BCAR1 and PPAP2B

Number of citations of the paper that reports this interaction (PMID 16099422)
9

Data Source:
HPRD (in vitro)

		BCAR1	PPAP2B
Gene Name		breast cancer anti-estrogen resistance 1	phosphatidic acid phosphatase type 2B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium	Golgi Apparatus Plasma Membrane Adherens Junction Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding	Phosphoprotein Phosphatase Activity Integrin Binding Protein Binding Phosphatidate Phosphatase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis	Blood Vessel Development Gastrulation With Mouth Forming Second Negative Regulation Of Protein Phosphorylation Lipid Metabolic Process Phospholipid Metabolic Process Sphingolipid Metabolic Process Germ Cell Migration Dephosphorylation Regulation Of Wnt Signaling Pathway Sphingolipid Biosynthetic Process Homotypic Cell-cell Adhesion Small Molecule Metabolic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Endothelial Cell Migration Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cell-cell Adhesion Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Wound Healing Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Bergmann Glial Cell Differentiation Regulation Of Sphingolipid Mediated Signaling Pathway
Pathways		Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway	Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)	Airflow obstruction ( 22837378) Coronary heart disease ( 21846871 21378988 21378990)
Protein-Protein Interactions		52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ	3 interactors: APP BCAR1 SHC1
Entrez ID		9564	8613
HPRD ID		04248	06179
Ensembl ID		ENSG00000050820	ENSG00000162407
Uniprot IDs		B2RBL9 B3KWE2 F5H855 P56945	O14495
PDB IDs		1WYX 3T6G
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling	Platelet Activation Regulation Of Epidermal Growth Factor-activated Receptor Activity Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Regulation Of Growth Regulation Of Protein Tyrosine Kinase Activity Cell Activation Response To Wounding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Receptor Activity Insulin Receptor Signaling Pathway Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Locomotion Regulation Of Peptidyl-tyrosine Phosphorylation Synaptic Growth At Neuromuscular Junction Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Movement Of Cell Or Subcellular Component Neurotrophin Signaling Pathway Collateral Sprouting In Absence Of Injury Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Axon Choice Point Recognition Regulation Of Cellular Amino Acid Metabolic Process Hepatocyte Growth Factor Receptor Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Response To Peptide Hormone Neuron Remodeling Immune Response-regulating Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Cellular Ketone Metabolic Process Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Chemotaxis Response To Growth Factor Actin Cytoskeleton Organization Actin Filament-based Process Cellular Copper Ion Homeostasis
Tagcloud ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?