Wiki-Pi
About
Search
People
Updates
Search
BCAR1 and HSPA5
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
BCAR1
HSPA5
Description
BCAR1 scaffold protein, Cas family member
heat shock protein family A (Hsp70) member 5
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Membrane
Lamellipodium
Axon
Cell Projection
Anchoring Junction
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Cell Surface
Membrane
Midbody
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Nucleotide Binding
Calcium Ion Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Enzyme Binding
Protein Domain Specific Binding
Protein Serine/threonine Kinase Inhibitor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Protein-folding Chaperone Binding
Misfolded Protein Binding
ATP-dependent Protein Folding Chaperone
Biological Process
Regulation Of Cell Growth
Actin Filament Organization
Cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Insulin Receptor Signaling Pathway
Positive Regulation Of Endothelial Cell Migration
Cell Migration
Positive Regulation Of Cell Migration
Cellular Response To Hepatocyte Growth Factor Stimulus
Regulation Of Apoptotic Process
Platelet-derived Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Cell Division
Cell Chemotaxis
Endothelin Receptor Signaling Pathway
Translational Initiation
Protein Folding
ER Overload Response
Cerebellum Structural Organization
Cerebellar Purkinje Cell Layer Development
Substantia Nigra Development
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Post-translational Protein Targeting To Membrane, Translocation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Ubiquitination
Protein Folding In Endoplasmic Reticulum
Response To Endoplasmic Reticulum Stress
Maintenance Of Protein Localization In Endoplasmic Reticulum
IRE1-mediated Unfolded Protein Response
PERK-mediated Unfolded Protein Response
ERAD Pathway
Protein Refolding
Cellular Response To Glucose Starvation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Folding In Endoplasmic Reticulum
Cellular Response To Interleukin-4
Regulation Of ATF6-mediated Unfolded Protein Response
Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways
Downstream signal transduction
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Platelet degranulation
Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
ATF6B (ATF6-beta) activates chaperones
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Modulation of host responses by IFN-stimulated genes
Drugs
Antihemophilic factor, human recombinant
Acetylsalicylic acid
Copper
Lonoctocog alfa
Moroctocog alfa
Diseases
GWAS
Advanced age-related macular degeneration (
26691988
)
Alcoholic chronic pancreatitis (
28754779
)
Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) (
30940143
)
Coronary artery disease (
33020668
)
Crohn's disease (time to surgery) (
23665963
)
Intracranial aneurysm (
33199917
)
Myocardial infarction (
33532862
)
Offspring birth weight (
31043758
)
Pancreatic cancer (
25086665
29422604
)
Type 1 diabetes (
25751624
)
Type 2 diabetes (
22885922
29358691
30297969
)
Refractive error (
32231278
)
Smoking initiation (
33082346
)
Interacting Genes
65 interacting genes:
ABL1
AJUBA
ANKS1A
ARHGAP32
BMX
CASP3
CD2AP
COPB1
CRK
CRKL
CSPG4
DOCK1
DOK7
E2F2
EEIG1
EFS
ESR1
FAM90A1
FES
FXYD6
FYB1
FYN
GLIS2
GRB2
GSN
HCK
HSPA5
INPPL1
LCK
LYN
MMP14
NCK1
NCK2
NEDD9
NPHP1
PIK3R1
PKD1
PLPP3
PPP1R15A
PRAM1
PTEN
PTK2
PTK2B
PTPN1
PTPN12
PTPRA
PTPRF
PTPRH
PXN
RAN
RAPGEF1
SH2D3A
SH2D3C
SH3KBP1
SRC
SRCIN1
TNS3
TRIP6
TUBA4A
UHRF2
USP2
VCL
VPS11
YES1
YWHAZ
77 interacting genes:
A2M
AGO4
APC
APOB
BAG3
BCAR1
CASP7
CDK7
CPT1A
DDX24
DNAJC1
DNAJC10
DPH1
DPYSL5
EIF2AK3
ERBB2
ERCC6
ERN1
ERP29
F8
FCHSD2
FNDC3B
GRIA1
HLA-C
HMGB1
HSPBP1
HTR3A
IGHM
KRT14
KRT18
KRT8
LCT
LDLR
LINC01554
MATK
METTL21A
MTNR1A
MTNR1B
NDRG1
NEDD4L
NRIP1
OTUD3
PARK7
PAWR
PCSK7
PRDM14
PRNP
PSME3
PTPN11
PTPRF
RIPK4
RNF114
RNF26
RPN1
SEC61A1
SEC63
SERPINB5
SH3BP4
SIL1
SIRPA
SQSTM1
SREBF2
STMN1
SUMO2
SUMO4
TCERG1
TG
TMEM132A
TMEM62
TRA
TSHR
UBE3A
UBQLN4
VHL
VWF
XAF1
YWHAB
Entrez ID
9564
3309
HPRD ID
04248
00682
Ensembl ID
ENSG00000050820
ENSG00000044574
Uniprot IDs
B3KWE2
P56945
P11021
V9HWB4
PDB IDs
1WYX
3T6G
5O2M
5O2P
5O2Q
3IUC
3LDL
3LDN
3LDO
3LDP
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
6DFM
6DFO
6DO2
6DWS
6ZMD
7N1R
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Focal Adhesion
Non-membrane Spanning Protein Tyrosine Kinase Activity
Phosphotyrosine Residue Binding
Regulation Of Cell Adhesion
Cell Migration
Ephrin Receptor Binding
Cell Surface Receptor Signaling Pathway
Signal Transduction
Cell Motility
Regulation Of Cell-substrate Adhesion
Ephrin Receptor Signaling Pathway
Anchoring Junction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Signal Complex Assembly
Regulation Of Immune System Process
Integrin-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Immune System Process
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Protein Tyrosine Kinase Activity
Fc Receptor Mediated Stimulatory Signaling Pathway
Plasma Membrane
Immune Response-activating Signaling Pathway
Regulation Of Cell Motility
Antigen Receptor-mediated Signaling Pathway
SH3 Domain Binding
Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Regulation Of Locomotion
Regulation Of Intracellular Signal Transduction
Immune Response-regulating Signaling Pathway
Regulation Of Cell Migration
Fc Receptor Signaling Pathway
Activation Of Immune Response
Regulation Of Cell-matrix Adhesion
Intracellular Signal Transduction
Cytosol
Regulation Of Cytoskeleton Organization
Cytoplasm
Regulation Of Signal Transduction
Cell Adhesion
Cell-cell Junction
Regulation Of Cell Junction Assembly
Plasma Membrane Bounded Cell Projection Organization
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Cell Adhesion
Macromolecule Catabolic Process
Regulation Of Protein Localization
Endoplasmic Reticulum
Protein Metabolic Process
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Catabolic Process
Catabolic Process
Protein-folding Chaperone Binding
Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Autophagy
Negative Regulation Of Establishment Of Protein Localization
Adenyl-nucleotide Exchange Factor Activity
Cotranslational Protein Targeting To Membrane
Molecular Sequestering Activity
Proteolysis
Protein Modification Process
Negative Regulation Of Signaling
Regulation Of Protein Metabolic Process
Negative Regulation Of Metabolic Process
Melatonin Receptor Activity
Regulation Of Metabolic Process
Negative Regulation Of Transport
Response To Stress
Regulation Of Protein Transport
Regulation Of Apoptotic Process
Cellular Response To Stress
Regulation Of Signal Transduction
Signal Transduction
Immunoglobulin Binding
Cupric Ion Binding
Negative Regulation Of Protein Transport
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Leukocyte Activation
Scaffold Protein Binding
Regulation Of Type I Interferon Production
Regulation Of Proteolysis
Protein Folding
Positive Regulation Of Transcription By RNA Polymerase I
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Cholesterol Storage
Negative Regulation Of T Cell Activation
Ubiquitin-like Protein Conjugating Enzyme Binding
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?