BCAR1 and INPPL1

Number of citations of the paper that reports this interaction (PMID 11158326)
19

Data Source:
HPRD (in vitro, in vivo)

		BCAR1	INPPL1
Gene Name		breast cancer anti-estrogen resistance 1	inositol polyphosphate phosphatase-like 1
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Lamellipodium Filopodium
	Molecular Function	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding	Actin Binding Protein Binding Hydrolase Activity SH3 Domain Binding SH2 Domain Binding
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis	Endochondral Ossification Immune System Process Glucose Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Proliferation Post-embryonic Development Negative Regulation Of Gene Expression Response To Insulin Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation Ruffle Assembly
Pathways		Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway	Synthesis of PIPs at the plasma membrane Signaling by Interleukins Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Metabolism of lipids and lipoproteins Interleukin receptor SHC signaling Cytokine Signaling in Immune system Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling Inositol phosphate metabolism PI Metabolism
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ	14 interactors: ABL1 BCAR1 CBL CD4 CSF1R EGFR FCGR2B FLNC HID1 MET SHC1 SORBS1 SORBS3 SRC
Entrez ID		9564	3636
HPRD ID		04248	02900
Ensembl ID		ENSG00000050820	ENSG00000165458
Uniprot IDs		B2RBL9 B3KWE2 F5H855 P56945	O15357
PDB IDs		1WYX 3T6G	2K4P 2KSO 3NR8 4A9C
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Transport Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Regulation Of Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Immune Response Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Actin Filament Organization Actin Cytoskeleton Organization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Signaling Regulation Of Cell Motility Positive Regulation Of Cell Migration Actin Filament-based Process Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Locomotion Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement Cell Proliferation Platelet-derived Growth Factor Receptor Signaling Pathway Response To Organic Substance Regulation Of Cellular Amino Acid Metabolic Process
Tagcloud ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Difference) ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Intersection) ?