR BUB1 CBL CBLC CRKL DAB1 DOCK1 DOCK3 DOK1 DOK4 DPPA4 EFS EGFR EPHA3 EPHB2 EPHB3 EPHB6 EPS15 ERBB2 ERBB3 ERBB4 FAM154A FASLG FGFR1 FLT1 FRS2 FYN GAB1 GRB2 IGF1R INSR IRS1 IRS2 IRS4 KDR KHDRBS1 KIT MAP4K1 MAP4K5 MAPK4 MAPK8 MICAL1 NCK1 NEDD9 NTRK1 PDGFRA PDGFRB PIK3R1 PLSCR1 POT1 PPFIBP2 PPP1CA PSMC6 PTK2 PTK2B PTPN1 PTPN4 PXN RAPGEF1 REPS1 RET SH3BP1 SHB SHC1 SOCS1 SOS1 SPRR2A STAT5A STAT5B SYN1 TERF2IP VAV1 WASF1 WEE1 XPO1 ZAP70	72 interactors: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CENPJ CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK LEF1 MAGEA12 MAPK1 MAPK3 MRPS6 NARF NCOR2 NLK NMI NR3C1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TSLP TXNDC11 UGT2B4 WASH2P ZNF596
Entrez ID		1398	6776
HPRD ID		01267	03301
Ensembl ID		ENSG00000167193	ENSG00000126561
Uniprot IDs		L7RT18 P46108	A8K6I5 K7EK35 P42229 Q59GY7
PDB IDs		1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling ERBB Signaling Pathway Regulation Of Signal Transduction Signaling Positive Regulation Of Signal Transduction Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway Response To Growth Factor Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Catalytic Activity Protein Autophosphorylation Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Response To Stimulus Cellular Response To Organonitrogen Compound Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Organic Substance Phosphatidylinositol-mediated Signaling Regulation Of Immune Response Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Peptidyl-amino Acid Modification Immune Response-regulating Signaling Pathway Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of MAPK Cascade Immune System Process Positive Regulation Of Transferase Activity Phosphorylation Cellular Response To Peptide Positive Regulation Of MAPK Cascade Fc-epsilon Receptor Signaling Pathway Innate Immune Response	Cellular Response To Organic Substance Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Hormone Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Protein Autophosphorylation Cellular Response To Stimulus Immune Response Signal Transduction Immune System Process Cellular Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Signaling Cell Communication Cellular Response To Cytokine Stimulus Regulation Of Immune Response Defense Response Response To Cytokine Positive Regulation Of Cellular Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Peptidyl-amino Acid Modification Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Cellular Response To Growth Hormone Stimulus Innate Immune Response Cellular Response To Peptide Response To Organonitrogen Compound Regulation Of Immune System Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Proliferation Organ Development Response To Growth Factor Cytokine-mediated Signaling Pathway JAK-STAT Cascade Regulation Of MAPK Cascade Response To Peptide Hormone Neurotrophin TRK Receptor Signaling Pathway Response To Peptide Fc Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity Response To Growth Hormone Positive Regulation Of Metabolic Process Neurotrophin Signaling Pathway Anatomical Structure Development
Tagcloud ?		abundantly adhesions arises associating carboxy cas conferring connect coordinating dim1p efs encompassed encompasses fyn hef1 identifies interactor localize multidomain oncoproteins p105 p115 p130 p55 sh3 sin spindle sum unexpectedly	advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely
Tagcloud (Difference) ?		abundantly adhesions arises associating carboxy cas conferring connect coordinating dim1p efs encompassed encompasses fyn hef1 identifies interactor localize multidomain oncoproteins p105 p115 p130 p55 sh3 sin spindle sum unexpectedly	advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely
Tagcloud (Intersection) ?