BCAR1 and PTPRA

Number of citations of the paper that reports this interaction (PMID 15588985)
37

Data Source:
HPRD (in vitro)

		BCAR1	PTPRA
Gene Name		breast cancer anti-estrogen resistance 1	protein tyrosine phosphatase, receptor type, A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis	Protein Phosphorylation Axon Guidance Insulin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation
Pathways		Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway	Axon guidance NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ	12 interactors: BCAR1 CALM1 FYN GABARAPL2 GRB2 KCNA2 PRKCD PTPRD PTPRF PTPRM PTPRS SRC
Entrez ID		9564	5786
HPRD ID		04248	01476
Ensembl ID		ENSG00000050820	ENSG00000132670
Uniprot IDs		B2RBL9 B3KWE2 F5H855 P56945	B7Z2A4 P18433
PDB IDs		1WYX 3T6G
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Platelet Activation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Blood Coagulation Hemostasis Cell Communication Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Growth Factor Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To External Stimulus Cell Adhesion Response To Wounding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Peptidyl-tyrosine Dephosphorylation Signaling Regulation Of Immune Response Nervous System Development Protein Dephosphorylation Phagocytosis T Cell Costimulation Chemotaxis Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Immune Response Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Phosphate-containing Compound Metabolic Process Cellular Response To Peptide Locomotion Response To Platelet-derived Growth Factor Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Cell Surface Receptor Signaling Pathway
Tagcloud ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	aab antigens array auc autoantibodies autoantigens bead biomarkers contain curve igg luminex microarrays nappa nondiscriminating ovarian panel probed programmable ptgfr ranging retested sensitivities sera serous spauc specificity top twelve
Tagcloud (Difference) ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	aab antigens array auc autoantibodies autoantigens bead biomarkers contain curve igg luminex microarrays nappa nondiscriminating ovarian panel probed programmable ptgfr ranging retested sensitivities sera serous spauc specificity top twelve
Tagcloud (Intersection) ?