BCAR1 and PTPRA

Number of citations of the paper that reports this interaction (PubMedID 15588985)
0

Data Source:
HPRD (in vitro)

		BCAR1	PTPRA
Description		BCAR1 scaffold protein, Cas family member	protein tyrosine phosphatase receptor type A
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Axon Cell Projection Anchoring Junction	Plasma Membrane Focal Adhesion Membrane Receptor Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway	Signal Transduction Integrin-mediated Signaling Pathway Regulation Of Focal Adhesion Assembly
Pathways		Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 33020668) Crohn's disease (time to surgery) ( 23665963) Intracranial aneurysm ( 33199917) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Pancreatic cancer ( 25086665 29422604) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 28552196) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		65 interacting genes: ABL1 AJUBA ANKS1A ARHGAP32 BMX CASP3 CD2AP COPB1 CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EEIG1 EFS ESR1 FAM90A1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NCK2 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PRAM1 PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 USP2 VCL VPS11 YES1 YWHAZ	20 interacting genes: BCAR1 CALM1 FYN GABARAPL2 GAS1 GRB2 HSPB1 HUNK KCNA2 LCOR LINC00839 MBP PRKCD PTGER4 PTPRD PTPRF PTPRM PTPRS RET SRC
Entrez ID		9564	5786
HPRD ID		04248	01476
Ensembl ID		ENSG00000050820	ENSG00000132670
Uniprot IDs		B3KWE2 P56945	A0A1S5UZ22 B7Z2A4 P18433
PDB IDs		1WYX 3T6G 5O2M 5O2P 5O2Q	6UZT
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Focal Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Cell Migration Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Signal Transduction Cell Motility Regulation Of Cell-substrate Adhesion Ephrin Receptor Signaling Pathway Anchoring Junction Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Regulation Of Immune System Process Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Tyrosine Kinase Activity Fc Receptor Mediated Stimulatory Signaling Pathway Plasma Membrane Immune Response-activating Signaling Pathway Regulation Of Cell Motility Antigen Receptor-mediated Signaling Pathway SH3 Domain Binding Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Migration Fc Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell-matrix Adhesion Intracellular Signal Transduction Cytosol Regulation Of Cytoskeleton Organization Cytoplasm Regulation Of Signal Transduction Cell Adhesion Cell-cell Junction Regulation Of Cell Junction Assembly Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion	Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Phosphatase Activity Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Synaptic Membrane Adhesion Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Protein Tyrosine Phosphatase Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity T Cell Costimulation Cell-cell Adhesion Phosphoprotein Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Response To Growth Factor Fc Receptor Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Immune Response-activating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Cellular Response To Hydrogen Peroxide Phospholipase Activator Activity Regulation Of Apoptotic Signaling Pathway Immune Effector Process Regulation Of Immune Response Cell-cell Junction Regulation Of Cell Migration ERBB Signaling Pathway Insulin Receptor Substrate Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Membrane Regulation Of Cell Motility Regulation Of Neuron Projection Development Protein Tyrosine Kinase Activator Activity
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