BCAR1 and CSPG4

Number of citations of the paper that reports this interaction (PMID 10587647)
45

Data Source:
HPRD (in vivo, in vitro)

		BCAR1	CSPG4
Gene Name		breast cancer anti-estrogen resistance 1	chondroitin sulfate proteoglycan 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium	Extracellular Region Golgi Lumen Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Apical Plasma Membrane Lamellipodium Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding	Signal Transducer Activity Protein Kinase Binding
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis	Activation Of MAPK Activity Angiogenesis Carbohydrate Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Proliferation Glial Cell Migration Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Intracellular Signal Transduction Small Molecule Metabolic Process Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Pathways		Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ	9 interactors: ATF7IP BCAR1 C1QA CDC42 GRIP1 GRIP2 MPDZ PTK2 TNK2
Entrez ID		9564	1464
HPRD ID		04248	03105
Ensembl ID		ENSG00000050820	ENSG00000173546
Uniprot IDs		B2RBL9 B3KWE2 F5H855 P56945	Q6UVK1
PDB IDs		1WYX 3T6G
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling	Vascular Endothelial Growth Factor Receptor Signaling Pathway Establishment Of Nucleus Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nucleus Localization Peptidyl-tyrosine Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Phosphatidylinositol 3-kinase Activity Cell Migration Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Lipid Kinase Activity Cell Motility Positive Regulation Of Immune System Process Cell-cell Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Blood Coagulation Hemostasis Immune System Process Immune Response-regulating Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Positive Regulation Of Hair Follicle Cell Proliferation Locomotion Immune Response Regulation Of Immune System Process Signaling Integrin-mediated Signaling Pathway Defense Response Cell Communication Regulation Of Body Fluid Levels Actin Filament Branching Submandibular Salivary Gland Formation Wound Healing Chemotaxis Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial Cell Migration Movement Of Cell Or Subcellular Component Netrin-activated Signaling Pathway Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Tagcloud ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	avenues breakthrough checkpoint constituted counteract ctla4 employ helped immunomodulatory immunotherapies immunotherapy interface l1 lethal mcsp melanoma modalities perhaps promise recognised recognising redirect restrict spread standing subsets tumour unexplored vasculature
Tagcloud (Difference) ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	avenues breakthrough checkpoint constituted counteract ctla4 employ helped immunomodulatory immunotherapies immunotherapy interface l1 lethal mcsp melanoma modalities perhaps promise recognised recognising redirect restrict spread standing subsets tumour unexplored vasculature
Tagcloud (Intersection) ?