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BCAR1 and ARHGAP32
Number of citations of the paper that reports this interaction (PubMedID
12446789
)
62
Data Source:
HPRD
(in vivo, in vitro)
BCAR1
ARHGAP32
Description
BCAR1 scaffold protein, Cas family member
Rho GTPase activating protein 32
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Membrane
Lamellipodium
Axon
Cell Projection
Anchoring Junction
Golgi Membrane
Fibrillar Center
Nucleoplasm
Cytoplasm
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Cell Cortex
Endosome Membrane
Postsynaptic Density
Actin Cytoskeleton
Membrane
Cell Projection
Dendritic Spine
Synapse
Molecular Function
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
GTPase Activator Activity
Protein Binding
Phosphatidylinositol Binding
Phosphatidylinositol Phosphate Binding
Biological Process
Regulation Of Cell Growth
Actin Filament Organization
Cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Insulin Receptor Signaling Pathway
Positive Regulation Of Endothelial Cell Migration
Cell Migration
Positive Regulation Of Cell Migration
Cellular Response To Hepatocyte Growth Factor Stimulus
Regulation Of Apoptotic Process
Platelet-derived Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Cell Division
Cell Chemotaxis
Endothelin Receptor Signaling Pathway
Signal Transduction
Small GTPase-mediated Signal Transduction
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
Downstream signal transduction
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOQ GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RAC3 GTPase cycle
RHOF GTPase cycle
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases
GWAS
Advanced age-related macular degeneration (
26691988
)
Alcoholic chronic pancreatitis (
28754779
)
Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) (
30940143
)
Coronary artery disease (
33020668
)
Crohn's disease (time to surgery) (
23665963
)
Intracranial aneurysm (
33199917
)
Myocardial infarction (
33532862
)
Offspring birth weight (
31043758
)
Pancreatic cancer (
25086665
29422604
)
Type 1 diabetes (
25751624
)
Type 2 diabetes (
22885922
29358691
30297969
)
Intracranial aneurysm (
30823506
)
Iris color (L* coordinate) (
29109912
)
Macular thickness (
30535121
)
Metabolite levels (5-HIAA) (
23319000
)
Refractive error (
32231278
)
Interacting Genes
65 interacting genes:
ABL1
AJUBA
ANKS1A
ARHGAP32
BMX
CASP3
CD2AP
COPB1
CRK
CRKL
CSPG4
DOCK1
DOK7
E2F2
EEIG1
EFS
ESR1
FAM90A1
FES
FXYD6
FYB1
FYN
GLIS2
GRB2
GSN
HCK
HSPA5
INPPL1
LCK
LYN
MMP14
NCK1
NCK2
NEDD9
NPHP1
PIK3R1
PKD1
PLPP3
PPP1R15A
PRAM1
PTEN
PTK2
PTK2B
PTPN1
PTPN12
PTPRA
PTPRF
PTPRH
PXN
RAN
RAPGEF1
SH2D3A
SH2D3C
SH3KBP1
SRC
SRCIN1
TNS3
TRIP6
TUBA4A
UHRF2
USP2
VCL
VPS11
YES1
YWHAZ
33 interacting genes:
ABI2
ATXN1
BCAR1
CAMK2N2
CDC42
CDH1
CDH2
CRK
CRKL
CTNNB1
DLG4
DZIP3
FYN
GAB1
GAB2
GRAP
GRB2
GRIN2A
GRIN2B
LHX2
MDFI
MEGF10
NCK1
NCK2
NPHP1
NTRK1
PIK3R1
PLCG1
RAC1
RHOA
SHC3
SRC
TLE5
Entrez ID
9564
9743
HPRD ID
04248
12257
Ensembl ID
ENSG00000050820
ENSG00000134909
Uniprot IDs
B3KWE2
P56945
A0A804HK06
A7KAX9
PDB IDs
1WYX
3T6G
5O2M
5O2P
5O2Q
3IUG
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Focal Adhesion
Non-membrane Spanning Protein Tyrosine Kinase Activity
Phosphotyrosine Residue Binding
Regulation Of Cell Adhesion
Cell Migration
Ephrin Receptor Binding
Cell Surface Receptor Signaling Pathway
Signal Transduction
Cell Motility
Regulation Of Cell-substrate Adhesion
Ephrin Receptor Signaling Pathway
Anchoring Junction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Signal Complex Assembly
Regulation Of Immune System Process
Integrin-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Immune System Process
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Protein Tyrosine Kinase Activity
Fc Receptor Mediated Stimulatory Signaling Pathway
Plasma Membrane
Immune Response-activating Signaling Pathway
Regulation Of Cell Motility
Antigen Receptor-mediated Signaling Pathway
SH3 Domain Binding
Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Regulation Of Locomotion
Regulation Of Intracellular Signal Transduction
Immune Response-regulating Signaling Pathway
Regulation Of Cell Migration
Fc Receptor Signaling Pathway
Activation Of Immune Response
Regulation Of Cell-matrix Adhesion
Intracellular Signal Transduction
Cytosol
Regulation Of Cytoskeleton Organization
Cytoplasm
Regulation Of Signal Transduction
Cell Adhesion
Cell-cell Junction
Regulation Of Cell Junction Assembly
Plasma Membrane Bounded Cell Projection Organization
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Migration
Cell Surface Receptor Signaling Pathway
Cell Motility
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Phosphotyrosine Residue Binding
Regulation Of Cell Projection Organization
Positive Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Signal Transduction
Cell-cell Junction
Ephrin Receptor Signaling Pathway
Regulation Of Signal Transduction
Developmental Process
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Cellular Component Organization
Regulation Of MAPK Cascade
Positive Regulation Of Cellular Component Biogenesis
Ephrin Receptor Binding
Lamellipodium
Intracellular Signaling Cassette
Intracellular Signal Transduction
Regulation Of Synapse Organization
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Lamellipodium Organization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Intracellular Signal Transduction
Protein Kinase Binding
Signaling Adaptor Activity
Neuron Migration
Regulation Of Cell Migration
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Cell Projection Organization
Establishment Or Maintenance Of Cell Polarity
Regulation Of Cell Motility
Regulation Of Intracellular Signal Transduction
Actin Filament Organization
Regulation Of Actin Filament Organization
Positive Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Filament-based Process
Regulation Of Locomotion
Cell-cell Junction Organization
Regulation Of Lamellipodium Organization
Cell Projection Organization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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